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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
cAMP-phosphodiesterase
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "cAMP-phosphodiesterase" in MCE Product Catalog:
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1 Cited Publications
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1 Cited Publications
Synonyms: Theophyllineacetic acid; Theophylline-7-acetic acid
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Triflusal is an orally bioavailable, blood-brain barrier-permeable dual Cyclooxygenase-1 (COX-1)/cAMP phosphodiesterase inhibitor. Triflusal inhibits platelet aggregation, NF-κB activation, iNOS activity, and prostaglandin synthesis in ischaemic tissue. Triflusal stimulates neutrophil nitric oxide production, eNOS protein expression, and cNOS activity. Triflusal alleviates cerebral ischemic injury in rats and ameliorates pathological lesions and related gene expression in transgenic Alzheimer’s disease models. Triflusal can be used for the research of thromboembolic/ischemic cardiovascular and cerebrovascular diseases, and Alzheimer’s disease .
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Reproterol is a selective β2-adrenoceptor agonist and cAMP phosphodiesterase (PDE) inhibitor. Reproterol inhibits adenylate cyclase-induced phosphodiesterase activity. Reproterol inhibits histamine release from mast cells. Reproterol is applicable to research related to asthma .
Synonyms: CGS-9343B; KW 5617
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Neurological Disease Metabolic Disease Inflammation/Immunology
Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM . Zaldaride maleate prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na +, Ca 2+ and K + currents in PC12 cells and inhibits nAChR .
Synonyms: CR 2039 free base; Dizolast free base
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Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma .
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Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC50 of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects .
Cat. No.: HY-106358A
CAS No.: 143330-46-5
Synonyms: CR 2039; Dizolast
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Andolast (CR 2039) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma .
Cat. No.: HY-N8092
CAS No.: 99217-64-8
Category:
Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-B1505A
CAS No.: 18833-13-1
Synonyms: Theophyllineacetic acid piperazine; Theophylline-7-acetic acid piperazine
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Acefylline (Theophyllineacetic acid) piperazine, a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline piperazine is a peptidylarginine deiminase (PAD) activator. Acefylline piperazine is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline piperazine can be used in asthma research .
Cat. No.: HY-W349178
CAS No.: 88296-61-1
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Medorinone is an inhibitor of cAMP phosphodiesterase activity. Medorinone can be used as a cardiac stimulant/vasodilator .
Cat. No.: HY-N2658
CAS No.: 23246-80-2
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Cat. No.: HY-106358R
CAS No.: 132640-22-3
Synonyms: CR 2039 free base (Standard); Dizolast free base (Standard)
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Andolast (free base) (Standard) is the analytical standard of Andolast (free base). This product is intended for research and analytical applications. Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma .
Synonyms: Theophyllineacetic acid (Standard); Theophylline-7-acetic acid (Standard)
Cat. No.: HY-P2424
CAS No.: 144396-38-3
Synonyms: CCK-J
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Cat. No.: HY-N13132
CAS No.: 132278-04-7
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Cat. No.: HY-N3324
CAS No.: 184587-72-2
Synonyms: (+)-Mangostanol
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Cat. No.: HY-N14662
CAS No.: 98890-01-8
Synonyms: 7′-Desoxygriseolic acid
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
