Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
cyclin G associated kinase
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "cyclin G associated kinase" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a Ki of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK .
1
1 Cited Publications
Target:
Research Areas:
GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 also shows binding to RIPK2 .
1
1 Cited Publications
Target:
Research Areas:
LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors .
1
1 Cited Publications
Target:
Research Areas:
GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2 .
Target:
Research Areas:
BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain .
Target:
Research Areas:
BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively .
Cat. No.: HY-169789
CAS No.: 2361545-75-5
Target:
Research Areas:
PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine protein kinase 3) and GAK (cyclin G-associated kinase) with IC50 of 0.014 μM and Ki of 0.0044 μM respectively. PKN3-IN-1 is a potential tool compound to study the cell biology of PKN3 and its role in pancreatic and prostate cancer and T-cell acute lymphoblastic leukemia .
Target:
Research Areas:
BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain .
Target:
Research Areas:
GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC50 of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC50 of 1.049 μM against dengue virus (DENV) .
Cat. No.: HY-135871A
Target:
Research Areas:
BMT-124110 formic is a potent, selective AAK1 inhibitor, with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-124110 formic inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively .
Cat. No.: HY-120179A
Purity: ≥98.0%
Target:
Research Areas:
LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 hydrate shows less activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors .
Cat. No.: HY-P702862
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GAK; cyclin-G-associated kinase; cyclin G associated kinase; Auxilin-2; DNAJC26; GAK Protein; DnaJ Homolog Subfamily C Member 26; DNAJ26
Species:
Human
Source:
E. coli
Cat. No.: HY-150782
CAS No.: 2676156-05-9
UNC-CA359 is a potent epidermal growth factor receptor (EGFR) inhibitor, with an IC50 value of 18 nM. UNC-CA359 exhibits strong anti-tumor activity, can be used to Chordoma research . UNC-CA359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-P705839
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GAK; cyclin-G-associated kinase; cyclin G associated kinase; Auxilin-2; DNAJC26; GAK Protein; DnaJ Homolog Subfamily C Member 26; DNAJ26
Species:
Human
Source:
E. coli
Cat. No.: HY-P706057
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: GAK; cyclin-G-associated kinase; cyclin G associated kinase; Auxilin-2; DNAJC26; GAK Protein; DnaJ Homolog Subfamily C Member 26; DNAJ26
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-181169
Target:
Research Areas:
GAK-IN-3 is a cyclin G-associated kinase (GAK) inhibitor with an IC50 of 207 nM and a Ki of 66 nM. GAK-IN-3 inhibits kinase activity in the nanomolar range by binding to GAK’s ATP-binding site. GAK-IN-3 acts as a cytotoxic agent that reduces viability of Ewing sarcoma cells. GAK-IN-3 can be used for the research of ewing sarcoma .
Cat. No.: HY-101290AR
CAS No.: 2231664-45-0
Research Areas:
BMT-090605 (hydrochloride) (Standard) is the analytical standard of BMT-090605 (hydrochloride) (HY-101290A). This product is intended for research and analytical applications. BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain .
Cat. No.: HY-P701371
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK7; cyclin-Dependent kinase 7 (Homolog Of Xenopus MO15 Cdk-Activating kinase); cyclin Dependent kinase 7; Homolog Of Xenopus MO15 Cdk-Activating kinase; CDKN7; Serine/Threonine Protein kinase MO15; CAK1; cyclin-Dependent kinase 7 Isoform 3; MO15; Serine/Threonine Protein kinase 1; STK1; Serine/Threonine-Protein kinase 1; CAK; [RNA-Polymerase]-Subunit kinase; TFIIH Basal Transcription Factor Complex kinase Subunit; Serine/Threonine kinase Stk1; Cell Division Protein kinase 7; kinase Subunit Of CAK; cyclin-Dependent kinase 7; P39 Mo15; cyclin-Dependent kinase 7 (MO15 Homolog, Xenopus Laevis, Cdk-Activating kinase); P39MO15; CDK-Activating kinase 1; HCAK; 39 KDa Protein kinase; CCNH; CycH; cyclin H; cyclin-Dependent kinase-Activating kinase Complex Subunit; P34; CDK-Activating kinase Complex Subunit; P37; CAK Complex Subunit; MO15-associated Protein; CAK; cyclin-H; MNAT1; CAP35; MNAT1 Component Of CDK Activating kinase; P36; RNF66; P35; MAT1; Menage A Trois Homolog 1, cyclin H Assembly Factor (Xenopus Laevis); CDK-Activating kinase Assembly Factor MAT1; Menage A Trois-Like Protein 1 cyclin H Assembly Factor Isoform 2; CDK7/cyclin-H Assembly Factor; Menage A Trois-Like Protein 1 cyclin H Assembly Factor; RING Finger Protein MAT1; Menage A Trois Homolog 1, cyclin H Assembly Factor; MNAT CDK-Activating kinase Assembly Factor 1; CDK-Activating kinase Assembly Factor; MNAT1, CDK Activating kinase Assembly Factor; cyclin G1 Interacting Protein; Menage A Trois 1 (CAK Assembly Factor); cyclin-G1-Interacting Protein; RING Finger Protein 66; TFB3; Menage A Trois
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P75361
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDK7; cyclin-Dependent kinase 7 (Homolog Of Xenopus MO15 Cdk-Activating kinase); cyclin Dependent kinase 7; Homolog Of Xenopus MO15 Cdk-Activating kinase; CDKN7; Serine/Threonine Protein kinase MO15; CAK1; cyclin-Dependent kinase 7 Isoform 3; MO15; Serine/Threonine Protein kinase 1; STK1; Serine/Threonine-Protein kinase 1; CAK; [RNA-Polymerase]-Subunit kinase; TFIIH Basal Transcription Factor Complex kinase Subunit; Serine/Threonine kinase Stk1; Cell Division Protein kinase 7; kinase Subunit Of CAK; cyclin-Dependent kinase 7; P39 Mo15; cyclin-Dependent kinase 7 (MO15 Homolog, Xenopus Laevis, Cdk-Activating kinase); P39MO15; CDK-Activating kinase 1; HCAK; 39 KDa Protein kinase; CCNH; CycH; cyclin H; cyclin-Dependent kinase-Activating kinase Complex Subunit; P34; CDK-Activating kinase Complex Subunit; P37; CAK Complex Subunit; MO15-associated Protein; CAK; cyclin-H; MNAT1; CAP35; MNAT1 Component Of CDK Activating kinase; P36; RNF66; P35; MAT1; Menage A Trois Homolog 1, cyclin H Assembly Factor (Xenopus Laevis); CDK-Activating kinase Assembly Factor MAT1; Menage A Trois-Like Protein 1 cyclin H Assembly Factor Isoform 2; CDK7/cyclin-H Assembly Factor; Menage A Trois-Like Protein 1 cyclin H Assembly Factor; RING Finger Protein MAT1; Menage A Trois Homolog 1, cyclin H Assembly Factor; MNAT CDK-Activating kinase Assembly Factor 1; CDK-Activating kinase Assembly Factor; MNAT1, CDK Activating kinase Assembly Factor; cyclin G1 Interacting Protein; Menage A Trois 1 (CAK Assembly Factor); cyclin-G1-Interacting Protein; RING Finger Protein 66; TFB3; Menage A Trois
Species:
Human
Source:
Sf9 insect cells
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
