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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
chymotrypsin substrate
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "chymotrypsin substrate" in MCE Product Catalog:
26
26 Publications Verification
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Cardiovascular Disease Neurological Disease Endocrinology Cancer
IU1 is a selective, reversible USP14 inhibitor with an IC50 of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .
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2 Cited Publications
Synonyms: Suc-Ala-Ala-Pro-Phe-AMC
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1 Cited Publications
Cat. No.: HY-P4476
CAS No.: 72682-69-0
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Cat. No.: HY-148073
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Cat. No.: HY-P4581
CAS No.: 128802-78-8
Synonyms: Suc-ALPF-pNA
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Proteasome Apoptosis Autophagy Caspase Bcl-2 Family NF-κB PARP
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PI-1840 is a potent and selective chymotrypsin-like (CT-L) inhibitor for with an IC50 value of 27 nM. PI-1840 inhibits cell proliferation and arrest cell cycle at G2/M phase. PI-1840 induces apoptosis and induces autophagy. PI-1840 induces the accumulation of proteasome substrates p27, Bax, and IκB-α .
Cat. No.: HY-P5376
CAS No.: 82564-18-9
Synonyms: S-2586
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Cat. No.: HY-129867
CAS No.: 152015-61-7
Synonyms: Z-LLL-AMC
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Cat. No.: HY-P4516
CAS No.: 104634-10-8
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Cat. No.: HY-E70353
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Trypsin-Chymotrypsin 6:1 is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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Cat. No.: HY-P4580
CAS No.: 80651-95-2
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Cat. No.: HY-W141825
CAS No.: 20874-31-1
Cat. No.: HY-P4491
CAS No.: 1926163-44-1
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Cat. No.: HY-137186
CAS No.: 68982-90-1
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Cat. No.: HY-E70352
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Trypsin-Chymotrypsin 1:250 is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
Cat. No.: HY-148415
CAS No.: 34336-99-7
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Ac-Phe-Gly-pNA is the chymotrypsin specific substrate .
Cat. No.: HY-P4346
CAS No.: 201853-55-6
Cat. No.: HY-W283888
CAS No.: 133950-77-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
