Search Result

Results for "

Wnt-β-catenin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (7) AMPK (4) Amyloid-β (4) Antibiotic (8) Apoptosis (37) Arf Family GTPase (1) Arginase (2) Atg8/LC3 (2) Autophagy (16) Bacterial (12) Bcl-2 Family (3) Beclin1 (1) Beta-secretase (1) Biochemical Assay Reagents (3) c-Myc (7) Cadherin (1) Carbonic Anhydrase (1) Carboxylesterase (CES) (1) Casein Kinase (5) Caspase (1) CDK (16) Cholinesterase (ChE) (1) Claudin (1) Collagen (1) COX (2) CXCR (1) Cyclin G-associated Kinase (GAK) (1) DNA/RNA Synthesis (2) Drug Derivative (1) DYRK (1) E1/E2/E3 Enzyme (1) EGFR (2) Endogenous Metabolite (5) Environmental Pollutants (1) ERK (11) Estrogen Receptor/ERR (1) Ferroptosis (2) Fungal (3) Glucocorticoid Receptor (5) Glutathione Peroxidase (2) GSK-3 (18) HDAC (2) Heme Oxygenase (HO) (1) Histone Acetyltransferase (1) Histone Demethylase (1) HSP (1) IKK (2) Interleukin Related (5) Isotope-Labeled Compounds (4) JNK (10) Keap1-Nrf2 (1) LXR (1) MDM-2/p53 (3) Microtubule/Tubulin (4) Mitophagy (2) MMP (2) mTOR (5) Natriuretic Peptide Receptor (NPR) (1) Neurokinin Receptor (1) Neuropeptide Y Receptor (1) NF-κB (9) NO Synthase (2) NOD-like Receptor (NLR) (3) Notch (1) Nuclear Factor of activated T Cells (NFAT) (1) Organoid (9) P-glycoprotein (2) p38 MAPK (10) p62 (2) Parasite (7) PARP (9) Phosphodiesterase (PDE) (6) PI3K (2) Porcupine (2) Potassium Channel (3) PPAR (2) Prostaglandin Receptor (1) PROTACs (3) Protease Activated Receptor (PAR) (1) Pyroptosis (3) Pyruvate Carboxylase (PC) (1) RANKL/RANK (1) RAR/RXR (1) Ras (1) Reactive Oxygen Species (ROS) (9) Reference Standards (31) RUNX (2) sFRP-1 (1) STAT (2) Survivin (2) Tau Protein (1) TGF-beta/Smad (10) TGF-β Receptor (1) TNF Receptor (2) Topoisomerase (1) Transthyretin (TTR) (1) VEGFR (3) Wee1 (2) Wnt (184) α-synuclein (1) β-catenin (131)
By Research Areas:	Cancer (131) Cardiovascular Disease (10) Endocrinology (4) Infection (13) Inflammation/Immunology (47) Metabolic Disease (40) Neurological Disease (34)

By Targets:

Akt (7)

AMPK (4)

Amyloid-β (4)

Antibiotic (8)

Apoptosis (37)

Arf Family GTPase (1)

Arginase (2)

Atg8/LC3 (2)

Autophagy (16)

Bacterial (12)

Bcl-2 Family (3)

Beclin1 (1)

Beta-secretase (1)

Biochemical Assay Reagents (3)

c-Myc (7)

Cadherin (1)

Carbonic Anhydrase (1)

Carboxylesterase (CES) (1)

Casein Kinase (5)

Caspase (1)

CDK (16)

Cholinesterase (ChE) (1)

Claudin (1)

Collagen (1)

COX (2)

CXCR (1)

Cyclin G-associated Kinase (GAK) (1)

DNA/RNA Synthesis (2)

Drug Derivative (1)

DYRK (1)

E1/E2/E3 Enzyme (1)

EGFR (2)

Endogenous Metabolite (5)

Environmental Pollutants (1)

ERK (11)

Estrogen Receptor/ERR (1)

Ferroptosis (2)

Fungal (3)

Glucocorticoid Receptor (5)

Glutathione Peroxidase (2)

GSK-3 (18)

HDAC (2)

Heme Oxygenase (HO) (1)

Histone Acetyltransferase (1)

Histone Demethylase (1)

HSP (1)

IKK (2)

Interleukin Related (5)

Isotope-Labeled Compounds (4)

JNK (10)

Keap1-Nrf2 (1)

LXR (1)

MDM-2/p53 (3)

Microtubule/Tubulin (4)

Mitophagy (2)

MMP (2)

mTOR (5)

Natriuretic Peptide Receptor (NPR) (1)

Neurokinin Receptor (1)

Neuropeptide Y Receptor (1)

NF-κB (9)

NO Synthase (2)

NOD-like Receptor (NLR) (3)

Notch (1)

Nuclear Factor of activated T Cells (NFAT) (1)

Organoid (9)

P-glycoprotein (2)

p38 MAPK (10)

p62 (2)

Parasite (7)

PARP (9)

Phosphodiesterase (PDE) (6)

PI3K (2)

Porcupine (2)

Potassium Channel (3)

PPAR (2)

Prostaglandin Receptor (1)

PROTACs (3)

Protease Activated Receptor (PAR) (1)

Pyroptosis (3)

Pyruvate Carboxylase (PC) (1)

RANKL/RANK (1)

RAR/RXR (1)

Ras (1)

Reactive Oxygen Species (ROS) (9)

Reference Standards (31)

RUNX (2)

sFRP-1 (1)

STAT (2)

Survivin (2)

Tau Protein (1)

TGF-beta/Smad (10)

TGF-β Receptor (1)

TNF Receptor (2)

Topoisomerase (1)

Transthyretin (TTR) (1)

VEGFR (3)

Wee1 (2)

Wnt (184)

α-synuclein (1)

β-catenin (131)

By Research Areas:

Cancer (131)

Cardiovascular Disease (10)

Endocrinology (4)

Infection (13)

Inflammation/Immunology (47)

Metabolic Disease (40)

Neurological Disease (34)

195

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12238

IWR-1 60+ Cited Publications endo-IWR 1; IWR-1-endo	Organoid Wnt	Inflammation/Immunology Cancer
IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting *Wnt/β-catenin* (IC₅₀ = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .

