27 Results for "

acyl glucuronide metabolite

" in MedChemExpress (MCE) Product Catalog:
Products (27)

27 Results for "acyl glucuronide metabolite" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-41982
CAS No.: 32449-92-6
Synonyms: D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone
D-Glucuronic acid lactone (D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone) is an endogenous metabolite and a glucuronic acid derivative. D-Glucuronic acid lactone serves as a starting reagent for the synthesis of 2,3,4-tris (tert-butyldimethylsilyl) glucuronic acid trichloroethyl ester, which is used to prepare 1-O-acyl glucuronic acids for the anti-inflammatory agent mL-3000 (HY-B1452), synthesize optically active glucuronic acids, and produce long-chain alkyl glucuronides. D-Glucuronic acid lactone shows potential for use in studies of reversible cerebral vasoconstriction syndrome (RCVS) .
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Cat. No.: HY-126848
CAS No.: 64118-81-6
Purity:  95.6%
Synonyms: D-1-O-G
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, COX-1 inhibitory activity (IC50 = 0.620 μM), and COX-2 inhibitory activity (IC50 = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of OATP2B1. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers .
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Cat. No.: HY-W585920
CAS No.: 208038-27-1
Target:  

FXR

Research Areas:  

Metabolic Disease

Chenodeoxycholic acid 24-acyl-β-D-glucuronide is a metabolite of Chenodeoxycholic Acid (HY-76847) .
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Cat. No.: HY-B0890
CAS No.: 64092-48-4
Synonyms: McN-2783-21-98
Zomepirac sodium salt (McN-2783-21-98) is an orally active prostaglandin synthetase inhibitor. Zomepirac sodium salt blocks prostaglandin synthesis and inhibits Collagen (HY-P72147)- or Epinephrine (HY-B0447)-induced platelet aggregation. Zomepirac sodium salt can be used for the research of postoperative pain and osteoarthritis .
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Cat. No.: HY-137959
CAS No.: 250780-40-6
Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions .
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Cat. No.: HY-122813
CAS No.: 1015167-40-4
Research Areas:  

Cardiovascular Disease

Dabigatran acyl-β-D-glucuronide is an active metabolite of the thrombin inhibitor Dabigatran (HY-10163). Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.
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Cat. No.: HY-126121
CAS No.: 51146-55-5
Synonyms: (±)-2-Hydroxy Ibuprofen
2-Hydroxy Ibuprofen ((±)-2-Hydroxy Ibuprofen) is a major oxidative metabolite of Ibuprofen (HY-78131) . 2-Hydroxy Ibuprofen undergoes phase II metabolism, forming a β-1-O-acyl glucuronide conjugate at the carboxyl group of its propionic acid side chain. 2-Hydroxy Ibuprofen can be used for metabolism-related research .
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Cat. No.: HY-129889
CAS No.: 1351692-92-6
Synonyms: Febuxostat acyl-β-D-glucuronide
Research Areas:  

Metabolic Disease

Febuxostat acyl glucuronide (Febuxostat acyl-β-D-glucuronide) is a metabolite of Febuxostat (HY-14268). Febuxostat is a potent, selective and non-purine xanthine oxidase (XO) inhibitor .
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Cat. No.: HY-157129
CAS No.: 1943510-86-8
Target:  

AMPK

Research Areas:  

Cardiovascular Disease

AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy .
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Cat. No.: HY-135956
CAS No.: 910907-23-2
T3 Acyl glucuronide, an endogenous metabolite, is the acyl glucuronide formation of triiodothyronine (T3) .
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Cat. No.: HY-138290
CAS No.: 698358-10-0
Target:  

Drug Intermediate

Research Areas:  

Inflammation/Immunology

Diclofenac acyl-β-D-glucuronide allyl ester is an intermediate in the synthesis of the COX inhibitor metabolite Diclofenac acyl glucuronide (HY-126848) .
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Cat. No.: HY-113018A
CAS No.: 98649-76-4
Purity:  98.47%
Synonyms: (S)-Ibuprofen glucuronide
Target:  

Drug Metabolite

Research Areas:  

