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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
239 Results for "
beta-amyloid
" in MedChemExpress (MCE) Product Catalog:
Products (239)
239 Results for "beta-amyloid" in MCE Product Catalog:
172
172 Publications Verification
Synonyms: trans-Resveratrol; SRT501
45
45 Cited Publications
Cat. No.: HY-P0128
CAS No.: 131602-53-4
Synonyms: amyloid beta-peptide (25-35); Aβ25-35; β-amyloid peptide (25-35)
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45
45 Cited Publications
Cat. No.: HY-P0128A
CAS No.: 131602-53-4
Synonyms: amyloid beta-peptide (25-35), HFIP-treated; Aβ25-35, HFIP-treated; β-amyloid peptide (25-35), HFIP-treated
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27
27 Cited Publications
Cat. No.: HY-P1363B
CAS No.: 107761-42-2
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27
27 Cited Publications
Cat. No.: HY-P1363A
CAS No.: 107761-42-2
Synonyms: amyloid β-peptide (1-42) (human)
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19
19 Cited Publications
Cat. No.: HY-16900
CAS No.: 61413-54-5
Synonyms: (R,S)-Rolipram; (±)-Rolipram; ZK 62711
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Rolipram is a PDE4 inhibitor, with blood-brain barrier permeability, that reverses β-amyloid-induced learning and memory impairment in rats. Rolipram elevates intracellular cAMP and clevels and regulates the cAMP/CREB signaling pathway, thereby alleviating neuroinflammation and apoptotic responses. Rolipram promotes neuronal differentiation of human bone marrow mesenchymal stem cells and inhibits Methamphetamine- and morphine-induced hyperlocomotion in mice. Rolipram also reduces the viability of glioblastoma stem-like cells and enhances Bevacizumab (HY-P9906)-induced cell death. Rolipram inhibits the expression of proinflammatory cytokines and enhances central noradrenergic transmission. Rolipram is mainly used in studies related to various central nervous system diseases including Alzheimer's disease, major depressive disorder, glioblastoma multiforme, and multiple sclerosis .
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18 Cited Publications
Synonyms: γ-Secretase-IN-1
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Compound E is a γ-secretase inhibitor. Compound E blocks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
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14 Cited Publications
12
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Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM. Semagacestat can be used for the research of alzheimer's disease .
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11 Cited Publications
Cat. No.: HY-P0265C
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11
11 Cited Publications
Cat. No.: HY-P0265A
Synonyms: amyloid β-Peptide (1-40) (human) TFA; Aβ40 (human) TFA; Aβ(1-40) (human) TFA
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10
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Carbenoxolone is a blood-brain barrier-permeable Pannexin1 inhibitor, gap junction (Gap junction) blocker, and β-amyloid 42 inhibitor. Carbenoxolone modulates voltage-gated currents of wild-type and mutant Panx1, and inhibits stimulus-activated Panx1 channel function. Carbenoxolone interacts with stable residues of β-amyloid 42 peptides, fibrils and oligomers, thereby inhibiting their aggregation. Carbenoxolone alleviates liver fibrosis. Carbenoxolone exerts neuroprotective and nootropic effects. Carbenoxolone can be used in studies related to Alzheimer's disease and liver fibrosis .
8
8 Cited Publications
Cat. No.: HY-P1388
CAS No.: 166090-74-0
Synonyms: amyloid β-peptide (1-42) (rat/mouse)
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8
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4
4 Cited Publications
Cat. No.: HY-N0044
CAS No.: 52286-59-6
Synonyms: Ginsenoside B2; Panaxoside Re; Sanchinoside Re
Category:
Panax ginseng C. A. Meyer Triterpenes Neurological Disease Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer
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3
3 Cited Publications
Cat. No.: HY-P0198A
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3
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2
2 Cited Publications
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5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