HY-N0020

Echinacoside 15+ Cited Publications	Wnt Reactive Oxygen Species (ROS)	Neurological Disease
Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity .

HY-120697

MSAB 45+ Cited Publications	Wnt β-catenin	Cancer
MSAB is a potent and selective inhibitor of *Wnt/β-catenin* signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells .

HY-15597

Salinomycin 45+ Cited Publications Procoxacin	Bacterial Wnt β-catenin Mitophagy Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of *Wnt/β-catenin* signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells .

HY-17439

Salinomycin sodium salt 45+ Cited Publications Salinomycin sodium; Sodium salinomycin	Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of *Wnt/β-catenin* signaling. Salinomycin sodium salt acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt shows selective activity against human cancer stem cells .

HY-101085

SKL2001 60+ Cited Publications	Wnt β-catenin	Cancer
SKL2001 is an agonist of the *Wnt/β-catenin* pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction .

HY-10590

TWS119 30+ Cited Publications	Wnt GSK-3 Autophagy	Neurological Disease Cancer
TWS119 is an inhibitor of GSK-3β, with an IC₅₀ of 30 nM, and activates the wnt/β-catenin pathway.

HY-N1499

Nystose	Wnt β-catenin TGF-beta/Smad Bacterial	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Nystose is a tetrasaccharide with two fructose molecules linked via beta (1→2) bonds to the fructosyl moiety of sucrose. Nystose exhibits prebiotic, immunomodulatory, and metabolism regulating activities. Nystose promotes the bone mineralization by activating the *Wnt/β-catenin* signaling pathway .

HY-11035

WAY-262611 10+ Cited Publications	β-catenin Wnt	Cancer
WAY-262611 is a *Wnt/β-Catenin* agonist that increases bone formation rate with an EC₅₀ of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor .

HY-N0101

Neohesperidin 5+ Cited Publications Hesperetin 7-O-neohesperidoside	β-catenin Wnt	Inflammation/Immunology
Neohesperidin is a flavonoid compound abundant in citrus plants with antioxidant and anti-inflammatory effects. Neohesperidin can upregulate the *Wnt/β-catenin* signaling pathway, enhance the nuclear translocation of β-catenin and the differentiation of bone marrow stromal cells .

HY-N1411

Platycodin D 5+ Cited Publications	AMPK Wnt	Metabolic Disease
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. *WNT/β-catenin* pathway mediates the anti-adipogenic effect of platycodin D .

HY-100711

Prodigiosin 3 Publications Verification Prodigiosine; NSC47147	Bacterial Apoptosis Wnt Fungal Parasite	Infection Inflammation/Immunology Cancer
Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the *Wnt/β-catenin* pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-151520

Wnt/β-catenin agonist 4	Wnt	Cancer
Wnt/β-catenin agonist 4 (Derivative 83) is an agonist of Wnt that activates *Wnt/β-catenin* signal transmission .

HY-75342

Methyl vanillate 2 Publications Verification	Wnt Reactive Oxygen Species (ROS) Endogenous Metabolite	Inflammation/Immunology Cancer
Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a *Wnt/β-catenin* pathway activator . A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

HY-15721

FH535 15+ Cited Publications	PPAR Wnt β-catenin	Cancer
FH535 is an inhibitor of *Wnt/β-catenin* and PPAR with anti-tumor activities .

HY-101130

PNU-74654 10+ Cited Publications	Wnt β-catenin Apoptosis	Cancer
PNU-74654 is an inhibitor of *Wnt/β-catenin* pathway with an IC₅₀ of 129.8 μM in NCI-H295 cell.

HY-16910

WIKI4 4 Publications Verification	PARP β-catenin Wnt	Cancer
WIKI4 is a potent tankyrase inhibitor with an IC₅₀ of 26 nM for TNKS2. WIKI4 potently inhibits *Wnt/β-catenin* signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on *Wnt/β-catenin* signaling by inhibiting the enzymatic activity of TNKS2 . WIKI4 is cytotoxic to SCLC cells with an IC₅₀ value of 0.02 μM .

HY-N0432

Astragaloside I Astrasieversianin IV; Cyclosieversioside B	Wnt β-catenin	Metabolic Disease
Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through activating the *Wnt/β-catenin* signaling pathway .

HY-N0279

Cardamonin 15+ Cited Publications Cardamomin; Alpinetin chalcone	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, *Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-145267

OM-153	PARP Wnt	Cancer
OM-153 is a potent and orally active tankyrase inhibitor with IC₅₀s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based *Wnt/β-catenin* signaling reporter activity with an IC₅₀ value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM .

HY-141891

M435-1279	Wnt E1/E2/E3 Enzyme	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the *Wnt/β-catenin* signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1 .

HY-119711

NNGH	MMP	Cancer
NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression .

HY-P5819

xStAx-VHLL 3 Publications Verification	Wnt PROTACs β-catenin	Cancer
xStAx-VHLL is a *β-catenin* PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL inhibits the Wnt/β-catenin** signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-12762

QS11 2 Publications Verification	β-catenin Wnt Arf Family GTPase	Cancer
QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC₅₀ of 1.5 μM. QS11 activates *Wnt/β-catenin* signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells .

