5-Formyl-2'-deoxyuridine
Based on 1 Customer Validation
5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein.
For research use only. We do not sell to patients.
- Purity: 99.64%
- CAS No.: 4494-26-2
- Formula: C10H12N2O6
- Molecular Weight:256.21
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HFF | CC50 |
>300 μM
Compound: 1b
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Cytotoxicity against HFF cell line by neutral red toxicity assay
Cytotoxicity against HFF cell line by neutral red toxicity assay
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[PMID: 16722657] |
| HFF | EC50 |
>300 μM
Compound: 1b
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Antiviral activity against cowpox virus Brighton measured as cytopathogenicity in HFF cells
Antiviral activity against cowpox virus Brighton measured as cytopathogenicity in HFF cells
|
[PMID: 16722657] |
| HFF | EC50 |
>300 μM
Compound: 1b
|
Antiviral activity against vaccinia virus Copenhagen measured as cytopathogenicity in HFF cells
Antiviral activity against vaccinia virus Copenhagen measured as cytopathogenicity in HFF cells
|
[PMID: 16722657] |
Chemical Information
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CAS No. 4494-26-2
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Appearance Solid
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Molecular Weight 256.21
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Formula C10H12N2O6
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Color White to off-white
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SMILES
OC[C@@H]1[C@@H](O)C[C@H](N2C=C(C=O)C(NC2=O)=O)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 200 mg/mL (780.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9030 mL | 19.5152 mL | 39.0305 mL | 97.5762 mL |
| 5 mM | 0.7806 mL | 3.9030 mL | 7.8061 mL | 19.5152 mL | |
| 10 mM | 0.3903 mL | 1.9515 mL | 3.9030 mL | 9.7576 mL | |
| 15 mM | 0.2602 mL | 1.3010 mL | 2.6020 mL | 6.5051 mL | |
| 20 mM | 0.1952 mL | 0.9758 mL | 1.9515 mL | 4.8788 mL | |
| 25 mM | 0.1561 mL | 0.7806 mL | 1.5612 mL | 3.9030 mL | |
| 30 mM | 0.1301 mL | 0.6505 mL | 1.3010 mL | 3.2525 mL | |
| 40 mM | 0.0976 mL | 0.4879 mL | 0.9758 mL | 2.4394 mL | |
| 50 mM | 0.0781 mL | 0.3903 mL | 0.7806 mL | 1.9515 mL | |
| 60 mM | 0.0651 mL | 0.3253 mL | 0.6505 mL | 1.6263 mL | |
| 80 mM | 0.0488 mL | 0.2439 mL | 0.4879 mL | 1.2197 mL | |
| 100 mM | 0.0390 mL | 0.1952 mL | 0.3903 mL | 0.9758 mL |
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