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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
138 Results for "
Thioredoxin
" in MedChemExpress (MCE) Product Catalog:
Products (138)
138 Results for "Thioredoxin" in MCE Product Catalog:
45
Áreas de investigación:
Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC50 of 4.2 μM for monkey kidney Vero E6 cells.
20
Target:
Áreas de investigación:
Infection Neurological Disease Inflammation/Immunology Cancer
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
20
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite
Target:
13
Target:
Áreas de investigación:
Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance .
13
13 Cited Publications
Synonyms: IV-2
PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC50 values of 1.9 and 2.9 μM, respectively.
11
11 Cited Publications
TRFS-green is a highly selective off−on fluorescent probe for imaging selenoprotein thioredoxin reductase (TrxR) in living cells. TRFS-green has the maximum absorbance at around 373 nm. After it is activated by TrxR, the maximum absorbance shifts to around 440 nm .
10
10 Cited Publications
Referencia número: HY-N2019
No. CAS: 28097-03-2
6
6 Cited Publications
TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy .
5
5 Cited Publications
Target:
Áreas de investigación:
SRI-37330 is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 can be used for type 2 diabetes research .
5
5 Cited Publications
Target:
Áreas de investigación:
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research .
4
4 Cited Publications
Target:
Áreas de investigación:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease .
2
Target:
Áreas de investigación:
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .
2
2 Cited Publications
Referencia número: HY-D1250
No. CAS: 1859102-62-7
2
2 Cited Publications
Referencia número: HY-D1252
No. CAS: 2966536-18-3
2
2 Cited Publications
Referencia número: HY-P71231
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX1; TDPX2; Prev. PAGA; PAG; Thioredoxin-Dependent Peroxide Reductase 2; Epididymis Secretory Sperm Binding Protein; Thioredoxin-Dependent Peroxiredoxin 1; Thioredoxin-Dependent Peroxiredoxin; Thioredoxin Peroxidase 2; Natural Killer-Enhancing Factor A
2
2
2 Cited Publications
Referencia número: HY-P71147
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX3; Protein MER5 Homolog; Prev. AOP1; Prx-III; AOP-1; HBC189; Thioredoxin-Dependent Peroxide Reductase, Mitochondrial; Epididymis Secretory Sperm Binding Protein; Thioredoxin-Dependent Peroxiredoxin 3; Peroxiredoxin-3; Antioxidant Protein 1; PRO1748; S
2
2 Cited Publications
Referencia número: HY-N6796
No. CAS: 52665-74-4
1
1 Cited Publications
Target:
Áreas de investigación:
SBI-477 is a chemical probe that stimulates insulin signaling by deactivating the transcription factor MondoA. SBI-477 can lead to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes .
1
1 Cited Publications
Referencia número: HY-150228
Pureza: ≥95.0%
MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