HY-129566

Withanolide B	ERK Wnt β-catenin RUNX	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-172920

Wnt/β-catenin-IN-6	Wnt β-catenin EGFR ERK COX Akt GSK-3 c-Myc Apoptosis Interleukin Related JNK	Inflammation/Immunology Cancer
Wnt/β-catenin-IN-6 is an orally active *Wnt/β-catenin* pathway inhibitor. Wnt/β-catenin-IN-6 blocks the *AKT/GSK-3β/β-catenin* signaling pathway, leading to reduced expression of Wnt target genes (c-Myc, c-Jun). Wnt/β-catenin-IN-6 reduces COX2 expression and IL-8 levels, highlighting its dual anti-inflammatory and antitumor effects. Wnt/β-catenin-IN-6 can induce apoptosis. Wnt/β-catenin-IN-6 serves as a tool for non-small cell lung cancer (NSCLC) research .

HY-148055

Wnt/β-catenin agonist 3	Wnt β-catenin	Cardiovascular Disease
Wnt/β-catenin agonist 3 (compound 98) is a *Wnt/β-catenin* signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis .

HY-101090

KYA1797K 15+ Cited Publications	Wnt β-catenin	Cancer
KYA1797K is a potent and selective *Wnt/β-catenin* inhibitor with an IC₅₀ of 0.75 µM.

HY-141873

Wnt/β-catenin agonist 2 1 Publications Verification	Wnt β-catenin	Others
Wnt/β-catenin agonist 2 is a potent Wnt agonist. Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and can be used in the research of diseases related to the signal transduction . (From patent WO2007078113A1, compound 39)

HY-114321

Wnt/β-catenin agonist 1 5+ Cited Publications	Wnt	Cancer
Wnt/β-catenin agonist 1 (compound 3f) is a *Wnt/β-catenin* signalling pathway agonist, with an EC₅₀ of 0.27 μM .

HY-164478

G-631	PARP Wnt β-catenin	Cancer
G-631 is an orally active tankyrase(TNKS1/TNKS2) inhibitor. G-631 stabilizes AXIN and inhibits the *Wnt/β-catenin* signaling pathway. G-631 can be used in studies related to cancers such as colorectal cancer .

HY-102028

KY1220 3 Publications Verification	Wnt β-catenin	Cancer
KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the *Wnt/β-catenin* pathway, with an IC₅₀ of 2.1 μM in HEK293 reporter cells .

HY-18959

CWP232228 5+ Cited Publications	β-catenin Wnt	Cancer
CWP232228, a highly potent selective *Wnt/β-catenin* signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) .

HY-P10392AF

fStAx-35R TFA	Wnt β-catenin	Cancer
fStAx-35R TFA is the hydrocarbon-stapled peptide. fStAx-35R TFA inhibits *Wnt/β-catenin* signaling pathway by disrupting the β-catenin-TCF interaction. fStAx-35R TFA can be used in cancer research .

HY-121993

Combretastatin A-1 1 Publications Verification	Wnt Microtubule/Tubulin	Cancer
Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the *Wnt/β-catenin* pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects .

HY-160709

Wnt/β-catenin-IN-2	Wnt β-catenin	Cancer
Wnt/β-catenin-IN-2 (Compound 3235-0367) is a *Wnt/β-catenin* signaling pathway inhibitor, with IC₅₀ and K_D values of 7.1 and 2.5 μM, respectively. Wnt/β-catenin-IN-2 can be used for the research of cancer .

HY-N2156

Paeonolide	ERK TGF-beta/Smad Wnt β-catenin JNK p38 MAPK	Metabolic Disease Inflammation/Immunology
Paeonolide, found in Paeonia suffruticosa, is an ERK1/2 activator. Paeonolide promotes early and late osteoblast differentiation, stimulates pre-osteoblast transmigration, and activates the BMP-Smad1/5/8, *Wnt-β-catenin, JNK* and p38 pathways. Paeonolide can be used for the research of osteoporosis, periodontitis .

HY-P1454

Fz7-21 3 Publications Verification Ac-LPSDDLEFWCHVMY-NH2	Wnt	Cancer
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC₅₀ values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids .

HY-N2785

Desmethylicaritin	Wnt	Metabolic Disease
Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway .

HY-124156A

KY-02327 acetate	Wnt	Metabolic Disease
KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .

HY-P4858

C-Peptide 1 (rat)	GSK-3 Wnt	Cancer
C-Peptide 1 (rat), a peptide, is aβ-catenin/GSK-3β activator. C-Peptide 1 (rat) can regulate the Wnt/β-catenin signaling pathway. C-Peptide 1 (rat) can be used for the research of cancer .

HY-112799

DK419	Wnt β-catenin c-Myc CDK Survivin	Cancer
DK419 is a potent and orally active *Wnt/β-catenin* signaling inhibitor, with an IC₅₀ of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK .

HY-151463

CDK8-IN-11	Wnt CDK β-catenin	Cancer
CDK8-IN-11 is a potent and selective CDK8 inhibitor with an IC₅₀ value of 46 nM. CDK8-IN-11 inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 can be used in the research of colon cancer .

HY-N3149A

2-Hydroxycinnamaldehyde	Wnt β-catenin STAT Apoptosis	Inflammation/Immunology
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits *Wnt/β-catenin, STAT3* signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities .

HY-P5819A

xStAx-VHLL TFA 3 Publications Verification	PROTACs β-catenin Wnt	Cancer
xStAx-VHLL TFA is a *β-catenin* PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL TFA inhibits the Wnt/β-catenin** signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-115539

Windorphen	Wnt β-catenin Histone Acetyltransferase	Cancer
Windorphen is a *Wnt/β-catenin* signal inhibitor that specifically targets the function of the c-terminal transactivation domain of *β-catenin-1* but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP .

