35763-29-2
35763-29-2
Chemical Structure
2-Thio-UTP
- CAS No.: 35763-29-2
- Formula:C9H15N2O14P3S
- Molecular Weight:500.21
IUPAC Name: ((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: KHYOUGAATNYCAZ-XVFCMESISA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Biological Activity: 2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) [1][2].
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2-Thio-UTP | 2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) . | |||||||||||||||||||||
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References
- [1]. El-Tayeb A, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. [Content Brief]
- [2]. Moschetta D, et al. Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation. Biomedicines. 2022 Feb 16;10(2):457. [Content Brief]
