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Urine metabolism

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By Targets:	Antibiotic (1) ATP Synthase (2) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) Carbonic Anhydrase (1) Drug Metabolite (4) Endogenous Metabolite (9) Isotope-Labeled Compounds (1) mTOR (1) Reference Standards (2) SGLT (1) SOD (1)
By Research Areas:	Cancer (4) Infection (1) Metabolic Disease (10) Neurological Disease (8)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Mitochondrial Metabolism

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W012722

4-Methyl-2-oxopentanoic acid 1 Publications Verification α-Ketoisocaproic acid	Endogenous Metabolite Autophagy mTOR SOD	Neurological Disease Metabolic Disease
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .

HY-113126

3-Hydroxyisobutyric acid	Endogenous Metabolite ATP Synthase	Neurological Disease Metabolic Disease
3-Hydroxyisobutyric acid is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis .

HY-128733

Phenyl acetate	Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Phenyl acetate is an endogenous metabolite and a metabolite of 2-phenylethylamine, which can be found in urine. Phenyl acetate regulates the metabolism of glutamine. In addition, Phenyl acetate can be used as a detection index for certain diseases, such as depression .

HY-W561907

IMipenem and cilastatin sodium	Antibiotic Bacterial	Infection
IMipenem and cilastatin sodium is a broad-spectrum Carbapenem Antibiotic combination. Imipenem (HY-B1369A) is a Carbapenem antibiotic. IMipenem demonstrates excellent activity against gram-positive and gram-negative aerobic and anaerobic organisms. Cilastatin (HY-A0166) is a renal Dehydropeptidase inhibitor that inhibits the metabolism of Imipenem by renal brush-border enzymes, thus increasing imipenem concentrations in urine .

HY-128733R

Phenyl acetate (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Phenyl acetate (Standard) is the analytical standard of Phenyl acetate. This product is intended for research and analytical applications. Phenyl acetate is an endogenous metabolite and a metabolite of 2-phenylethylamine, which can be found in urine. Phenyl acetate regulates the metabolism of glutamine. In addition, Phenyl acetate can be used as a detection index for certain diseases, such as depression.

HY-W012168

4-Chloro-3-sulfamoylbenzoic acid	Carbonic Anhydrase	Metabolic Disease
4-Chloro-3-sulfamoylbenzoic acid is a weak inhibitor of human carbonic anhydrase isoforms hCA I, hCA II, hCA IV, and hCA IX, and a synthesis intermediate for carbonic anhydrase inhibitors. 4-Chloro-3-sulfamoylbenzoic acid is the major metabolite of tripamide detected in tissues, urine, and feces of rats and rabbits following Tripamide (HY-106570) administration. 4-Chloro-3-sulfamoylbenzoic acid can be used for the study of carbonic anhydrase inhibition and species differences in drug metabolism .

HY-W002110

Isohomovanillic acid 3-Hydroxy-4-methoxyphenylacetic acid; iso-HVA; Homoisovanillic acid	Drug Metabolite	Neurological Disease
Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is a product of catecholamine metabolism. Isohomovanillic acid can be isolated from urine. Isohomovanillic acid can be used in the research of Parkinson's disease .

HY-113104

Androsterone glucuronide ADT-G	Endogenous Metabolite Drug Metabolite	Metabolic Disease
Androsterone glucuronide (ADT-G) is one of the main metabolites of oral testosterone in humans and can be found in urine. The level of Androsterone glucuronide can reflect the absorption and hepatic metabolism of testosterone .

HY-128733S

Phenyl acetate-d5	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Phenyl acetate-d₅ is the deuterium labeled Phenyl acetate. Phenyl acetate is an endogenous metabolite and a metabolite of 2-phenylethylamine, which can be found in urine. Phenyl acetate regulates the metabolism of glutamine. In addition, Phenyl acetate can be used as a detection index for certain diseases, such as depression .

HY-160542

Clenhexyl hydrochloride	Endogenous Metabolite	Others
Clenhexyl hydrochloride is a urinary metabolite useful for quantitative screening in doping control screening programs .

HY-156558

SeGalNac	Endogenous Metabolite	Metabolic Disease
SeGalNac is a selenium metabolite found in human urine. SeGalNac can be used in the study of selenoglucose metabolism .

HY-W002110R

Isohomovanillic acid (Standard) 3-Hydroxy-4-methoxyphenylacetic acid (Standard); iso-HVA (Standard); Homoisovanillic acid (Standard)	Reference Standards Drug Metabolite	Neurological Disease
Isohomovanillic acid (Standard) is an analytical standard of Isohomovanillic acid (HY-W002110). This product is intended for research and analytical applications. Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is a product of catecholamine metabolism. Isohomovanillic acid can be isolated from urine. Isohomovanillic acid can be used in the research of Parkinson's disease .

HY-N15717

(erythro) 1′,2′-Dihydroxyasarone	Drug Metabolite	Others
(erythro) 1′,2′-Dihydroxyasarone is a metabolite of Beta-asarone (HY-N1501) and can also be isolated from the roots of Acorus tatarinowii. (erythro) 1′,2′-Dihydroxyasarone can form glucuronic acid conjugates in vivo and be excreted in urine. (erythro) 1′,2′-Dihydroxyasarone can serve as a marker for the metabolism and toxic risk assessment of Beta-asarone .

HY-114598

WAY-123783	SGLT	Metabolic Disease
WAY-123783 is a potent, selective and orally active sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor producing activity after metabolism. WAY-123783 can increase the excretion of sugar in urine and at the same time lower the blood sugar level in db/db mice (ED₅₀ = 9.85 mg/kg). WAY-123783 can be used for the research of metabolic disease, such as diabetes .