HY-173482

*TFAP4/Wnt/β-catenin-IN-1*	Wnt β-catenin	Cancer
TFAP4/Wnt/β-catenin-IN-1 (Compound A61) is an orally active *TFAP4/Wnt/β-catenin* inhibitor. TFAP4/Wnt/β-catenin-IN-1 has significant anticancer activity against a variety of cancer cells (such as gastric cancer, lung cancer, breast cancer, etc.), and has the strongest anticancer activity against MGC-803 gastric cancer cells (IC₅₀: 3.92 μM). TFAP4/Wnt/β-catenin-IN-1 induces apoptosis and cell cycle arrest (S phase) in cancer cells by inhibiting the TFAP4/Wnt/β-catenin signaling pathway. TFAP4/Wnt/β-catenin-IN-1 can be used in the study of gastric cancer .

HY-137454

Teplinovivint 2 Publications Verification	Wnt β-catenin	Inflammation/Immunology
Teplinovivint is a potent *wnt/β-catenin* signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research .

HY-W010995

2,5-Dimethylcelecoxib	Wnt Survivin β-catenin	Cancer
2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the *Wnt/β-catenin* signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin .

HY-P11112

PTD-DBM	β-catenin Wnt Collagen	Inflammation/Immunology
PTD-DBM is a CXXC5-Dvl protein-protein interaction inhibitor and also a *Wnt/β-catenin* pathway activator. PTD-DBM interferes with the Dvl-binding function of CXXC5, disrupts the negative feedback regulation of the Wnt/β-catenin pathway, induces β-catenin expression and nuclear translocation, and increases the production of type I collagen, α-smooth muscle actin and endothelin-1. PTD-DBM is applicable to studies related to androgenetic alopecia and skin wound healing .

Cat. No.	Product Name

HY-L038

Differentiation Inducing Compound Library

2,405 compounds

Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.

MCE Differentiation Inducing Compound Library contains a unique collection of 2,405 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

HY-L103

Anti-Colorectal Cancer Compound Library

2,491 compounds

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, arises as adenocarcinoma from glandular epithelial cells of the large intestine comprised of the colon and rectum. The majority of cases of CRC are sporadic and result from risk factors, such as a sedentary lifestyle, obesity, processed diets, alcohol consumption and smoking. CRC is also a common preventable cancer.

Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, it is necessary to analyze the signaling pathways involved in the occurrence and development of colorectal cancer to study the progression and drug treatment of colorectal cancer. Among them, Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF and other target genes and signaling pathways are the focus of research. MCE offers a unique collection of 2,491 compounds with identified and potential anti-colorectal cancer activity. MCE anti-colorectal cancer compound library is a useful tool for anti-colorectal cancer drugs screening and other related research.

Cat. No.	Product Name	Type

HY-101085G

SKL2001 (GMP)	Fluorescent Dyes
SKL2001 (GMP) is SKL2001 (HY-101085) produced by using GMP guidelines. SKL2001 is an agonist of the *Wnt/β-catenin* pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction .

HY-12238G

IWR-1

endo-IWR 1; IWR-1-endo

Fluorescent Dyes

IWR-1 (IWR-1-endo) (GMP) is the IWR-1 (HY-12238) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC₅₀ = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .

Cat. No.	Product Name	Type

HY-Y1325I

Sodium acetate trihydrate, 99.5%

Biochemical Assay Reagents

Sodium acetate trihydrate, 99.5% is a short-chain fatty acid salt with multiple biological activities. Sodium acetate trihydrate, 99.5% serves as a direct precursor of acetyl-CoA, and it extensively affects gene expression by promoting histone acetylation. Sodium acetate trihydrate, 99.5% can activate the p38 MAPK pathway to induce cancer cell apoptosis. Sodium acetate trihydrate, 99.5% can activate the Wnt/β-catenin signaling pathway to stimulate the proliferation and migration of cecal epithelial cells, thereby improving intestinal health. Sodium acetate trihydrate, 99.5% alleviates lead accumulation and oxidative damage by upregulating the testosterone-dependent eNOS/NO/cGMP signaling pathway, as well as activating the Nrf2/HO-1 pathway and its downstream antioxidant enzymes .

HY-101085G

SKL2001 (GMP)	Biochemical Assay Reagents
SKL2001 (GMP) is SKL2001 (HY-101085) produced by using GMP guidelines. SKL2001 is an agonist of the *Wnt/β-catenin* pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction .

HY-12238G

IWR-1

endo-IWR 1; IWR-1-endo

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P5819

xStAx-VHLL 3 Publications Verification	Wnt PROTACs β-catenin	Cancer
xStAx-VHLL is a *β-catenin* PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL inhibits the Wnt/β-catenin** signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P10392AF

fStAx-35R TFA	Wnt β-catenin	Cancer
fStAx-35R TFA is the hydrocarbon-stapled peptide. fStAx-35R TFA inhibits *Wnt/β-catenin* signaling pathway by disrupting the β-catenin-TCF interaction. fStAx-35R TFA can be used in cancer research .

HY-P1454

Fz7-21 3 Publications Verification Ac-LPSDDLEFWCHVMY-NH2	Wnt	Cancer
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC₅₀ values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids .

HY-P4858

C-Peptide 1 (rat)	GSK-3 Wnt	Cancer
C-Peptide 1 (rat), a peptide, is aβ-catenin/GSK-3β activator. C-Peptide 1 (rat) can regulate the Wnt/β-catenin signaling pathway. C-Peptide 1 (rat) can be used for the research of cancer .

