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Results for "

angiopoietin-2

" in MedChemExpress (MCE) Product Catalog:

標的別:	Tie (5) VEGFR (2)
研究分野別:	Cancer (5) Cardiovascular Disease (3) Inflammation/Immunology (5) Metabolic Disease (1)

阻害剤およびアゴニスト

阻害性抗体

組換えタンパク質

抗体

Targets Recommended: Tie ANGPTL

製品番号	製品名	Target	研究分野	構造式

HY-P99116

Faricimab RG7716; RO-6867461	VEGFR	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Faricimab, an overall good safety and tolerability profile, is a bispecific antibody targeting Angiopoietin-2 (Ang-2) and vascular endothelial growth factor-A (VEGF-A). Faricimab prevents retinal vascular leakage, cell death and inflammation in retinal ischemia/reperfusion (I/R) injury and sCNV mouse models. Faricimab demonstrates statistically superior visual acuity gains versus Ranibizumab (HY-P9951). Faricimab can be used for retinal diseases, such as age-related macular degeneration (w-AMD), diabetic macular edema (DME) and macular edema following retinal vein occlusion (RVO) ^[2] .

HY-P99330

Vanucizumab Anti-Human VEGFA Recombinant Antibody; RO5520985	VEGFR Tie	Cancer
Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and **angiopoietin-2 (Ang-2)** from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects .

HY-P99036

Nesvacumab	Tie	Cardiovascular Disease Inflammation/Immunology Cancer
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand *Angiopoietin-2* (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches ^[2].

HY-P99510

Zansecimab LY-3127804	Tie	Inflammation/Immunology Cancer
Zansecimab (LY-3127804) is a monoclonal antibody against angiopoietin 2 (Ang‑2). Zansecimab can be used in research on angiogenesis, immunomodulation and anti-tumor activity ^[2] .

HY-P99546

Trebananib 2xCon4C; AMG 386	Tie	Cardiovascular Disease Cancer
Trebananib (2xCon4C) is an Fc fusion peptibody. Trebananib exerts its effects by blocking the binding of angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) to the *TIE2* receptor. Trebananib has anti-angiogenic and anti-tumor activities ^[2] .

HY-P991663

AMG-780	Tie	Cancer
AMG-780 is a fully human IgG2 antibody that targets angiopoietin 1 (Ang1) (IC₅₀ = 4.5 nM) and angiopoietin 2 (Ang2) (IC₅₀ = 0.06 nM). AMG-780 inhibits tumor growth in the Colo205 xenograft mouse model by inhibiting both Ang1 and *Ang2*. AMG-780 is indicated for the research of cancers such as colon cancer ^[2].

製品番号	製品名	Target	研究分野	Image

HY-P99116

Faricimab RG7716; RO-6867461	VEGFR	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Faricimab, an overall good safety and tolerability profile, is a bispecific antibody targeting Angiopoietin-2 (Ang-2) and vascular endothelial growth factor-A (VEGF-A). Faricimab prevents retinal vascular leakage, cell death and inflammation in retinal ischemia/reperfusion (I/R) injury and sCNV mouse models. Faricimab demonstrates statistically superior visual acuity gains versus Ranibizumab (HY-P9951). Faricimab can be used for retinal diseases, such as age-related macular degeneration (w-AMD), diabetic macular edema (DME) and macular edema following retinal vein occlusion (RVO) ^[2] .

HY-P99330

Vanucizumab Anti-Human VEGFA Recombinant Antibody; RO5520985	VEGFR Tie	Cancer
Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and **angiopoietin-2 (Ang-2)** from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects .

HY-P99036

Nesvacumab	Tie	Cardiovascular Disease Inflammation/Immunology Cancer
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand *Angiopoietin-2* (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches ^[2].

HY-P99510

Zansecimab LY-3127804	Tie	Inflammation/Immunology Cancer
Zansecimab (LY-3127804) is a monoclonal antibody against angiopoietin 2 (Ang‑2). Zansecimab can be used in research on angiogenesis, immunomodulation and anti-tumor activity ^[2] .

HY-P99546

Trebananib 2xCon4C; AMG 386	Tie	Cardiovascular Disease Cancer
Trebananib (2xCon4C) is an Fc fusion peptibody. Trebananib exerts its effects by blocking the binding of angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) to the *TIE2* receptor. Trebananib has anti-angiogenic and anti-tumor activities ^[2] .

