16470-02-3
Chemical Structure
Epiblastin A
- CAS No.: 16470-02-3
- Formula:C12H10ClN7
- Molecular Weight:287.71
IUPAC Name: 6-(3-chlorophenyl)pteridine-2,4,7-triamine
InChIKey: ZWNKKZSRANLVEW-UHFFFAOYSA-N
SMILES: NC1=NC(N)=C2N=C(C(N)=NC2=N1)C3=CC=CC(Cl)=C3
Biological Activity: Epiblastin A is an ATP-competitive casein kinase 1 (CK1) inhibitor that inhibits CK1α, CK1δ, and CK1ε. Epiblastin A inhibits the kinase activity of STK10, BRSK1, EEF2K, EGFR, MKNK2, and RIPK2. Epiblastin A inhibits Ki-67 expression, induces Oct4-GFP expression, and enhances the conversion of mouse epiblast stem cells to embryonic stem cells. Epiblastin A selectively reduces the cell viability of colorectal cancer cell lines HCT116, HT29, and DLD1. Epiblastin A can be used in colorectal cancer-related research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Epiblastin A | 99.44% | Epiblastin A is an ATP-competitive casein kinase 1 (CK1) inhibitor that inhibits CK1α, CK1δ, and CK1ε. Epiblastin A inhibits the kinase activity of STK10, BRSK1, EEF2K, EGFR, MKNK2, and RIPK2. Epiblastin A inhibits Ki-67 expression, induces Oct4-GFP expression, and enhances the conversion of mouse epiblast stem cells to embryonic stem cells. Epiblastin A selectively reduces the cell viability of colorectal cancer cell lines HCT116, HT29, and DLD1. Epiblastin A can be used in colorectal cancer-related research. | ||||||||||||||||||||
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References
- [1]. Ren F, et al. CK1α-targeting inhibits primary and metastatic colorectal cancer in vitro, ex vivo, in cell-line-derived and patient-derived tumor xenograft mice models. Transl Cancer Res. 2020 Mar;9(3):1903-1913.
- [2]. Ursu A, et al. Small-molecule phenotypic screening with stem cells. Nat Chem Biol. 2017 Jun;13:560-563.
- [3]. Ursu A, et al. Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell chemical biology. 2016 Apr 21;23(4):494-507. [Content Brief]