HY-P5819A

xStAx-VHLL TFA 3 Publications Verification	PROTACs β-catenin Wnt	Cancer
xStAx-VHLL TFA is a *β-catenin* PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL TFA inhibits the Wnt/β-catenin** signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P11112

PTD-DBM	β-catenin Wnt Collagen	Inflammation/Immunology
PTD-DBM is a CXXC5-Dvl protein-protein interaction inhibitor and also a *Wnt/β-catenin* pathway activator. PTD-DBM interferes with the Dvl-binding function of CXXC5, disrupts the negative feedback regulation of the Wnt/β-catenin pathway, induces β-catenin expression and nuclear translocation, and increases the production of type I collagen, α-smooth muscle actin and endothelin-1. PTD-DBM is applicable to studies related to androgenetic alopecia and skin wound healing .

HY-P1454A

Fz7-21 TFA 3 Publications Verification Ac-LPSDDLEFWCHVMY-NH2 TFA	Wnt	Cancer
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC₅₀ values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids .

HY-P6441

KP-6	β-catenin Wnt	Inflammation/Immunology
KP-6, a polypeptide, is a *Wnt/β-catenin* signal inhibitor. KP-6 inhibits TGF-β and blocks rush fibrosis signal path crucial in vivo. KP-6 suppresses Renal tissues damage and renal fibrosis, and reverse the course of disease of chronic kidney disease (CKD) .

HY-P10652

hsBCL9CT-24	Wnt β-catenin	Cancer
hsBCL9CT-24 is a *Wnt/β-catenin* (b-cat) pathway inhibitor with potent anti-tumor effect. hsBCL9CT-24 reactivates anti-cancer immune response suppressed by the oncogenic Wnt pathway and can be utilized for cancer research .

HY-P11597

Getacatetide CY-101	Wnt β-catenin	Cancer
Getacatetide (CY-101) is a peptide-based *Wnt/β-catenin* inhibitor, which can be used for the study of solid tumors .

HY-P11867

UM206_L	Wnt β-catenin	Others
UM206_L is a linear Wnt fragment peptide derived from conserved Wnt3a/Wnt5a sequences, inactive in soluble form but capable of activating canonical *Wnt/β-catenin* signaling when conjugated to magnetic nanoparticles and exposed to a high-gradient, time-varying magnetic field or immobilized on glass surfaces .

HY-P11867A

UM206_C	Wnt β-catenin	Others
UM206_C is a circular Wnt fragment peptide derived from conserved Wnt3a/Wnt5a sequences, inactive in soluble form but capable of activating canonical *Wnt/β-catenin* signaling when conjugated to magnetic nanoparticles and exposed to a high-gradient, time-varying magnetic field or immobilized on glass surfaces .

Cat. No.	Product Name

HY-K6303

Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit

MCE Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit is based on the classical GiWi system. By precisely modulating the Wnt/β-catenin signaling pathway in a temporally controlled manner (sequential activation and inhibition), the kit enables highly efficient directed differentiation of human pluripotent stem cells into cardiomyocytes. It is suitable for cardiac disease modeling, drug cardiotoxicity assessment, and mechanistic studies.

HY-K6301

Human iPSC/ESC Cortical Brain Organoid Induction Differentiation Kit

MCE Human iPSC/ESC Cortical Brain Organoid Induction Differentiation Kit is a standardized culture system specifically designed to recapitulate the developmental processes and functional features of the human cerebral cortex through forebrain ventralization-based signaling regulation. By sequentially activating the Wnt/β-catenin pathway and gradually inhibiting BMP/Smad signaling, this system efficiently drives human pluripotent stem cells (PSC) to differentiate into high-purity glutamatergic neurons (VGLUT1/2⁺ > 85%), while simultaneously promoting the formation of Pax6⁺/BLBP⁺ radial glial cells that establish a biomimetic ventricular-zone–like structure.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100381

Nigericin sodium salt Maximum Cited Publications 221 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of *Wnt/β-catenin* signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

HY-N0020

Echinacoside 15+ Cited Publications	Structural Classification Simple Phenylpropanols Cistanche deserticola Ma Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants Source Classification	Wnt Reactive Oxygen Species (ROS)
Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity .

HY-N1499

Nystose	Structural Classification Polysaccharides Classification of Application Fields Rubiaceae Metabolic Disease Plants Morinda officinalis How Disease Research Fields Saccharides Source Classification	Wnt β-catenin TGF-beta/Smad Bacterial
Nystose is a tetrasaccharide with two fructose molecules linked via beta (1→2) bonds to the fructosyl moiety of sucrose. Nystose exhibits prebiotic, immunomodulatory, and metabolism regulating activities. Nystose promotes the bone mineralization by activating the *Wnt/β-catenin* signaling pathway .

HY-N0101

Neohesperidin 5+ Cited Publications Hesperetin 7-O-neohesperidoside	Flavonoids other families Classification of Application Fields Flavonones Rutaceae Phenols Polyphenols Plants Citrus Inflammation/Immunology Disease Research Fields Source Classification	β-catenin Wnt
Neohesperidin is a flavonoid compound abundant in citrus plants with antioxidant and anti-inflammatory effects. Neohesperidin can upregulate the *Wnt/β-catenin* signaling pathway, enhance the nuclear translocation of β-catenin and the differentiation of bone marrow stromal cells .

HY-N1411

Platycodin D 5+ Cited Publications	Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	AMPK Wnt
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. *WNT/β-catenin* pathway mediates the anti-adipogenic effect of platycodin D .

