652-37-9
652-37-9
Chemical Structure
Acefylline
Synonym(s): Theophyllineacetic acid; Theophylline-7-acetic acid
- CAS No.: 652-37-9
- Formula:C9H10N4O4
- Molecular Weight:238.20
IUPAC Name: 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid
InChIKey: HCYFGRCYSCXKNQ-UHFFFAOYSA-N
SMILES: O=C(O)CN1C=NC(N(C)C(N2C)=O)=C1C2=O
Biological Activity: Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Acefylline | 99.52% | Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research. | ||||||||||||||||||||
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Acefylline (GMP) | Acefylline (Theophyllineacetic acid) (GMP), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline (GMP) is a peptidylarginine deiminase (PAD) activator. Acefylline (GMP) is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline (GMP) can be used in asthma research. | |||||||||||||||||||||
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Acefylline (Standard) | ≥98% | Acefylline (Theophyllineacetic acid) (Standard) is the analytical standard of Acefylline (HY-B1505). This product is intended for research and analytical applications. Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research. | ||||||||||||||||||||
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Etamiphyllin | 99.33% | Etamiphyllin (Etamiphylline) is a respiratory and cardiac stimulant. Etamiphyllin camsylate relaxes bronchial and bronchiolar smooth muscle to open airways, and increases cardiac output without elevating heart rate. The level of Etamiphyllin camsylate decreases in mice with ulcerative colitis, and it is positively correlated with *Bifidobacterium* and *Faecalibacterium*. Etamiphyllin camsylate can be applied to research related to chronic obstructive pulmonary disease, respiratory failure and ulcerative colitis. | ||||||||||||||||||||
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Lomifylline | 99.67% | Lomifylline is a derivative of Xanthine (HY-W017389). Lomifylline can be used in research of sepsis and septic or endotoxic shock, when combined with an antibody to TNF or a TNF binding fragment. | ||||||||||||||||||||
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Nestifylline | Nestifylline is a biochemical reagent. Nestifylline can be used to study respiratory diseases such as bronchospasm. | |||||||||||||||||||||
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Xanthinol | Xanthinol is a vasodilator that can be used for the study of peripheral and cerebral vascular disorders. | |||||||||||||||||||||
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Isbufylline | Isbufylline is a Phosphodiesterase inhibitor. Isbufylline is orally available. Isbufylline can be used in the research of respiratory diseases and inflammation such as asthma and pneumonia. | |||||||||||||||||||||
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Doxofylline (Standard) | ≥98% | Doxofylline (Standard) is the analytical standard of Doxofylline. This product is intended for research and analytical applications. Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm. | ||||||||||||||||||||
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Diphylline (Standard) | 99.22% | Diphylline (Standard) is the analytical standard of Diphylline. This product is intended for research and analytical applications. Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema. | ||||||||||||||||||||
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Etofylline (Standard) | 99.93% | Etofylline (Standard) is the analytical standard of Etofylline. This product is intended for research and analytical applications. Etofylline (7-(β-Hydroxyethyl)theophylline) is a N-7-substituted derivative of Theophylline. Etofylline is a bronchodilator which can be used for the research of asthma. Etofylline is also an anticholesteremic and reduces total cholesterol level in the blood. | ||||||||||||||||||||
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Proxyphylline | 99.93% | Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator. | ||||||||||||||||||||
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1-(3-Carboxypropyl)-3,7-dimethylxanthine | 1-(3-Carboxypropyl)-3,7-dimethylxanthine is the major circulating oxidative carboxylation metabolite of Pentoxifylline (HY-B0715). 1-(3-Carboxypropyl)-3,7-dimethylxanthine protects fibrosarcoma cells against the cytotoxic effect of TNF-α. | |||||||||||||||||||||
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References
- [1]. Ferretti C, et al. Inhibitory effect of theophylline, theophylline-7-acetic acid, ambroxol and ambroxol-theophylline-7-acetate on rat lung cAMP phosphodiesterase isoenzymes. Int J Tissue React. 1992;14(1):31-6. [Content Brief]
- [2]. Méchin MC, et, al. Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis. J Dermatol Sci. 2016 Feb;81(2):101-6. [Content Brief]
- [3]. Tsvetkova B, Tencheva J, Peikov P. Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. Acta Pharm. 2006 Jun;56(2):251-7. PMID: 16613730. [Content Brief]
