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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
55 Results for "
casein kinase 1 delta
" in MedChemExpress (MCE) Product Catalog:
Products (55)
55 Results for "casein kinase 1 delta" in MCE Product Catalog:
5
5 Cited Publications
Synonyms: TGR-1202; RP5264
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Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach .
5
5 Cited Publications
Synonyms: TGR-1202 hydrochloride; RP5264 hydrochloride
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Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach .
2
2 Cited Publications
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PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM).
2
2 Cited Publications
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IWP-4 is a Wnt inhibitor with an IC50 of 25 nM. IWP-4 specifically inhibits casein kinase 1δ/ε (CK1δ/ε), with an IC50 of 1.06 μM against wild-type CK1δ, 1.02 μM against the CK1δ kinase domain, and 7.07 μM against CK1ε; it shows enhanced inhibitory activity against the M82F CK1δ mutant (IC50 = 0.14 μM). IWP-4 is applicable to research related to cancer, Alzheimer's disease (AD), and heart failure .
1
1 Cited Publications
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CK1-IN-1 (Compound 1c) is a casein kinase 1 (CK1) inhibitor with IC50 values of 15 nM and 16 nM for CK1δ and CK1ε, respectively. CK1-IN-1 inhibits p38α MAPK with an IC50 of 73 nM. CK1-IN-1 can be used to study cardiomyogenesis .
1
1 Cited Publications
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Epiblastin A is an ATP competitive casein kinase 1 (CK1) inhibitor with IC50s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1 .
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Casein kinase 1δ-IN-3 (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M .
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AMG-548, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) . AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε .
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AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) . AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε .
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Casein kinase 1δ-IN-1 is an inhibitor of casein kinase 1δ (CK1δ). Casein kinase 1δ-IN-1 can be used for the research of neurodegenerative diseases such as tauopathies .
Cat. No.: HY-148233S
CAS No.: 2765264-50-2
Cat. No.: HY-153904
CAS No.: 1579991-10-8
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Casein kinase 1δ-IN-5 is a potent and selective protein kinase CK-1δ inhibitor with an IC50 of 47 nM. Casein kinase 1δ-IN-5 shows neuroprotective and anti-inflammatory properties both in vitro. Casein kinase 1δ-IN-5 has the potential for neurodegenerative diseases research.
Cat. No.: HY-169573
CAS No.: 851467-69-1
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Casein kinase 1δ-IN-16 (compound 506) is a casein kinase 1δ (CK1δ) inhibitor. Casein kinase 1δ-IN-16 can be utilized in neurodegenerative disorders research .
Cat. No.: HY-169574
CAS No.: 450394-66-8
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Casein kinase 1δ-IN-17 (compound 753) is a casein kinase 1δ (CK1δ) inhibitor. Casein kinase 1δ-IN-17 can be utilized in neurodegenerative disorders research .
Cat. No.: HY-169577
CAS No.: 522626-08-0
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Casein kinase 1δ-IN-18 (compound 660) is a casein kinase 1δ (CK1δ) inhibitor. Casein kinase 1δ-IN-18 can be utilized in neurodegenerative disorders research .
Cat. No.: HY-169677
CAS No.: 849012-74-4
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Casein kinase 1δ-IN-30 (Compound 581) is a Casein kinase 1δ (CK1δ) inhibitor. Casein kinase 1δ-IN-30 can be used in the research of neurodegenerative diseases .
Cat. No.: HY-156913
CAS No.: 345616-08-2
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Casein kinase 1δ-IN-13 (compound 401) is a Casein kinase 1δ inhibitor. Casein kinase 1δ-IN-13 can be used in neurodegenerative disease research .
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Casein kinase 1δ-IN-4 (compound 567) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-4 has the potential for the research of Alzheimer's disease .
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Casein kinase 1δ-IN-7 (compound 497) is a Casein kinase 1δ inhibitor. Casein kinase 1δ-IN-7 can be used in the study of neurodegenerative disorders such as Alzheimer's disease .
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Casein kinase 1δ-IN-8 (compound 494) is an inhibitor of Casein kinase 1δ, Casein kinase 1δ-IN-8 can be used in the study of neurodegenerative disorders such as Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