HY-100711

Prodigiosin 3 Publications Verification Prodigiosine; NSC47147	Anti-inflammation/Immunoregulatory Antifungal Classification of Application Fields Antibacterial Disease Research Other Antibiotics Food Research Infection Microorganisms Antibiotics Pigments Anticancer Inflammation/Immunology Disease Research Fields Source Classification	Bacterial Apoptosis Wnt Fungal Parasite
Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the *Wnt/β-catenin* pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-75342

Methyl vanillate 2 Publications Verification	Monophenols Microorganisms Oryza sativa Linn. Gramineae Phenols Plants Source Classification	Wnt Reactive Oxygen Species (ROS) Endogenous Metabolite
Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a *Wnt/β-catenin* pathway activator . A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

HY-113283

Homogentisic acid	Structural Classification Other disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin
Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ_1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the *Wnt/β-catenin* pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .

HY-N0559

Kirenol 1 Publications Verification	Structural Classification Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad
Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and *Wnt/β-catenin* pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis .

HY-N0432

Astragaloside I Astrasieversianin IV; Cyclosieversioside B	Triterpenes other families Classification of Application Fields Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Metabolic Disease Plants Disease Research Fields Source Classification	Wnt β-catenin
Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through activating the *Wnt/β-catenin* signaling pathway .

HY-N0279

Cardamonin 15+ Cited Publications Cardamomin; Alpinetin chalcone	Chalcones Flavonoids Classification of Application Fields Phenols Polyphenols Boesenbergia rotunda Plants Disease Research Fields Source Classification Zingiberaceae Cancer	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis
Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, *Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-129566

Withanolide B	Neurological Disease Classification of Application Fields Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	ERK Wnt β-catenin RUNX
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N0819

Raddeanin A 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK
Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, *Wnt/β-catenin, Wee1, PI3K/AKT* signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma .

HY-N0665

Specnuezhenide 1 Publications Verification (8E)-Nuezhenide	Structural Classification Monophenols Iridoids Oleaceae Classification of Application Fields Ligustrum lucidum Ait. Terpenoids Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB Wnt
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and *wnt/β-catenin* signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

HY-N1457

Chrysosplenetin 3 Publications Verification	Flavonols Structural Classification Piscidia erythrina L. Flavonoids Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Compositae Disease Research Fields Source Classification	P-glycoprotein Topoisomerase Apoptosis DNA/RNA Synthesis Wnt β-catenin Parasite
Chrysosplenetin is an orally active polymethoxyflavone. Chrysosplenetin exerts anticancer effects by inhibiting topoisomerase, protecting DNA and inducing apoptosis. Chrysosplenetin acts as an antimalarial sensitizer, reverses Artemisinin (HY-B0094) resistance by inhibiting and downregulating P-glycoprotein, and enhances the efficacy of Artemisinin. Chrysosplenetin promotes bone formation by activating the *Wnt/β-catenin* pathway and exerts anti-osteoporotic effects .

HY-N2375

L-Quebrachitol	Natural Products other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Source Classification	Wnt β-catenin p38 MAPK
L-Quebrachitol is a methoxy analog of inositol that can be isolated from plants. L-Quebrachitol has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and *Wnt/β-catenin* signaling pathway .

HY-N2156

Paeonolide	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Plants Paeoniaceae Inflammation/Immunology Disease Research Fields Paeonia suffruticosa Andr. Source Classification	ERK TGF-beta/Smad Wnt β-catenin JNK p38 MAPK
Paeonolide, found in Paeonia suffruticosa, is an ERK1/2 activator. Paeonolide promotes early and late osteoblast differentiation, stimulates pre-osteoblast transmigration, and activates the BMP-Smad1/5/8, *Wnt-β-catenin, JNK* and p38 pathways. Paeonolide can be used for the research of osteoporosis, periodontitis .

HY-N2785

Desmethylicaritin	Flavanonols Flavonoids Epimedium brevicornu Maxim. Plants Berberidaceae Source Classification	Wnt
Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway .

HY-N3149A

2-Hydroxycinnamaldehyde	Monophenols Cinnamomum cassia (L.) D. Don Phenols Plants Lauraceae Source Classification	Wnt β-catenin STAT Apoptosis
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits *Wnt/β-catenin, STAT3* signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities .

HY-W012352

2-Hydroxyanthraquinone	Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Morinda umbellata Rubiaceae Phenols Plants Disease Research Fields Source Classification Cancer	Glutathione Peroxidase Ferroptosis Wnt β-catenin Apoptosis
2-Hydroxyanthraquinone is a product generated by the photochemical oxidation of Anthracene (ANT) (HY-Y0299). 2-Hydroxyanthraquinone induces ferroptosis in cardiomyocytes by depleting GSH and inhibiting GPX4, leading to cardiac developmental malformations. 2-Hydroxyanthraquinone causes damage to the cerebrovascular system and blood-brain barrier in zebrafish by downregulating the *Wnt/β-catenin* signaling pathway, as well as inducing inflammation and neuronal apoptosis. 2-Hydroxyanthraquinone can be used in studies related to cerebrovascular diseases and cardiotoxicity .

HY-W100287

Murrayafoline A	Alkaloids Murraya tetramera C. C. Huang Rutaceae Carbazole Alkaloids Plants Source Classification	NF-κB p38 MAPK Interleukin Related IKK JNK β-catenin Wnt
Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the *Wnt/β-catenin* pathway by promoting the degradation of intracellular *β-catenin* proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer .

HY-N2523

Gigantol isomer-1 1 Publications Verification	Classification of Application Fields Orchidaceae Phenols Polyphenols Plants Disease Research Fields Dendrobium nobile Lindl. Source Classification Cancer	Wnt
Gigantol isomer-1 is a bibenzyl compound derived from Dendrobium nobile. Gigantol isomer-1 shows promising therapeutic potential against cancer cells. Gigantol isomer-1 is a novel inhibitor of the *Wnt/β-catenin* pathway.

