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Results for "

coumarin compound

" in MedChemExpress (MCE) Product Catalog:

70

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1

Screening Libraries

1

Fluorescent Dyes

2

Biochemical Assay Reagents

47

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0573
    Umbelliferone
    5 Publications Verification

    7-Hydroxycoumarin; Hydrangin; NSC 19790

    		 Apoptosis Fluorescent Dye Neurological Disease Inflammation/Immunology Cancer
    Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .
    Umbelliferone
  • HY-N2488
    Demethylsuberosin
    4 Publications Verification

    7-Demethylsuberosin

    		 Calcium Channel NO Synthase Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound found in Angelica gigas Nakai. Demethylsuberosin exerts antihypertensive effects by inhibiting the L-type CaV1.2 channel. Demethylsuberosin has antioxidant and anti-inflammatory activities. Demethylsuberosin also exhibits neuroprotective activities against glutamate-induced toxicity in primary cultured rat cortical cells .
    Demethylsuberosin
  • HY-N6856
    4-Hydroxycoumarin

    		Bacterial Endogenous Metabolite Infection Cancer
    4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
    4-Hydroxycoumarin
  • HY-W027968
    Coumarin-3-carboxylic Acid
    2 Publications Verification

    2-Oxochromene-3-carboxylic acid

    		 Fluorescent Dye Cancer
    Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line .
    Coumarin-3-carboxylic Acid
  • HY-Y1298
    Methyl acetylacetate
    1 Publications Verification

    Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate

    		 Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives. Methyl acetoacetate can be used in the study of inflammatory diseases .
    Methyl acetylacetate
  • HY-W506116
    Ostruthin

    Ostruthine

    		 Bacterial DNA/RNA Synthesis Cardiovascular Disease Infection
    Ostruthin is a natural coumarin compound with bacterial and antimycobacterial activities . Ostruthin inhibits the growth of mycobacteria and Staphylococcus aureus. Ostruthin suppresses vascular smooth muscle cell proliferation as well as de novo cellular DNA synthesis. Ostruthin is applicable to research related to mycobacterial infections and cardiovascular and cerebrovascular diseases .
    Ostruthin
  • HY-N0081
    (±)-Praeruptorin A

    		Calcium Channel NF-κB Interleukin Related Cardiovascular Disease Inflammation/Immunology
    (±)-Praeruptorin A, a coumarin compound, is the main bioactive component in Peucedani Radix. As a calcium channel blocker, (±)-Praeruptorin A exhibits great antihypertensive effects. In addition, (±)-Praeruptorin A also has the effects of relaxing vascular smooth muscle, inhibiting airway inflammation and airway hyperresponsiveness. (±)-Praeruptorin A can be used for the research of allergic asthma, hypertension and other diseases .
    (±)-Praeruptorin A
  • HY-D0046
    Coumarin-6-sulfonyl chloride

    2-Oxo-2H-chromene-6-sulfonyl chloride

    		 Biochemical Assay Reagents Others
    Coumarin-6-sulfonyl chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Coumarin-6-sulfonyl chloride
  • HY-109714
    3,4-Benzocoumarin

    		Drug Derivative Inflammation/Immunology
    3,4-Benzocoumarin is a kind of the expanded structure of coumarin derivatives.Coumarin is a chemical compound in the benzopyrone chemical class that can be found in many natural species. Coumarins possess variety of biological activities and unique photophysical properties . 3,4-Benzocoumarin, a AOH‐like compound , has the sensibility of the antibody with an IC50 of 919.2 ng/mL .
    3,4-Benzocoumarin
  • HY-135646
    Eleutheroside B1

    		Influenza Virus Infection Inflammation/Immunology
    Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities .
    Eleutheroside B1
  • HY-N2558
    Murrayone

    		Others Cancer
    Murrayone, a coumarin-containing compound extracted from M. paniculata, is the most bioactive substance in this species and is a cancer metastasis chemopreventive agent based on its unique pharmacological properties .
    Murrayone
  • HY-76779
    4-(Chloromethyl)-7-hydroxycoumarin

