BRSK1
BRSK1, also named SAD-B, is a brain-specific serine/threonine kinase of the AMPK-related family, activated when LKB1 phosphorylates its activation-loop threonine. BRSK1 phosphorylates tau at serine 262 and 356, priming sites that detach tau from microtubules and relevant to Alzheimer disease pathology. It also orchestrates neuronal polarity: mouse mutants lacking both mammalian BRSK kinases fail to specify axons, while BRSK-dependent phosphorylation of microtubule-associated proteins organizes the developing cytoskeleton, and studies in Caenorhabditis elegans established the ancestral role of SAD kinases in establishing neuronal polarity and presynaptic differentiation. These functions make BRSK1 a key link between metabolic signaling and neural circuit assembly.
-
BRSK1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