HY-P990625

MEDI-3617	阻害性抗体	Inflammation/Immunology
MEDI-3617 is a humanized antibody expressed in CHO cells, targeting *Ang2/ANGPT2/Angiopoietin2*. MEDI-3617 has a huIgG2 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for MEDI-3617 can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P990334

Anti-ANGPT2 Antibody	阻害性抗体	Inflammation/Immunology
Anti-ANGPT2 Antibody is a CHO-expressed human antibody that targets *Ang2/ANGPT2/Angiopoietin2. Anti-ANGPT2 Antibody has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti*-ANGPT2 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991663

AMG-780	Tie	Cancer
AMG-780 is a fully human IgG2 antibody that targets angiopoietin 1 (Ang1) (IC₅₀ = 4.5 nM) and angiopoietin 2 (Ang2) (IC₅₀ = 0.06 nM). AMG-780 inhibits tumor growth in the Colo205 xenograft mouse model by inhibiting both Ang1 and *Ang2*. AMG-780 is indicated for the research of cancers such as colon cancer ^[2].

Species:	Human (9) Rhesus Macaque (4) Mouse (3) Cynomolgus (4) Dog (2)
Tag:	His (14) Avi (4) Fc (4)
Source:	HEK293 (16) CHO (2)

製品番号	Compare	製品名	Species	Source	Image

HY-P704354

	Angiopoietin-2 Protein, Mouse (CHO, His) angiopoietin-2; ANG-2; ANGPT2	Mouse	CHO
	Angiopoietin 2 protein (ANGPT2) binds to TEK/TIE2, competes with ANGPT1, and modulates its signaling. Even in the absence of ANGPT1, ANGPT2 induces TEK/TIE2 phosphorylation. Angiopoietin-2 Protein, Mouse (CHO, His) is the recombinant mouse-derived Angiopoietin-2 protein, expressed by CHO, with C-His labeled tag.

HY-P72828

	Angiopoietin-2 Protein, Human (CHO, His) angiopoietin-2; ANG-2; ANGPT2	Human	CHO
	Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (CHO, His) is the recombinant human-derived Angiopoietin-2 protein, expressed by CHO , with C-6*His labeled tag.

HY-P72827

	Angiopoietin-2 Protein, Human (HEK293, Fc) angiopoietin-2; ANG-2; ANGPT2	Human	HEK293
	Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (HEK293, Fc) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72830

	Angiopoietin-2 Protein, Mouse (HEK293, His) angiopoietin-2; ANG-2; ANGPT2	Mouse	HEK293
	Angiopoietin 2 protein (ANGPT2) binds to TEK/TIE2, competes with ANGPT1, and modulates its signaling. Even in the absence of ANGPT1, ANGPT2 induces TEK/TIE2 phosphorylation. Angiopoietin-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P76149

	Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) angiopoietin-2; ANG-2; ANGPT2	Rhesus Macaque;Cynomolgus	HEK293
	Angiopoietin-2 (Ang2) is a growth factor that belongs to the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway, which is one of the main pathways involved in angiogenesis. Ang2 is a 496 amino acid long protein with a secretory signal peptide, an NH2-terminal coiled-coil domain, and a COOH-terminal fibrinogen-like domain. Ang2 mainly inhibits Ang1-induced Tie2 phosphorylation. Ang2 is critical for endothelial cell physiology and plays a central role in vascular-related diseases by regulating endothelial permeability and angiogenic functions. Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72829

	Angiopoietin-2 Protein, Human (478a.a, HEK293, His) 1 Publications Verification angiopoietin-2; ANG-2; ANGPT2	Human	HEK293
	Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (478a.a, HEK293, His) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78381

	Angiopoietin-2 Protein, Human (HEK293, His-Avi) AGPT2; ANG2; ANG-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand	Human	HEK293
	Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P7510

	Angiopoietin-2 Protein, Human (HEK293, His) 2 Publications Verification rHuangiopoietin-2, His; ANGPT2; ANG2; angiopoietin-2	Human	HEK293
	Angiopoietin-2 Protein, Human (HEK293, His) is a circulating antagonistic ligand of the endothelial-specific Tie2 receptor and has been identified as an important gatekeeper of endothelial activation.

HY-P703964

	*FITC-Labeled Angiopoietin-2* Protein, Human (HEK293, His)** AGPT2; ANG2; ANG-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand	Human	HEK293
	Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. FITC-Labeled Angiopoietin-2 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled Angiopoietin-2 protein, expressed by HEK293, with N-His labeled tag.