    		Drug Derivative Cancer
    4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .
    4-(Chloromethyl)-7-hydroxycoumarin
  • HY-N0573R
    Umbelliferone (Standard)

    7-Hydroxycoumarin (Standard); Hydrangin (Standard); NSC 19790 (Standard)

    		 Reference Standards Apoptosis Fluorescent Dye Neurological Disease Inflammation/Immunology Cancer
    Umbelliferone (Standard) (7-Hydroxycoumarin (Standard)) is the analytical standard of Umbelliferone (HY-N0573). This product is intended for research and analytical applications. Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats.
    Umbelliferone (Standard)
  • HY-N0573S
    Umbelliferone-d5

    7-Hydroxycoumarin-d5; Hydrangin-d5; NSC 19790-d5

    		 Isotope-Labeled Compounds Apoptosis Fluorescent Dye Neurological Disease Inflammation/Immunology Cancer
    Umbelliferone-d5 (7-Hydroxycoumarin-d5) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .
    Umbelliferone-d5
  • HY-N2623
    Alloimperatorin
    1 Publications Verification

    Prangenidin

    		 Others Cancer
    Alloimperatorin (Prangenidin), a coumarin compound, is extracted from Angelica dahurica. Alloimperatorin (Prangenidin) has antitumor activity .
    Alloimperatorin
  • HY-N6856R
    4-Hydroxycoumarin (Standard)

    		Reference Standards Bacterial Endogenous Metabolite Infection Cancer
    4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin. This product is intended for research and analytical applications. 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
    4-Hydroxycoumarin (Standard)
  • HY-D0066
    7-Diethylaminocoumarin-3-carbohydrazide

    DCCH

    		 Fluorescent Dye Others
    7-Diethylaminocoumarin-3-carbohydrazide is a coumarin. 7-Diethylaminocoumarin-3-carbohydrazide can be used to detect sugar chains and quantify biological carbonyl compounds .
    7-Diethylaminocoumarin-3-carbohydrazide
  • HY-128105
    1,2-Dihydroxynaphthalene

    		Bacterial Others
    1,2-Dihydroxynaphthalene is an intermediate isolated from the metabolism of naphthalene and has been shown to be a precursor to the formation of naphthoquinones. 1,2-Dihydroxynaphthalene can be further metabolized by some bacteria (such as Pseudomonas) to compounds such as coumarins and salicylic acid .
    1,2-Dihydroxynaphthalene
  • HY-N9531
    3'-Hydroxyxanthyletin

    		Bacterial Infection
    3'-Hydroxyxanthyletin is a coumarin compound with antimycobacterial activities .
    3'-Hydroxyxanthyletin
  • HY-W094665
    7-(Diethylamino)-4-(hydroxymethyl)coumarin

    		Biochemical Assay Reagents Others
    7-(Diethylamino)-4-(hydroxymethyl)coumarin (compound 10) is an organic compound that can be used as a photosensitizer in organic synthesis .
    7-(Diethylamino)-4-(hydroxymethyl)coumarin
  • HY-N10978
    (-)-8-Methoxyobliquin

    		Others Others
    (-)-8-Methoxyobliquin is a coumarin compound that can be isolated from the aerial parts ofH. heterophyllus .
    (-)-8-Methoxyobliquin
  • HY-N6658
    6-Hydroxy-4-methylcoumarin

    		Drug Metabolite Cancer
    6-Hydroxy-4-methylcoumarin (compound 9) is a coumarins secondary metabolites and has anticancer activity .
    6-Hydroxy-4-methylcoumarin
  • HY-N10015
    7-Methoxy-4-methyl-coumarin-8-ol

    		Others Others
    7-Methoxy-4-methyl-coumarin-8-ol (compound 31) is a compound isolated from sour orange (Citrus aurantium) .
    7-Methoxy-4-methyl-coumarin-8-ol
  • HY-179212
    (±)-Coladonin