HY-N7215

Jatrophone	Microorganisms Terpenoids Diterpenoids Source Classification	β-catenin Wnt
Jatrophone is a diterpenoid with anticancer activity isolated from Jatropha isabelli. Jatrophone interferes with the Wnt/β-catenin pathway to inhibit the proliferation and epithelial-mesenchymal transition (EMT) of triple-negative breast cancer cells.

HY-100711A

Prodigiosin hydrochloride 3 Publications Verification Prodigiosine hydrochloride	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Pigments Inflammation/Immunology Disease Research Fields Source Classification Food Research	Bacterial Apoptosis Fungal Wnt Parasite
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits *Wnt/β-catenin* pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-13675

ME-143 NV-143	Structural Classification Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields Source Classification Cancer	Wnt Endogenous Metabolite
ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo .

HY-N0020R

Echinacoside (Standard)	Structural Classification Simple Phenylpropanols Cistanche deserticola Ma Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants Source Classification	Reference Standards Wnt Reactive Oxygen Species (ROS)
Echinacoside (Standard) is the analytical standard of Echinacoside. This product is intended for research and analytical applications. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity .

HY-N1411R

Platycodin D (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Endogenous metabolite Source Classification	Reference Standards AMPK Wnt
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-111431R

p-Cresyl sulfate (Standard) p-Tolyl sulfate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards JNK p38 MAPK Reactive Oxygen Species (ROS)
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-N1499R

Nystose (Standard)	Structural Classification Polysaccharides Rubiaceae Plants Morinda officinalis How Saccharides Source Classification	Reference Standards Wnt β-catenin TGF-beta/Smad Bacterial
Nystose (Standard) is the analytical standard of Nystose. This product is intended for research and analytical applications. Nystose is a tetrasaccharide with two fructose molecules linked via beta (1→2) bonds to the fructosyl moiety of sucrose. Nystose exhibits prebiotic, immunomodulatory, and metabolism regulating activities. Nystose promotes the bone mineralization by activating the *Wnt/β-catenin* signaling pathway .

HY-N9647

Dalbinol	Flavonoids Leguminosae Amorpha fruticosaL. Plants Other Flavonoids Source Classification	Wnt β-catenin Apoptosis
Dalbinol is a rotenoid compound. Dalbinol can inhibit *Wnt/β-catenin* signaling pathway and promote *β-catenin* degradation. Dalbinol inhibits tumor cells proliferation and induces apoptosis. Dalbinol has antitumor activity .

HY-75342R

Methyl vanillate (Standard)	Structural Classification Monophenols Microorganisms Oryza sativa Linn. Gramineae Phenols Plants Source Classification	Reference Standards Wnt Reactive Oxygen Species (ROS) Endogenous Metabolite
Methyl vanillate (Standard) is the analytical standard of Methyl vanillate. This product is intended for research and analytical applications. Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a Wnt/β-catenin pathway activator[1]. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

HY-N0432R

Astragaloside I (Standard) Astrasieversianin IV (Standard); Cyclosieversioside B (Standard)	Triterpenes Structural Classification other families Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Source Classification	Reference Standards Wnt β-catenin
Astragaloside I (Standard) is the analytical standard of Astragaloside I. This product is intended for research and analytical applications. Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway .

HY-N0008R

Orcinol glucoside (Standard)	Curculigo orchioides Gaertn. Structural Classification Monophenols Phenols Plants Amaryllidaceae Source Classification	Reference Standards Wnt
Orcinol glucoside (Standard) is the analytical standard of Orcinol glucoside. This product is intended for research and analytical applications. Orcinol glucoside (OG) is an active constituent isolated from Curculigo orchioides, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway .

HY-129566R

Withanolide B (Standard)	Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards ERK Wnt β-catenin RUNX
Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N2375R

L-Quebrachitol (Standard)	Structural Classification Natural Products other families Plants Source Classification	Reference Standards Wnt β-catenin p38 MAPK
L-Quebrachitol is a methoxy analog of inositol that can be isolated from plants. L-Quebrachitol has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway .

HY-N2156R

Paeonolide (Standard)	Structural Classification Ketones, Aldehydes, Acids Plants Paeoniaceae Paeonia suffruticosa Andr. Source Classification	Reference Standards ERK TGF-beta/Smad Wnt β-catenin JNK p38 MAPK
Paeonolide (Standard) is the analytical standard of Paeonolide (HY-N2156). This product is intended for research and analytical applications. Paeonolide, found in Paeonia suffruticosa, is an ERK1/2 activator. Paeonolide promotes early and late osteoblast differentiation, stimulates pre-osteoblast transmigration, and activates the BMP-Smad1/5/8, *Wnt-β-catenin, JNK* and p38 pathways. Paeonolide can be used for the research of osteoporosis, periodontitis .

HY-N0665R

Specnuezhenide (Standard) (8E)-Nuezhenide (Standard)	Structural Classification Monophenols Iridoids Oleaceae Ligustrum lucidum Ait. Terpenoids Phenols Plants Source Classification	Reference Standards NF-κB Wnt
Specnuezhenide (Standard) is the analytical standard of Specnuezhenide. This product is intended for research and analytical applications. Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of?Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

HY-100381R

Nigericin sodium salt (Standard)	Structural Classification Microorganisms Antibiotics Disease Research Other Antibiotics Source Classification	Reference Standards Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt). This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of *Wnt/β-catenin* signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

HY-N7702

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide 1 Publications Verification	Natural Products other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Source Classification	Wnt β-catenin
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide is a macamide isolated from Maca (Lepidium meyenii Walp.) N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide induces mesenchymal stem cells osteogenic differentiation and consequent bone formation through activating the canonical *Wnt/β‐catenin* signaling pathway. N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide can be used for the research of osteoporosis .