HY-113126A

3-Hydroxyisobutyric acid sodium	Endogenous Metabolite ATP Synthase	Neurological Disease Metabolic Disease
3-Hydroxyisobutyric acid sodium is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid sodium is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid sodium can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid sodium are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis .

HY-N13079

3-Epicinobufagin	Others	Others
3-Epicinobufagin (compound IX) can be used as an internal standard for the metabolism of Bufalin (HY-N0877), by detecting its content in serum and urine to provide feedback on the corresponding metabolic status .

HY-W438378

4-Hydroxy-3-methoxyphenylglycol piperazine HMPG piperazine	Biochemical Assay Reagents	Others
4-Hydroxy-3-methoxyphenylglycol piperazine (HMPG piperazine) is a salt of HMPG combined with piperazine. HMPG is a metabolite of adrenaline and norepinephrine and is an important marker of catecholamine hormone metabolism in the body. 4-Hydroxy-3-methoxyphenylglycol piperazine is used as a standard in clinical laboratories to accurately measure the HMPG content in urine .

HY-N11738

Aspalathin	Others	Cancer
Aspalathin is a C-glycosyldihydrochalcone flavonoid and antioxidant.Aspalathin functions as an antimutagen.Aspalathin can be absorbed by pig intestine as a C-glycoside, and can also be cleaved into its aglycone and sugar moiety.Aspalathin is found in Aspalathus linearis (rooibos) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012722

4-Methyl-2-oxopentanoic acid 1 Publications Verification α-Ketoisocaproic acid	Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Source Classification	Endogenous Metabolite Autophagy mTOR SOD
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .

HY-113126

3-Hydroxyisobutyric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite ATP Synthase
3-Hydroxyisobutyric acid is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis .

HY-128733

Phenyl acetate	Natural Products Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Phenyl acetate is an endogenous metabolite and a metabolite of 2-phenylethylamine, which can be found in urine. Phenyl acetate regulates the metabolism of glutamine. In addition, Phenyl acetate can be used as a detection index for certain diseases, such as depression .

HY-128733R

Phenyl acetate (Standard)	Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Phenyl acetate (Standard) is the analytical standard of Phenyl acetate. This product is intended for research and analytical applications. Phenyl acetate is an endogenous metabolite and a metabolite of 2-phenylethylamine, which can be found in urine. Phenyl acetate regulates the metabolism of glutamine. In addition, Phenyl acetate can be used as a detection index for certain diseases, such as depression.

HY-W002110

Isohomovanillic acid 3-Hydroxy-4-methoxyphenylacetic acid; iso-HVA; Homoisovanillic acid	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Source Classification Cancer	Drug Metabolite
Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is a product of catecholamine metabolism. Isohomovanillic acid can be isolated from urine. Isohomovanillic acid can be used in the research of Parkinson's disease .

HY-156558

SeGalNac	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
SeGalNac is a selenium metabolite found in human urine. SeGalNac can be used in the study of selenoglucose metabolism .

HY-W002110R

Isohomovanillic acid (Standard) 3-Hydroxy-4-methoxyphenylacetic acid (Standard); iso-HVA (Standard); Homoisovanillic acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Reference Standards Drug Metabolite
Isohomovanillic acid (Standard) is an analytical standard of Isohomovanillic acid (HY-W002110). This product is intended for research and analytical applications. Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is a product of catecholamine metabolism. Isohomovanillic acid can be isolated from urine. Isohomovanillic acid can be used in the research of Parkinson's disease .

HY-N15717

(erythro) 1′,2′-Dihydroxyasarone	Natural Products Araceae Acorus gramineus Soland. Plants Source Classification	Drug Metabolite
(erythro) 1′,2′-Dihydroxyasarone is a metabolite of Beta-asarone (HY-N1501) and can also be isolated from the roots of Acorus tatarinowii. (erythro) 1′,2′-Dihydroxyasarone can form glucuronic acid conjugates in vivo and be excreted in urine. (erythro) 1′,2′-Dihydroxyasarone can serve as a marker for the metabolism and toxic risk assessment of Beta-asarone .

HY-N13079

3-Epicinobufagin	Animals Steroids Source Classification	Others
3-Epicinobufagin (compound IX) can be used as an internal standard for the metabolism of Bufalin (HY-N0877), by detecting its content in serum and urine to provide feedback on the corresponding metabolic status .

HY-W438378

4-Hydroxy-3-methoxyphenylglycol piperazine HMPG piperazine	Monophenols Phenols Endogenous metabolite Source Classification	Biochemical Assay Reagents
4-Hydroxy-3-methoxyphenylglycol piperazine (HMPG piperazine) is a salt of HMPG combined with piperazine. HMPG is a metabolite of adrenaline and norepinephrine and is an important marker of catecholamine hormone metabolism in the body. 4-Hydroxy-3-methoxyphenylglycol piperazine is used as a standard in clinical laboratories to accurately measure the HMPG content in urine .

HY-N11738

Aspalathin	Structural Classification Leguminosae Phenols Polyphenols Plants Source Classification Aspalathus linearis (Burm.f.) R.Dahlgren	Others
Aspalathin is a C-glycosyldihydrochalcone flavonoid and antioxidant.Aspalathin functions as an antimutagen.Aspalathin can be absorbed by pig intestine as a C-glycoside, and can also be cleaved into its aglycone and sugar moiety.Aspalathin is found in Aspalathus linearis (rooibos) .

Cat. No.	Product Name	Chemical Structure

HY-128733S

Phenyl acetate-d5
Phenyl acetate-d₅ is the deuterium labeled Phenyl acetate. Phenyl acetate is an endogenous metabolite and a metabolite of 2-phenylethylamine, which can be found in urine. Phenyl acetate regulates the metabolism of glutamine. In addition, Phenyl acetate can be used as a detection index for certain diseases, such as depression .

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Urine metabolism

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products