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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
chemical crosslinking
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "chemical crosslinking" in MCE Product Catalog:
9
9 Cited Publications
Synonyms: HOSu; 1-Hydroxy-2,5-pyrrolidinedione
1
1 Cited Publications
Cat. No.: HY-48999A
CAS No.: 3033987-42-4
FSK hydrochloride is fluorosulfonyloxybenzoyl-L-lysine, which features a long, flexible aryl fluorosulfate-containing side chain that can reach protein sites inaccessible to covalent conjugation. FSK hydrochloride modifies nanomolecules to target epidermal growth factor receptor (EGFR), resulting in irreversibly bound covalent interactions. Through genetically encoded chemical crosslinking, FSK hydrochloride captures unknown enzyme-substrate interactions in living cells, targets residues other than Cys, and mediates crosslinking at the binding periphery. FSK hydrochloride enables the construction of a bioreactive SuFEx system for generating covalent bonds in various proteins both in vitro and in vivo .
Cat. No.: HY-W115727B
CAS No.: 9003-05-8
Synonyms: PAM,Anion,Mw 18 million
Cat. No.: HY-W041994
CAS No.: 80307-12-6
Research Areas:
GMBS is a heterobifunctional crosslinker targeting primary amines and sulfhydryl groups. GMBS can be used for chemical crosslinking of proteins and crosslinking mass spectrometry (CXMS) to study protein folding and map interfaces between interacting proteins .
Cat. No.: HY-W115727E
CAS No.: 9003-05-8
Synonyms: PAM,average Mn 150000
Target:
Research Areas:
Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].
Cat. No.: HY-W115727A
CAS No.: 9003-05-8
Synonyms: PAM,Anion,Mw 14-16 million
Cat. No.: HY-107783
CAS No.: 185332-92-7
Target:
Research Areas:
Sulfo-GMBS is a crosslinker widely used in chemical modification and coupling reactions of proteins and peptides. Among amine-thiol crosslinkers, Sulfo-GMBS generates the largest number of crosslinks and covers most of the crosslinks identified by AMAS and GMBS .
Cat. No.: HY-W250309
CAS No.: 7575-23-7
Cat. No.: HY-W092039
CAS No.: 1450754-38-7
Target:
Research Areas:
3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine is a diazirine-containing crosslinking agent, and it is used in chemical probe synthesis .
Cat. No.: HY-W115727D
CAS No.: 9003-05-8
Synonyms: PAM,average Mn 40000
Cat. No.: HY-W115727C
CAS No.: 9003-05-8
Synonyms: Acrylamide polymer,Nonionic,Mw 5-6 million
Cat. No.: HY-W006886
CAS No.: 945212-26-0
Target:
Research Areas:
Cat. No.: HY-W391506
CAS No.: 9011-14-7
Synonyms: Poly(methyl methacrylate), beads; PMMA
Research Areas:
Poly (methyl methacrylate) (Poly(methyl methacrylate), beads; PMMA) is an amorphous glassy acrylic thermoplastic polymer belonging to the acrylate family, synthesized from methyl methacrylate monomers. Poly (methyl methacrylate) drives biochemical processes including free volume expansion induced by inelastic deformation, yield stress and strain softening regulated by physical aging, acid hydrolysis to polymethacrylic acid, multi-stage combustion, oxygen-dependent thermal decomposition, primary amine-mediated polypentanimide formation, and grafting/crosslinking-based copolymer and composite formation. Poly (methyl methacrylate) exhibits histocompatibility, low toxicity, low inflammatory potential, and fracture resistance; it can form functional blends and composites for biomedical and dental applications; it also allows performance-enhancing chemical and mechanical modifications. Poly (methyl methacrylate) is applicable to studies related to cranial repair .
Cat. No.: HY-W341499
CAS No.: 4494-26-2
Target:
Research Areas:
5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein .
Research Areas:
Hexamethoxymethylmelamine (Hexakis(methoxymethyl)melamine; HMMM) is a type of multifunctional melamine-formaldehyde crosslinker. Under acid-catalyzed conditions, Hexamethoxymethylmelamine enables chemical crosslinking between hydroxyl-functionalized polymers and hydroxyl groups in coating systems via methoxy-hydroxyl reactions, forming an interconnected network structure. Hexamethoxymethylmelamine can be used in organic synthesis-related research, such as thermosetting coatings .
Cat. No.: HY-D1546
CAS No.: 139554-72-6
Cat. No.: HY-W142308
CAS No.: 68223-93-8
Cat. No.: HY-129655
CAS No.: 92921-26-1
Target:
Research Areas:
Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules .
Cat. No.: HY-W127344
CAS No.: 112-77-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