HY-N0559R

Kirenol (Standard)	Structural Classification Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Reference Standards Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad
Kirenol (Standard) is the analytical standard of Kirenol (HY-N0559). This product is intended for research and analytical applications. Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis.

HY-N0819R

Raddeanin A (Standard)	Triterpenes Structural Classification other families Terpenoids Plants Source Classification	Reference Standards Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK
Raddeanin A (Standard) is the analytical standard of Raddeanin A (HY-N0819). This product is intended for research and analytical applications. Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma.

HY-N9858

Herpetin	Structural Classification Herpetospermum pedunculosum (Ser.) C. B. Clarke Cucurbitaceae Phenols Polyphenols Plants Source Classification	CXCR Wnt β-catenin
Herpetin is an active lignan. Herpetin acts as a bone marrow mesenchymal stem cell inducer that activates the SDF-1/CXCR4 axis and the *Wnt/β-catenin* pathway. Herpetin is applicable to research related to acute liver injury .

HY-N17639

Regiafuran C	Structural Classification Phenols Polyphenols Plants Moraceae Morus alba Linn. Source Classification	TGF-beta/Smad TGF-β Receptor
Regiafuran C is a compound with both TGF-βRI inhibitory and anti-fibrotic activities. Regiafuran C effectively inhibits renal fibrosis by binding to TGF-βRI and interfering with the TGF-β/Smad and *Wnt/β-catenin* signaling pathways. Regiafuran C also exhibits free radical scavenging activity, but shows no anti-inflammatory activity in PGE2 competitive enzyme immunoassays. The ability of Regiafuran C to specifically block the Smad3-TGF-βRII interaction and inhibit fibrotic processes allows its use in renal fibrosis research .

HY-N17736

Chikusetsusaponin IVa methyl ester CME	Structural Classification Terpenoids Achyranthes bidentata var. japonica Miq. Amaranthaceae Plants Pentacyclic Triterpenoids Source Classification	NF-κB COX Interleukin Related TNF Receptor NO Synthase Prostaglandin Receptor CDK β-catenin Wnt Apoptosis
Chikusetsusaponin IVa methyl ester (CME) is a natural triterpenoid saponin compound. Chikusetsusaponin IVa methyl ester induces G0/G1 cell cycle arrest and apoptosis in colon cancer cells by inhibiting the *Wnt/β-catenin* signaling pathway. By inhibiting the NF-κB and AP-1 signaling pathways, Chikusetsusaponin IVa methyl ester significantly reduces the production of NO, PGE₂ and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and downregulates the levels of iNOS and COX-2. Chikusetsusaponin IVa methyl ester can be used in researches on colorectal cancer and inflammation .

HY-W012352R

2-Hydroxyanthraquinone (Standard)	Quinones Structural Classification Monophenols Anthraquinones Morinda umbellata Rubiaceae Phenols Plants Source Classification	Reference Standards Glutathione Peroxidase Ferroptosis Wnt β-catenin Apoptosis
2-Hydroxyanthraquinone (Standard) is the analytical standard of 2-Hydroxyanthraquinone (HY-W012352). This product is intended for research and analytical applications. 2-Hydroxyanthraquinone is a product generated by the photochemical oxidation of Anthracene (ANT) (HY-Y0299). 2-Hydroxyanthraquinone induces ferroptosis in cardiomyocytes by depleting GSH and inhibiting GPX4, leading to cardiac developmental malformations. 2-Hydroxyanthraquinone causes damage to the cerebrovascular system and blood-brain barrier in zebrafish by downregulating the *Wnt/β-catenin* signaling pathway, as well as inducing inflammation and neuronal apoptosis. 2-Hydroxyanthraquinone can be used in studies related to cerebrovascular diseases and cardiotoxicity .

HY-W100287R

Murrayafoline A (Standard)	Structural Classification Alkaloids Murraya tetramera C. C. Huang Rutaceae Carbazole Alkaloids Plants Source Classification	NF-κB Reference Standards p38 MAPK Interleukin Related IKK JNK β-catenin Wnt
Murrayafoline A (Standard) is the analytical standard of Murrayafoline A (HY-W100287). This product is intended for research and analytical applications. Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer .

Cat. No.	Product Name	Chemical Structure

HY-75342S

Methyl vanillate-d3
Methyl vanillate-d₃ is deuterated labeled Methyl vanillate (HY-75342). Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a Wnt/β-catenin pathway activator . A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

HY-W714048

Laduviglusib-d4

Laduviglusib-d₄ (CHIR-99021-d₄) is the deuterium labeled Laduviglusib (HY-10182). Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy.

HY-W142432S

Perfluoroundecanoic acid-13C7

Perfluoroundecanoic acid- ¹³C₇ is the ¹³C-labeled Perfluoroundecanoic acid (HY-W142432). Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation .

HY-14930S

Mirodenafil-d7

Mirodenafil-d₇ (SK3530-d₇) is the deuterium labeled Mirodenafil (HY-14930). Mirodenafil (SK3530) is an orally active, potent, reversible, and selective?phosphodiesterase?5 (PDE5)?inhibitor. Mirodenafil is a?glucocorticoid receptor?(GR)?modulator Mirodenafil activates the?Wnt/β-catenin?signaling pathway by downregulating Dkk1 expression. Mirodenafil can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc).

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12238G

IWR-1 endo-IWR 1; IWR-1-endo	Organoid Wnt	Inflammation/Immunology Cancer
IWR-1 (IWR-1-endo) (GMP) is the IWR-1 (HY-12238) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting *Wnt/β-catenin* (IC₅₀ = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .

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