128802-78-8
Chemical Structure
Suc-Ala-Leu-Pro-Phe-pNA
Synonym(s): Suc-ALPF-pNA
- CAS No.: 128802-78-8
- Formula:C33H42N6O9
- Molecular Weight:666.72
InChIKey: RGNLNVHDRHWWDQ-ZYEMSUIVSA-N
SMILES: [O-][N+](C(C=C1)=CC=C1NC([C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@H](CC(C)C)NC([C@H](C)NC(CCC(O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) is a synthetic polypeptide substrate that targets FK506-binding protein (FKBP). Suc-Ala-Leu-Pro-Phe-pNA can be used to determine peptidyl-prolyl cis-trans isomerase activity via the chymotrypsin-coupled assay. Suc-Ala-Leu-Pro-Phe-pNA serves as a substrate for human FK506-binding protein hFKBP-12 in the chymotrypsin-FKBP coupled PPIase assay. Suc-Ala-Leu-Pro-Phe-pNA is applicable for the detection and research of PPIase activity[1][2].
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Suc-Ala-Leu-Pro-Phe-pNA | 99.41% | Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) is a synthetic polypeptide substrate that targets FK506-binding protein (FKBP). Suc-Ala-Leu-Pro-Phe-pNA can be used to determine peptidyl-prolyl cis-trans isomerase activity via the chymotrypsin-coupled assay. Suc-Ala-Leu-Pro-Phe-pNA serves as a substrate for human FK506-binding protein hFKBP-12 in the chymotrypsin-FKBP coupled PPIase assay. Suc-Ala-Leu-Pro-Phe-pNA is applicable for the detection and research of PPIase activity. | ||||||||||||||||||||
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- [1]. Dimou M, et al. Transcriptional and biochemical characterization of two Azotobacter vinelandii FKBP family members. J Microbiol. 2011;49(4):635-640. [Content Brief]
- [2]. Demange L, et al. Synthesis and Evaluation of Glyψ(PO₂R-N)Pro-Containing Pseudopeptides as Novel Inhibitors of the Human Cyclophilin hCyp-18. J Med Chem. 2002 Jul 25;45(18):3928-3933.
Keywords
