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Results for "

alpha-smooth muscle actin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Aminoacyl-tRNA Synthetase (1) Cadherin (1) Collagen (2) CXCR (1) Drug Isomer (1) Epigenetic Reader Domain (1) Galectin (1) MMP (2) P2Y Receptor (1) Phosphodiesterase (PDE) (1) Ras (1) ROCK (1) STAT (1) TGF-β Receptor (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Inflammation/Immunology (6) Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Antibodies

Targets Recommended: Arp2/3 Complex

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121750

CCG-222740 1 Publications Verification	Ras ROCK	Cancer
CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor . CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis .

HY-12093A

(R)-MMP408	Drug Isomer MMP Cadherin	Inflammation/Immunology
(R)-MMP408 is an isomer of MMP408 (HY-12093). MMP408 is an orally active MMP-12 inhibitor (IC₅₀=2.0 nM for hMMP-12) that effectively interferes with the epithelial-mesenchymal transition (EMT) process. MMP408 significantly upregulates the expression of E-cadherin in nasal epithelial cells, while inhibiting mesenchymal markers such as vimentin, α-smooth muscle actin and fibronectin, thereby reversing the EMT phenotype. MMP408 is used in studies of airway remodeling-related diseases, including chronic rhinosinusitis with nasal polyps, chronic obstructive pulmonary disease (COPD) and asthma .

HY-P11112

PTD-DBM	β-catenin Wnt Collagen	Inflammation/Immunology
PTD-DBM is a CXXC5-Dvl protein-protein interaction inhibitor and also a Wnt/β-catenin pathway activator. PTD-DBM interferes with the Dvl-binding function of CXXC5, disrupts the negative feedback regulation of the Wnt/β-catenin pathway, induces β-catenin expression and nuclear translocation, and increases the production of type I collagen, α-smooth muscle actin and endothelin-1. PTD-DBM is applicable to studies related to androgenetic alopecia and skin wound healing .

HY-145555

Bersiporocin DWN12088	Aminoacyl-tRNA Synthetase	Inflammation/Immunology
Bersiporocin (DWN12088) is an orally effective prolyl-tRNA synthetase (PRS) inhibitor. Bersiporocin exerts antifibrotic effects by inhibiting collagen synthesis. Bersiporocin can be used in the research of pulmonary fibrosis .

HY-173235

Galectin-3-IN-6	Galectin	Cardiovascular Disease Inflammation/Immunology Cancer
Galectin-3-IN-6 is a human and murine galectin-3 (Gal-3) inhibitor, with an IC₅₀ of 12 nM against human galectin-3, an IC₅₀ of 12.6 nM against mutant murine galectin-3 (V160A), and a K_d of 13 nM for human galectin-3, as well as oral bioavailability. Galectin-3-IN-6 reduces the levels of liver fibrosis markers type I collagen and α-smooth muscle actin in mouse models of acute liver injury and fibrosis. Galectin-3-IN-6 can be used for the research of acute liver injury and fibrosis .

HY-116307

2-Thio-UTP	P2Y Receptor	Cardiovascular Disease
2-Thio-UTP is a selective P2Y₂ inhibitor with an EC₅₀ value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) .

HY-170227

Autotaxin-IN-7	Phosphodiesterase (PDE) TGF-β Receptor	Inflammation/Immunology
Autotaxin-IN-7 (45), a pyridine-2-carboxylic derivative, demonstrates subnanomolar ATX inhibition (IC₅₀ = 0.086 nM), with a favorable heart safety profile (hERG > 30 μM) and minimal fibroblast toxicity. Autotaxin-IN-7 (45) suppresses the TGF-β/Smad signaling pathway, downregulating α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) is used in the research for pulmonary fibrosis .

HY-162902

ALK5-IN-82	TGF-β Receptor	Cardiovascular Disease
ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC₅₀ value of 9.1 nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1)/matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis .

HY-N11736

12-O-Tiglyl-phorbol 13-dodecanoate	Collagen	Metabolic Disease
12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis .

HY-182273

DM243	STAT Acyltransferase	Others
DM243 is an EPAC1 activator and STAT3 modulator with an pIC₅₀ of 4.769 for EPAC1. DM243 increases GTP-bound Rap1 levels in EPAC1-expressing cells. DM243 reduces IL-6/IL-6Rα-evoked STAT3 phosphorylation in endothelial cells. DM243 suppresses TGF-β1-induced fibroblast-to-myofibroblast transition, reducing α-smooth muscle actin and Collagen I levels in lung fibroblasts. DM243 exhibits minimal cytotoxicity in normal human lung fibroblasts .

HY-181654

Snail IN-1	Epigenetic Reader Domain CXCR MMP	Inflammation/Immunology
Snail IN-1 is an orally active Snail inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts Snail-CBP interaction, accelerates Snail protein degradation, reduces Snail acetylation, increases Snail polyubiquitination, and selectively downregulates Snail protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5, CXCL10, MMP2, and MMP9, and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis .

