1215192-68-9
Chemical Structure
KAG-308
- CAS No.: 1215192-68-9
- Formula:C24H30F2N4O3
- Molecular Weight:460.52
IUPAC Name: (3aR,4R,5R,6aS,Z)-2-(4-(1H-tetrazol-5-yl)butylidene)-3,3-difluoro-4-((3R,4R,E)-3-hydroxy-4-(m-tolyl)pent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-ol
InChIKey: KSELABKNBIUMGG-YGBAREPYSA-N
SMILES: O[C@H](C1)[C@H](/C=C/[C@@H](O)[C@@H](C2=CC=CC(C)=C2)C)[C@](C/3(F)F)([H])[C@@]1([H])OC3=C/CCCC4=NN=NN4
Biological Activity: KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a Ki and an EC50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KAG-308 | 98.62% | KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a Ki and an EC50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor. | ||||||||||||||||||||
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Keywords
