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co-transcriptional capping

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-185611
    A(5')ppp(5')(2'-OMeA)pG tetraammonium

    		Nucleoside Antimetabolite/Analog Others
    A(5')ppp(5')(2'-OMeA)pG tetraammonium is an anti-reverse Cap 1 reagent, used for co-transcriptional capping of in vitro transcribed mRNA. A(5')ppp(5')(2'-OMeA)pG tetraammonium does not compete with GTP to initiate transcription in the reaction system, thus effectively avoiding the reduction of the proportion of capped mRNA while maintaining a high GTP concentration. A(5')ppp(5')(2'-OMeA)pG tetraammonium can be used for efficient synthesis of high-quality in vitro transcribed mRNA .
    A(5')ppp(5')(2'-OMeA)pG tetraammonium
  • HY-E70405
    Guanylyltransferase

    		Others Others
    Guanylyltransferase (GTase) plays a central role in the three-step catalytic process of adding an m7GpppN cap cotranscriptionally to nascent mRNA (pre-mRNAs) .
    Guanylyltransferase
  • HY-145973B
    3'OMe-m7GpppAmpG Tris

    		Nucleoside Antimetabolite/Analog SARS-CoV Infection
    3'OMe-m7GpppAmpG (Tris) is a trinucleotide Cap1 analog with the structure m7 (3'OMeG)(5') ppp (5')(2'OMeA) pG, and also functions as a cis-acting ligase ribozyme inhibitor. 3'OMe-m7GpppAmpG (Tris) effectively reduces free 5'-triphosphate groups on RNA transcripts, thereby enabling efficient co-transcriptional capping of in vitro transcribed mRNA. 3'OMe-m7GpppAmpG (Tris) is not only widely used in the preparation of modified mRNA including trivalent influenza vaccine candidates, but also applicable to studies related to SARS-CoV-2 infection and other relevant research .
    3'OMe-m7GpppAmpG Tris

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