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dehydropeptidase-I

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By Targets:	Antibiotic (6) Bacterial (6) Neurokinin Receptor (1) Reference Standards (2)
By Research Areas:	Endocrinology (1) Infection (6) Inflammation/Immunology (1) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0166

Cilastatin Maximum Cited Publications 6 Publications Verification MK0791	Bacterial Antibiotic	Infection
Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC₅₀ of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC₅₀ of 178 μM. Cilastatin is an antibacterial adjunct .

HY-A0166A

Cilastatin sodium Maximum Cited Publications 6 Publications Verification MK0791 sodium	Bacterial Antibiotic	Infection
Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC₅₀ of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC₅₀ of 178 μM. Cilastatin sodium is an antibacterial adjunct .

HY-B1127

Betamipron N-Benzoyl-β-alanine	Antibiotic Bacterial	Infection Endocrinology
Betamipron (N-benzoyl-β-alanine) is a carbapenem β-lactam antibiotic with antibacterial activity against most Gram-positive and Gram-negative aerobic and anaerobic bacteria. Betamipron can target and inhibit renal organic anion transporters, alleviate renal injury caused by Cisplatin (HY-17394), without interfering with the biological activity of cisplatin. Betamipron is often used in combination with panipenem, which can attenuate the renal effects induced by panipenem and slightly promote the proliferation of Clostridium difficile in the cecum. Betamipron can be used in studies related to renal injury and bacterial infection .

HY-A0166S

Cilastatin-15N,d3 MK0791-¹⁵N,d₃	Bacterial Antibiotic	Infection
Cilastatin- ¹⁵N,d₃ is a ¹⁵N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC₅₀ of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC₅₀ of 178 μM. Cilastatin is an antibacterial adjunct .

HY-P3820

*[Dehydro-Pro4] Substance P (4-11)*	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Dehydro-Pro4] Substance P (4-11) is a peptide fragment of Substance P. Substance P is a peptide mainly secreted by neurons. Substance P takes part in many biological processes, including nociception, inflammation and immunity .

HY-A0166R

Cilastatin (Standard) MK0791 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Cilastatin (Standard) is the analytical standard of Cilastatin. This product is intended for research and analytical applications. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC₅₀ of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC₅₀ of 178 μM. Cilastatin is an antibacterial adjunct .

HY-A0166AR

Cilastatin sodium (Standard) MK0791 sodium (Standard)	Reference Standards Bacterial Antibiotic	Infection
Cilastatin (sodium) (Standard) is the analytical standard of Cilastatin (sodium). This product is intended for research and analytical applications. Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC50 of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC50 of 178 μM. Cilastatin sodium is an antibacterial adjunct[1][2][3].

Cat. No.	Product Name	Target	Research Area

HY-P3820

*[Dehydro-Pro4] Substance P (4-11)*	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Dehydro-Pro4] Substance P (4-11) is a peptide fragment of Substance P. Substance P is a peptide mainly secreted by neurons. Substance P takes part in many biological processes, including nociception, inflammation and immunity .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70003

	DPEP1 Protein, Human (HEK293, His) rHuDipeptidase 1/DPEP1, His; Dipeptidase 1; dehydropeptidase-I; Microsomal Dipeptidase; Renal Dipeptidase; hRDP; DPEP1; MDP; RDP	Human	HEK293
	Dipeptidase 1 (DPEP1) has multiple enzymatic functions and can hydrolyze various dipeptides, including the conversion of leukotriene D4 to leukotriene E4. It is also involved in the degradation of cysteinylbisglycine resulting from the breakdown of glutathione. DPEP1 Protein, Human (HEK293, His) is the recombinant human-derived DPEP1 protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-A0166S

Cilastatin-15N,d3
Cilastatin- ¹⁵N,d₃ is a ¹⁵N-labeled and deuterium labeled Cilastatin. Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC₅₀ of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC₅₀ of 178 μM. Cilastatin is an antibacterial adjunct .

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

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HY-P81486

	DPEP1/MDP Antibody (YA1231) DPEP1; MDP; RDP; Dipeptidase 1; dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase	IHC-P	Human
	DPEP1/MDP Antibody (YA1231) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DPEP1/MDP.

HY-P81486A

	DPEP1/MDP Antibody (YA1231)(PBS only) DPEP1; MDP; RDP; Dipeptidase 1; dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase	IHC-P	Human
	DPEP1/MDP Antibody (YA1231) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DPEP1/MDP.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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