Inflammation/Immunology

(S)-Ibuprofen acyl-β-D-glucuronide ((S)-Ibuprofen glucuronide) is a compound used to study the metabolism and pharmacokinetics of S-ibuprofen, a non-steroidal anti-inflammatory drug. (S)-Ibuprofen acyl-β-D-glucuronide is an acylglucuronic acid metabolite produced by S-ibuprofen in the liver .
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Cat. No.: HY-W699926
CAS No.: 112828-15-6
Synonyms: (R)-Naproxen-β-D-glucuronide
(R)-Naproxen acyl-β-D-glucuronide ((R)-Naproxen-β-D-glucuronide) is a compound metabolite with anti-inflammatory activity. (R)-Naproxen acyl-β-D-glucuronide can serve as a sensitive fluorescent substrate for proglutamyl peptidase 1, which produces a blue reaction after cleavage.
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Cat. No.: HY-137188
CAS No.: 120398-66-5
Target:  

Drug Metabolite

Research Areas:  

Cardiovascular Disease

Perindopril acyl-β-D-glucuronide is a metabolite of Perindopril (HY-B0130). Perindopril is an ACE inhibitor .
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Cat. No.: HY-136344
CAS No.: 463962-56-3
Target:  

Drug Metabolite

Research Areas:  

Others

Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM .
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Cat. No.: HY-126121S
CAS No.: 1217055-71-4
Synonyms: (±)-2-Hydroxy Ibuprofen-d6
2-Hydroxy Ibuprofen-d6 ((±)-2-Hydroxy Ibuprofen-d6)is the deuterated-labeled 2-Hydroxy Ibuprofen (HY-126121). 2-Hydroxy Ibuprofen is a major oxidative metabolite of Ibuprofen (HY-78131) . 2-Hydroxy Ibuprofen undergoes phase II metabolism, forming a β-1-O-acyl glucuronide conjugate at the carboxyl group of its propionic acid side chain. 2-Hydroxy Ibuprofen can be used for metabolism-related research .
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Cat. No.: HY-186081
CAS No.: 1357570-22-9
Target:  

Drug Metabolite

Research Areas:  

Metabolic Disease

Ramiprilat acyl-β-D-glucuronide is an acyl glucuronide metabolite of Ramiprilat (HY-B0279). Ramiprilat acyl-β-D-glucuronide undergoes methylation on its glucuronic acid moiety during solid phase extraction with strong cation exchanger cartridges, forming a methylated derivative. Ramiprilat acyl-β-D-glucuronide undergoes in-source conversion to Ramiprilat in mass spectrometry, with conversion extent proportional to declustering potential voltage .
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Cat. No.: HY-B0890A
CAS No.: 33369-31-2
Synonyms: McN-2783-21-98 free acid
Zomepirac (McN-2783-21-98 free acid) is an orally active prostaglandin synthetase inhibitor. Zomepirac blocks prostaglandin synthesis and inhibits Collagen (HY-P72147)- or Epinephrine (HY-B0447)-induced platelet aggregation. Zomepirac can be used for the research of postoperative pain and osteoarthritis .
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Cat. No.: HY-B0890R
CAS No.: 64092-48-4
Synonyms: McN-2783-21-98 (Standard)
Zomepirac sodium salt (Standard) is the analytical standard of Zomepirac sodium salt (HY-B0890). This product is intended for research and analytical applications. Zomepirac sodium salt (McN-2783-21-98) is an orally active prostaglandin synthetase inhibitor. Zomepirac sodium salt blocks prostaglandin synthesis and inhibits Collagen (HY-P72147)- or Epinephrine (HY-B0447)-induced platelet aggregation. Zomepirac sodium salt can be used for the research of postoperative pain and osteoarthritis .
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Cat. No.: HY-126121R
CAS No.: 51146-55-5
Synonyms: (±)-2-Hydroxy Ibuprofen (Standard)
2-Hydroxy Ibuprofen (Standard) ((±)-2-Hydroxy Ibuprofen (Standard)) is the analytical standard of 2-Hydroxy Ibuprofen (HY-126121). This product is intended for research and analytical applications. 2-Hydroxy Ibuprofen ((±)-2-Hydroxy Ibuprofen) is a major oxidative metabolite of Ibuprofen (HY-78131) . 2-Hydroxy Ibuprofen undergoes phase II metabolism, forming a β-1-O-acyl glucuronide conjugate at the carboxyl group of its propionic acid side chain. 2-Hydroxy Ibuprofen can be used for metabolism-related research .
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