246020-68-8
246020-68-8
Chemical Structure
TRi-1
- CAS No.: 246020-68-8
- Formula:C12H9ClN2O5S
- Molecular Weight:328.73
IUPAC Name: 2-((4-chlorophenyl)sulfonyl)-6-methoxy-3-nitropyridine
InChIKey: PRKWNRUVAZZHPH-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C(OC)N=C1S(=O)(C2=CC=C(Cl)C=C2)=O)[O-]
Biological Activity: TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].
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TRi-1 | 99.69% | TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy. | ||||||||||||||||||||
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References
Keywords
