3106606-59-8
Chemical Structure
DM243
- CAS No.: 3106606-59-8
- Formula:C22H21NO6
- Molecular Weight:395.41
InChIKey: LJQVDXLYOKFHNW-UHFFFAOYSA-N
SMILES: O=C(O)C(NCC1=CC=C(OC(C(C2=CC=CC=C2OC)=O)=C3C(C)C)C3=C1)=O
Biological Activity: DM243 is an EPAC1 activator and STAT3 modulator with an pIC50 of 4.769 for EPAC1. DM243 increases GTP-bound Rap1 levels in EPAC1-expressing cells. DM243 reduces IL-6/IL-6Rα-evoked STAT3 phosphorylation in endothelial cells. DM243 suppresses TGF-β1-induced fibroblast-to-myofibroblast transition, reducing α-smooth muscle actin and Collagen I levels in lung fibroblasts. DM243 exhibits minimal cytotoxicity in normal human lung fibroblasts[1].
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DM243 | DM243 is an EPAC1 activator and STAT3 modulator with an pIC50 of 4.769 for EPAC1. DM243 increases GTP-bound Rap1 levels in EPAC1-expressing cells. DM243 reduces IL-6/IL-6Rα-evoked STAT3 phosphorylation in endothelial cells. DM243 suppresses TGF-β1-induced fibroblast-to-myofibroblast transition, reducing α-smooth muscle actin and Collagen I levels in lung fibroblasts. DM243 exhibits minimal cytotoxicity in normal human lung fibroblasts. | |||||||||||||||||||||
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Keywords