    		Drug Derivative Fungal Infection
    (±)-Coladonin (Compound (±)-12), Coumarin (HY-N0709) derivative, is an antifungal agent. (±)-Coladonin exhibits potent inhibitory effect on the plant pathogenic fungus Botrytis cinerea. (±)-Coladonin is mainly used for the research on the prevention and control of gray mold disease in crops .
    (±)-Coladonin
  • HY-177798
    AChE-IN-98

    		Cholinesterase (ChE) Neurological Disease
    AChE-IN-98 (Compound 26) is an AChE inhitibor, with an IC50 value of 7.3 μM for ee AChE. AChE-IN-98 is also a Coumarin (HY-N0709) derivative. AChE-IN-98 can be used in the research of Alzheimer's disease .
    AChE-IN-98
  • HY-149958
    Antileishmanial agent-17

    		Parasite Infection
    Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
    Antileishmanial agent-17
  • HY-N4280
    7,8-Dimethoxycoumarin
    1 Publications Verification

    		 Na+/K+ ATPase Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related Neurological Disease Metabolic Disease Inflammation/Immunology
    7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H +/K +-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis .
    7,8-Dimethoxycoumarin
  • HY-N8632
    Qianhucoumarin A

    		Others Others
    Qianhucoumarin A is a natural coumarin compound found in the roots of Peucedanum praeruptorum Dunn .
    Qianhucoumarin A
  • HY-N10169
    Edgeworin

    		Others Others
    Edgeworin is a coumarin compound can be isolated from the root and stem of Edgeworthia .
    Edgeworin
  • HY-N10029
    Edgeworoside C

    		Others Others
    Edgeworoside C (compound 5) is a coumarin isolated from the flower buds of Edgeworthia chrysantha .
    Edgeworoside C
  • HY-N15523
    Moracin M 6-β-D-glucopyranoside

    		Others Others
    Moracin M 6-β-D-glucopyranoside is found in Morus alba. Moracin M 6-β-D-glucopyranoside is a derivative of coumarin compounds .
    Moracin M 6-β-D-glucopyranoside
  • HY-138145
    8-Acetyl-7-hydroxycoumarin

    		Fungal Bacterial Infection
    8-Acetyl-7-hydroxycoumarin is a coumarin-like compound found in Mexican patchouli (Tagetes lucida) that has anti-bacterial and anti-fungal activities .
    8-Acetyl-7-hydroxycoumarin
  • HY-N8618
    Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol

    		Others Others
    Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol was identified as one of the phenolic compounds isolated from Canadian maple syrup (MS-BuOH). It exhibited antioxidant properties along with other phenolic compounds and coumarins isolated from the syrup. These compounds showed varying degrees of antioxidant activity, with phenolic derivatives and coumarins showing superior activity, more so than lignans and flavonoids. This study marks the first time that 16 of the 23 phenolic compounds, including Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol, have been identified in maple syrup .
    Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol
  • HY-163397
    Antibacterial agent 196

    		Fungal Infection
    Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC50 of 0.46 μg/mL against Rhizoctonia solani .
    Antibacterial agent 196
  • HY-117754
    PSB-SB1202

    		Cannabinoid Receptor Neurological Disease
    PSB-SB1202 (Compound 21a) is a phenyl coumarin compound. PSB-SB1202 is a CB1/CB2 agonist with EC50 values of 56 and 14 nM, and Ki values of 32 and 49 nM, respectively .
    PSB-SB1202
  • HY-N7650
    Dihydroseselin

    		Biochemical Assay Reagents Others
    Dihydroseselin is a derivative of 7-hydroxycoumarin (HY-N0573). 7-hydroxycoumarin, a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent
    Dihydroseselin
  • HY-N12875
    Ailancoumarin E

    		Tyrosinase Others
    Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC50 of 14.21 μM .
    Ailancoumarin E
  • HY-N15662
    Coumestan