Cat. No.	Product Name	Target	Research Area

HY-P11112

PTD-DBM	β-catenin Wnt Collagen	Inflammation/Immunology
PTD-DBM is a CXXC5-Dvl protein-protein interaction inhibitor and also a Wnt/β-catenin pathway activator. PTD-DBM interferes with the Dvl-binding function of CXXC5, disrupts the negative feedback regulation of the Wnt/β-catenin pathway, induces β-catenin expression and nuclear translocation, and increases the production of type I collagen, α-smooth muscle actin and endothelin-1. PTD-DBM is applicable to studies related to androgenetic alopecia and skin wound healing .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11736

12-O-Tiglyl-phorbol 13-dodecanoate	Structural Classification Natural Products Euphorbia fischeriana Steud. Euphorbiaceae Plants Source Classification	Collagen
12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis .

Host:	Mouse (6) Rabbit (3)
Reactivity:	Human (9) Rat (8) Mouse (9) Monkey (3) Rabbit (2)
Application:	IHC-P (9) ICC/IF (6) mIHC (1) IF-Tissue (3) IP (2) IHC-F (2) WB (9) FC (7) ELISA (4)
Isotype:	IgG,Kappa (1) IgG (4) IgG1 (2)
Conjugation:	Non-conjugated (9)
Clonality:	Monoclonal (7) Recombinant (3)
Modification:	Unmodified (7)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87795

	α smooth muscle actin Antibody (YA7480)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	α smooth muscle actin Antibody (YA7480) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to α smooth muscle actin.

HY-P84429

	alpha Smooth Muscle Actin Antibody (YA4126) ACTA2; AAT6; ACTSA; ACTA2; α-smooth muscle actin; alpha-actin-2; alpha actin 2	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	alpha Smooth Muscle Actin Antibody (YA4126) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to alpha Smooth Muscle Actin.

HY-P84429A

	alpha Smooth Muscle Actin Antibody (YA4126)(PBS only) ACTA2; AAT6; ACTSA; ACTA2; α-smooth muscle actin; alpha-actin-2; alpha actin 2	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	alpha Smooth Muscle Actin Antibody (YA4126) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to alpha Smooth Muscle Actin.

HY-P80484

	alpha smooth muscle Actin Antibody (YA627) 4 Publications Verification alpha sarcomeric actin; alpha smooth muscle actin; actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; actin, aortic smooth muscle; alpha 2 actin; alpha actin 2; alpha cardiac actin; alpha-actin 2; alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-smooth muscle actin; α smooth muscle actin;	WB, IHC-P, FC, IP	Human, Mouse
	alpha smooth muscle Actin Antibody is a non-conjugated and Rabbit origined IgG monoclonal antibody, targeting to alpha smooth muscle Actin. It can be used as a loading control antibody.

HY-P83739

	alpha smooth muscle Actin Antibody(YA3468) alpha sarcomeric actin; alpha smooth muscle actin; actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; actin, aortic smooth muscle; alpha 2 actin; alpha actin 2; alpha cardiac actin; alpha-actin 2; alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-smooth muscle actin; α smooth muscle actin;	WB, IHC-P, ICC/IF, FC, IF-Tissue, mIHC	Human, Mouse, Rat
	alpha smooth muscle Actin Antibody(YA3468) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha smooth muscle Actin.

HY-P86727

	alpha smooth muscle Actin Antibody (YA6419) alpha sarcomeric actin; alpha smooth muscle actin; actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; actin, aortic smooth muscle; alpha 2 actin; alpha actin 2; alpha cardiac actin; alpha-actin 2; alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5	WB, IHC-P, IHC-F, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat
	alpha smooth muscle Actin Antibody (YA6419) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to alpha smooth muscle Actin.

HY-P86727A

	alpha smooth muscle Actin Antibody (YA6419)(PBS only) alpha sarcomeric actin; alpha smooth muscle actin; actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; ACTSA; ACTVS; alpha 2 actin; alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; actin, aortic smooth muscle; alpha 2 actin; alpha actin 2; alpha cardiac actin; alpha-actin 2; alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5	WB, IHC-P, IHC-F, IF-Tissue, FC	Human, Mouse, Rat
	alpha smooth muscle Actin Antibody (YA6419) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to alpha smooth muscle Actin.

HY-P85028

	alpha Smooth Muscle Actin Antibody (YA4720) ACTA2; ACTSA; ACTVS; GIG46; actin; aortic smooth muscle; alpha-actin-2; Cell growth-inhibiting gene 46 protein	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
	alpha Smooth Muscle Actin Antibody (YA4720) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to alpha Smooth Muscle Actin.

HY-P85726

	alpha Smooth Muscle Actin Antibody (YA5418) ACTA2; ACTSA; ACTVS; GIG46; actin, aortic smooth muscle; alpha-actin-2; Cell growth-inhibiting gene 46 protein	WB, IHC-P	Human, Mouse, Rat
	alpha Smooth Muscle Actin Antibody (YA5418) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to alpha Smooth Muscle Actin.

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alpha-smooth muscle actin

Inhibitors & Agonists

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Natural
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