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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
deconjugation
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "deconjugation" in MCE Product Catalog:
Synonyms: 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium
Target:
Research Areas:
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .
Synonyms: ABA-GE; (S)-cis,trans-Abscisic acid glucosyl ester
Category:
other families Terpenoids Sesquiterpenes Abscisic acid Plants Phytohormone Disease Research Fields Endocrinology Agricultural Research
Target:
Synonyms: Genistein 7-O-glucuronide
Target:
Research Areas:
Genistein 7-β-D-Glucuronide (Genistein 7-O-glucuronide) is the primary phase II metabolite of Genistein (HY-14596) in human and rat hepatocytes. Genistein 7-β-D-Glucuronide undergoes distinct deconjugation in different functional assays. Genistein 7-β-D-Glucuronide is produced via hepatic microsomal glucuronidation and shows a mild age-related increase in intrinsic clearance in male F344 rats. Genistein 7-β-D-Glucuronide can be used for research on metabolism .
Cat. No.: HY-137522S
Synonyms: 3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 sodium
Cat. No.: HY-137522A
CAS No.: 117675-21-5
Synonyms: 3'-Azido-3'-deoxythymidine β-D-glucuronide
Target:
Research Areas:
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .
Cat. No.: HY-E70973
Target:
Research Areas:
β-Glucuronidase/Arylsulfatase, Helix pomatia is an enzyme with arylsulfatase activity that is isolated from Roman snails (Helix pomatia). β-Glucuronidase/Arylsulfatase, Helix pomatia exhibits broad-spectrum hydrolytic specificity towards various β-glucuronides and sulfate conjugates. β-Glucuronidase/Arylsulfatase, Helix pomatia is used for simultaneous deconjugation of drug-conjugated metabolites in urine samples .
Cat. No.: HY-W754831
Synonyms: ABA-GE-d6; (S)-cis,trans-Abscisic acid glucosyl ester-d6
Cat. No.: HY-185729
Synonyms: ADCT-401
Target:
Research Areas:
MEDI3726 (ADCT-401) is a prostate-specific membrane antigen (PSMA)-targeting antibody-drug conjugate (ADC), composed of LP Tesirine (HY-128952) and antibody J591 (HY-P991359). MEDI3726 binds PSMA’s extracellular domain, triggers endocytosis, undergoes lysosomal degradation to release a pyrrolobenzodiazepine warhead. MEDI3726 induces DNA crosslinking, DNA damage, cell death, cytotoxicity, and inhibits tumor growth in mouse xenograft models. MEDI3726 undergoes in vivo catabolism primarily via heavy-light chain dissociation, with minimal warhead deconjugation. MEDI3726 can be used for the research of metastatic castration-resistant prostate cancer and prostate cancers .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