    		Drug Intermediate Infection Neurological Disease Inflammation/Immunology Cancer
    Coumestan is a secondary metabolite found in leguminous plants and can be used as drug intermediate Coumestan can be used to synthesize various coumarin compounds such as Coumestrol (HY-N2335), Glytabastan B, and Coumestan Pks13 inhibitor. Coumestans can be used for the study of anti-cancer, anti-inflammatory, anti-oxidative, antibacterial, neuroprotective and organ protective .
    Coumestan
  • HY-131799A
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium

    		Nucleoside Antimetabolite/Analog Others
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium is an amine-modified nucleotide that can be used in the synthesis of other active compounds. The coumarin-labeled derivatives of 3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium exhibit significant fluorescence changes when interacting with myosin and can mimic the function of natural ADP .
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium
  • HY-163457
    Antileishmanial agent-27

    		Aminoacyl-tRNA Synthetase Parasite Infection
    Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .
    Antileishmanial agent-27
  • HY-N0081R
    (±)-Praeruptorin A (Standard)

    		Reference Standards Calcium Channel Interleukin Related Cardiovascular Disease Inflammation/Immunology
    (±)-Praeruptorin A (Standard) is the analytical standard of (±)-Praeruptorin A (HY-N0081). This product is intended for research and analytical applications. (±)-Praeruptorin A, a coumarin compound, is the main bioactive component in Peucedani Radix. As a calcium channel blocker, (±)-Praeruptorin A exhibits great antihypertensive effects. In addition, (±)-Praeruptorin A also has the effects of relaxing vascular smooth muscle, inhibiting airway inflammation and airway hyperresponsiveness. (±)-Praeruptorin A can be used for the research of allergic asthma, hypertension and other diseases .
    (±)-Praeruptorin A (Standard)
  • HY-N3373R
    Loganetin (Standard)

    		Reference Standards Bacterial Infection
    4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin. This product is intended for research and analytical applications. 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
    Loganetin (Standard)
  • HY-158402
    Anti-inflammatory agent 84

    		Bacterial Fungal Infection Inflammation/Immunology
    Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .
    Anti-inflammatory agent 84
  • HY-W777393
    Umbelliferone-13C6

    7-Hydroxycoumarin-13C6; Hydrangin-13C6; NSC 19790-13C6

    		 Isotope-Labeled Compounds Apoptosis Fluorescent Dye Neurological Disease Inflammation/Immunology Cancer
    Umbelliferone- 13C6 (7-Hydroxycoumarin- 13C6) is the 13C-labeled Umbelliferone (HY-N0573). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .
    Umbelliferone-13C6
  • HY-N19792
    6-(3'-Methyl-1',3'-butadienyl)-5,7-dimethoxycoumarin

    		Drug Derivative Cancer
    6-(3'-Methyl-1',3'-butadienyl)-5,7-dimethoxycoumarin is a cytotoxic coumarin compound that can be isolated from the stem bark of Toddalia asiatica. 6-(3'-Methyl-1',3'-butadienyl)-5,7-dimethoxycoumarin can be used for the research of small cell lung cancer .
    6-(3'-Methyl-1',3'-butadienyl)-5,7-dimethoxycoumarin
  • HY-W110775
    Coumarin 152

    		Drug Derivative Neurological Disease
    Coumarin 152 (Compound 16) is a coumarin derivative. Coumarin 152 does not show binding affinity toward compact myelin .
    Coumarin 152
  • HY-N17572
    Angustifolin (coumarin)

    		Others Others
    Angustifolin coumarin is a coumarin compound present in the aerial parts of Ruta angustifolia .
    Angustifolin (coumarin)
  • HY-N17790
    Monoisovalerate

    		Others Others
    Monoisovalerate is a coumarin compound that can be isolated from Ammi visnaga .
    Monoisovalerate
  • HY-116931
    Kelletinin I

    		Others Others
    Kelletinin I is a coumarin compound with anti-HIV-1 activity.
    Kelletinin I
  • HY-N18259
    8-Formyllimettin

    		Drug Derivative Others
    8-Formyllimettin (Compound 25) is a coumarin compound that can be isolated from the root bark of Toddalia asiatica .
    8-Formyllimettin

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