29 Results for "

Tie2 receptor

" in MedChemExpress (MCE) Product Catalog:
Products (29)

29 Results for "Tie2 receptor" in MCE Product Catalog:

  • Targets Recommended:
Cat. No.: HY-P99036
CAS No.: 1296818-77-3

Target:  

Tie

Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches .
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Cat. No.: HY-P99546
CAS No.: 894356-79-7
Synonyms: 2xCon4C; AMG 386

Target:  

Tie

Research Areas:  

Cardiovascular Disease Cancer

Trebananib (2xCon4C) is an Fc fusion peptibody. Trebananib exerts its effects by blocking the binding of angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) to the TIE2 receptor. Trebananib has anti-angiogenic and anti-tumor activities .
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Cat. No.: HY-P10580
CAS No.: 1359657-45-6
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury .
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Cat. No.: HY-P3369
CAS No.: 2417491-82-6
Synonyms: AXT-107
Gersizangitide (AXT107) is an anti-angiogenic peptide consisting of 20 amino acids, derived from collagen IV. Gersizangitide is an inhibitor of VEGF-A and VEGF-C and an activator of Tie2. Gersizangitide can block VEGF receptor signaling, inhibit vascular leakage, neovascularization and inflammation. Gersizangitide can be used in the research of diseases related to ocular neovascularization and angiogenesis .
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Cat. No.: HY-123450
CAS No.: 1257628-57-1
Purity:  99.60%
Target:  

Bcr-Abl Apoptosis PDGFR

Research Areas:  

Cancer

S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies . S116836 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Cat. No.: HY-P10580A
Vasculotide TFA is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide TFA binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide TFA alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide TFA with antibiotics reduces lung injury .
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Cat. No.: HY-107144
CAS No.: 908265-94-1
Research Areas:  

Cancer

LY2457546 is a potent and orally active multi-targeted anti-angiogenic tyrosine kinases inhibitor. LY2457546 demonstrates potent activity against targets that include VEGFR2, PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. LY2457546 can be used for the research of cancer, such as leukemia .
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Cat. No.: HY-156635
CAS No.: 433224-09-0
Target:  

Tie VEGFR

Research Areas:  

Cardiovascular Disease

TIE-2/VEGFR-2 kinase-IN-3, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 6.9 nM and 3.5 nM, respectively. TIE-2/VEGFR-2 kinase-IN-3 can be used for the research of angiogenesis .
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Cat. No.: HY-156637
CAS No.: 433224-29-4
Target:  

Tie VEGFR

Research Areas:  

Cardiovascular Disease

TIE-2/VEGFR-2 kinase-IN-4, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 5.2 nM and 5.1 nM, respectively. TIE-2/VEGFR-2 kinase-IN-4 can be used for the research of angiogenesis .
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Cat. No.: HY-14243
CAS No.: 856692-39-2
CEP-14083 is a ATP-competitive ALK kinase inhibitor with an IC50 value in enzymatic assays of 2 nM. CEP-14083 also inhibits other kinases, such as insulin receptor (IR), vascular endothelial growth factor receptor 2 (VEGFR2), angiopoietin-1 receptor (TIE2) and dual leucine zipper kinase (DLK). CEP-14083 suppresses CD274 mRNA expression and the NPM/ALK function in the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells. CEP-14083 is promising for research of lymphoma .
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Cat. No.: HY-P73438
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TEK; Tyrosine-Protein Kinase receptor TEK; Prev. VMCM; Endothelial Tyrosine Kinase; VMCM1; Venous Malformations, Multiple Cutaneous And Mucosal; Tie2; Mutant TEK Tyrosine Kinase; Angiopoietin-1 receptor; Soluble Tie2 Variant 2; CD202b; Soluble Tie2 Varian
Species:  
Rat
Source:  
HEK293
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Cat. No.: HY-P73610
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TEK; Tyrosine-Protein Kinase receptor TEK; Prev. VMCM; Endothelial Tyrosine Kinase; VMCM1; Venous Malformations, Multiple Cutaneous And Mucosal; Tie2; Mutant TEK Tyrosine Kinase; Angiopoietin-1 receptor; Soluble Tie2 Variant 2; CD202b; Soluble Tie2 Varian
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P76673
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TEK; Tyrosine-Protein Kinase receptor TEK; Prev. VMCM; Endothelial Tyrosine Kinase; VMCM1; Venous Malformations, Multiple Cutaneous And Mucosal; Tie2; Mutant TEK Tyrosine Kinase; Angiopoietin-1 receptor; Soluble Tie2 Variant 2; CD202b; Soluble Tie2 Varian
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P78568
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TEK; Tyrosine-Protein Kinase receptor TEK; Prev. VMCM; Endothelial Tyrosine Kinase; VMCM1; Venous Malformations, Multiple Cutaneous And Mucosal; Tie2; Mutant TEK Tyrosine Kinase; Angiopoietin-1 receptor; Soluble Tie2 Variant 2; CD202b; Soluble Tie2 Varian
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P73437
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TEK; Tyrosine-Protein Kinase receptor TEK; Prev. VMCM; Endothelial Tyrosine Kinase; VMCM1; Venous Malformations, Multiple Cutaneous And Mucosal; Tie2; Mutant TEK Tyrosine Kinase; Angiopoietin-1 receptor; Soluble Tie2 Variant 2; CD202b; Soluble Tie2 Varian
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P704921
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TEK; Tyrosine-Protein Kinase receptor TEK; Prev. VMCM; Endothelial Tyrosine Kinase; VMCM1; Venous Malformations, Multiple Cutaneous And Mucosal; Tie2; Mutant TEK Tyrosine Kinase; Angiopoietin-1 receptor; Soluble Tie2 Variant 2; CD202b; Soluble Tie2 Varian
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P77232
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TEK; Tyrosine-Protein Kinase receptor TEK; Prev. VMCM; Endothelial Tyrosine Kinase; VMCM1; Venous Malformations, Multiple Cutaneous And Mucosal; Tie2; Mutant TEK Tyrosine Kinase; Angiopoietin-1 receptor; Soluble Tie2 Variant 2; CD202b; Soluble Tie2 Varian
Species:  
Rhesus Macaque
Source:  
HEK293
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Cat. No.: HY-P702705
Purity:  ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: TEK; Tyrosine-Protein Kinase receptor TEK; Prev. VMCM; Endothelial Tyrosine Kinase; VMCM1; Venous Malformations, Multiple Cutaneous And Mucosal; Tie2; Mutant TEK Tyrosine Kinase; Angiopoietin-1 receptor; Soluble Tie2 Variant 2; CD202b; Soluble Tie2 Varian
Species:  
Human
Source:  
Sf9 insect cells
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Cat. No.: HY-P73434
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TEK; Tyrosine-Protein Kinase receptor TEK; Prev. VMCM; Endothelial Tyrosine Kinase; VMCM1; Venous Malformations, Multiple Cutaneous And Mucosal; Tie2; Mutant TEK Tyrosine Kinase; Angiopoietin-1 receptor; Soluble Tie2 Variant 2; CD202b; Soluble Tie2 Varian
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P73436
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TEK; Tyrosine-Protein Kinase receptor TEK; Prev. VMCM; Endothelial Tyrosine Kinase; VMCM1; Venous Malformations, Multiple Cutaneous And Mucosal; Tie2; Mutant TEK Tyrosine Kinase; Angiopoietin-1 receptor; Soluble Tie2 Variant 2; CD202b; Soluble Tie2 Varian
Species:  
Mouse
Source:  
Sf9 insect cells
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