2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Andolast

Andolast (CR 2039) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma.

For research use only. We do not sell to patients.

Andolast Chemical Structure

Andolast Chemical Structure

CAS No. : 143330-46-5

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Description

Andolast (CR 2039) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma[1].

In Vivo

Andolast (CR 2039) (i.v. or i.m.) inhibits rat passive cutaneous anaphylaxis (PCA) with an ED50 of 0.1 mg/kg[1].
CR 2039 (10-100 mg/kg; i.v. or i.m.) inhibits the microvascular permeability changes in a model of allergic conjunctivitis in sensitized guinea-pigs[1].
CR 2039 (0-1000 μM; i.v.) inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC50 value of 50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Hartley guinea-pigs (300-500 g) [1]
Dosage: 10-100 mg/kg
Administration: I.M; I.V.
Result: Showed dose-related significant protection against lgE-dependent bronchial anaphylaxis induced by aerosolized antigen in anesthetized guinea-pigs.
Delayed dose dependently the onset of bronchoconstriction induced by aerosolized antigen.
Molecular Weight

379.29

Formula

C15H11N9Na2O
CAS No.
SMILES

O=C(C1=CC=C(C2=NN=NN2)C=C1)NC3=CC=C(C4=NN=NN4)C=C3.[Na].[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 11.36 mg/mL (29.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6365 mL 13.1825 mL 26.3650 mL
5 mM 0.5273 mL 2.6365 mL 5.2730 mL
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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6365 mL 13.1825 mL 26.3650 mL 65.9126 mL
5 mM 0.5273 mL 2.6365 mL 5.2730 mL 13.1825 mL
10 mM 0.2637 mL 1.3183 mL 2.6365 mL 6.5913 mL
15 mM 0.1758 mL 0.8788 mL 1.7577 mL 4.3942 mL
20 mM 0.1318 mL 0.6591 mL 1.3183 mL 3.2956 mL
25 mM 0.1055 mL 0.5273 mL 1.0546 mL 2.6365 mL
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Andolast Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Andolast143330-46-5CR 2039 DizolastCR2039CR-2039Phosphodiesterase (PDE)anti-allergiccAMP-phosphodiesteraseasthmapassive cutaneous anaphylaxisInhibitorinhibitorinhibit

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