HY-P78061

	Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi) AGPT2; ANG2; ANG-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand	Human	HEK293
	Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P76148

	Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (222a.a, HEK293, His) angiopoietin-2; ANG-2; ANGPT2	Rhesus Macaque;Cynomolgus	HEK293
	Angiopoietin-2 (Ang2) is a growth factor that belongs to the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway, which is one of the main pathways involved in angiogenesis. Ang2 is a 496 amino acid long protein with a secretory signal peptide, an NH2-terminal coiled-coil domain, and a COOH-terminal fibrinogen-like domain. Ang2 mainly inhibits Ang1-induced Tie2 phosphorylation. Ang2 is critical for endothelial cell physiology and plays a central role in vascular-related diseases by regulating endothelial permeability and angiogenic functions. Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (222a.a, HEK293, His) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P76147

	Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (222a.a, HEK293, Fc) angiopoietin-2; ANG-2; ANGPT2	Rhesus Macaque;Cynomolgus	HEK293
	Angiopoietin-2 (Ang2) is a growth factor that belongs to the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway, which is one of the main pathways involved in angiogenesis. Ang2 is a 496 amino acid long protein with a secretory signal peptide, an NH2-terminal coiled-coil domain, and a COOH-terminal fibrinogen-like domain. Ang2 mainly inhibits Ang1-induced Tie2 phosphorylation. Ang2 is critical for endothelial cell physiology and plays a central role in vascular-related diseases by regulating endothelial permeability and angiogenic functions. Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (222a.a, HEK293, Fc) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P7844

	Angiopoietin-2 Protein, Mouse (HEK293, Fc) rMuangiopoietin-2/ANG2, Fc ; AGPT2; ANG2; ANG-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand	Mouse	HEK293
	Angiopoietin 2 protein (ANGPT2) binds to TEK/TIE2, competes with ANGPT1, and modulates its signaling. Even in the absence of ANGPT1, ANGPT2 induces TEK/TIE2 phosphorylation. Angiopoietin-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Angiopoietin-2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70123

	Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (HEK293, hFc) rRhANG2, Fc; AGPT2; ANG2; ANG-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand	Rhesus Macaque;Cynomolgus	HEK293
	ANGPT2 is a secreted factor on the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway and is involved in tumor angiogenesis. In the presence of ANGPT1, ANGPT2 antagonizes ANGPT1-mediated Tie2 phosphorylation, leading to vessel sprouting or degeneration depending on the level of VEGF-A. Overexpression or inhibition of ANGPT2 increases or decreases angiogenic capacity, respectively. Angiopoietin-2 Protein, Cynomolgus/Rhesus Macaque (HEK293, hFc) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704975

	Angiopoietin-2 Protein, Human (Biotinylated, 478a.a, HEK293, His-Avi) AGPT2; ANG2; ANG-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; Tie2-ligand	Human	HEK293

HY-P78651

	*FITC-Labeled Angiopoietin-2* Protein, Human (HEK293, His-Avi)** ANGPT2; AGPT2; ANG2; angiopoietin-2	Human	HEK293
	Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. FITC-Labeled Angiopoietin-2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived FITC-Labeled Angiopoietin-2 protein, expressed by HEK293 , with N-His-Avi labeled tag.

HY-P700396

	*ANGPT2/Angiopoietin-2* Protein, Dog (HEK293, His)** angiopoietin 2; angiopoietin-2; Ang2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; ANG2; AGPT2;	Dog	HEK293
	ANGPT2/Angiopoietin-2 (dog) complexly regulates angiogenesis by binding to TEK/TIE2, competitively affecting ANGPT1 signaling. It independently induces TEK/TIE2 phosphorylation and, in the absence of VEGF, may cause endothelial cell apoptosis, thereby promoting vascular regression. ANGPT2/Angiopoietin-2 Protein, Dog (HEK293, His) is the recombinant dog-derived ANGPT2/Angiopoietin-2, Dog, expressed by HEK293 , with C-6*His labeled tag.

HY-P75509

	*ANGPT2/Angiopoietin-2* Protein, Dog (222a.a, HEK293, His)** angiopoietin-2; ANG-2; ANGPT2	Dog	HEK293
	ANGPT2/Angiopoietin-2 (dog) complexly regulates angiogenesis by binding to TEK/TIE2, competitively affecting ANGPT1 signaling. It independently induces TEK/TIE2 phosphorylation and, in the absence of VEGF, may cause endothelial cell apoptosis, thereby promoting vascular regression. ANGPT2/Angiopoietin-2 Protein, Dog (222a.a, HEK293, His) is the recombinant dog-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag.

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HY-P81853

	Angiopoietin 2 Antibody (YA1598) angiopoietin-2 (ANG-2)	WB, IHC-P	Human, Mouse, Rat
	Angiopoietin 2 Antibody (YA1598) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Angiopoietin 2.

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