Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
cytotoxicity evaluation
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "cytotoxicity evaluation" in MCE Product Catalog:
1
Target:
Research Areas:
Propanedial (Malondialdehyde) (13.88 mM in water) is one of the final products of lipid peroxidation. Propanedial causes protein inactivation, DNA damage and cross-linking by forming stable covalent adducts with biological macromolecules, which is the main mechanism for its cytotoxicity and genotoxicity.
Propanedial production increases with the elevation of free radicals.
Propanedial is a key biomarker for evaluating the level of cellular oxidative stress [1][2][3].
Cat. No.: HY-146819
CAS No.: 2439165-37-2
Target:
Research Areas:
Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC50 values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity.
Cat. No.: HY-D0300S1
CAS No.: 1173021-13-0
Cat. No.: HY-N11988
CAS No.: 858127-39-6
Category:
Apocynaceae Lignans Phenols Polyphenols Phenylpropanoids Plants Trachelospermum jasminoides (Lindl.) Lem.
Target:
Cat. No.: HY-D0300S
CAS No.: 947601-82-3
Cat. No.: HY-N21531
CAS No.: 2841395-79-5
Target:
Trolliusditerpenoside I is a labdane-type diterpenoid glycoside identified in the flowers of Trollius chinensis Bunge. Trolliusditerpenoside I exerts weak inhibitory effects on LPS (HY-D1056)-induced NO production in RAW 264.7 macrophages, with an IC50 > 50 μM, and shows no significant cytotoxicity within the effective concentration range used for NO inhibition evaluation. Trolliusditerpenoside I can be used in studies on the structure of diterpenoid glycosides and LPS-induced inflammation-related NO production .
Cat. No.: HY-N13833
CAS No.: 2188162-94-7
Target:
Cat. No.: HY-D3181
Cat. No.: HY-D3104
CAS No.: 2767443-23-0
Target:
Research Areas:
ERNT is a fluorescent probe for monitoring endoplasmic reticulum (ER) polarity and detecting endoplasmic reticulum stress (ERS) during the progression of dynamic liver injury. ERNT functions based on a donor-π-acceptor (D-π-A) structure with an intramolecular charge transfer (ICT) effect. ERNT has multiple excitation/emission pairs: for in vitro cell imaging, the green channel has Ex/Em = 488/500-550 nm, and the red channel has Ex/Em = 488/570-620 nm; for in vivo liver imaging, Ex/Em = 520/620 nm; for solvent optical tests, Ex = 470 nm, with the maximum emission peak at 548 nm in low-polarity toluene and 668 nm in high-polarity DMSO. ERNT can evaluate the efficacy of hepatoprotective interventions by detecting changes in ER polarity, and also exhibits excellent photostability and low cytotoxicity .
Cat. No.: HY-P11590
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
