85394-14-5
Chemical Structure
MK-789
- CAS No.: 85394-14-5
- Formula:C14H23NO3
- Molecular Weight:253.34
IUPAC Name: (E)-2-(2,2-dimethylcyclopropane-1-carboxamido)oct-2-enoic acid
InChIKey: WIESNNVNXBYTFK-DHZHZOJOSA-N
SMILES: O=C(/C(NC(C1CC1(C)C)=O)=C\CCCCC)O
Biological Activity: MK-789 is a competitive reversible inhibitor of dehydropeptidase I (DHP-I). MK-789 competitively blocks the entry of N-formimidoylthienamycin into proximal tubular cells, thereby inhibiting its renal metabolism. MK-789 shifts the renal excretion pathway of N-formimidoylthienamycin to glomerular filtration only, increasing its urinary recovery rate and renal clearance. MK-789 is applicable to studies on renal metabolism and pharmacokinetics[1].
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MK-789 | MK-789 is a competitive reversible inhibitor of dehydropeptidase I (DHP-I). MK-789 competitively blocks the entry of N-formimidoylthienamycin into proximal tubular cells, thereby inhibiting its renal metabolism. MK-789 shifts the renal excretion pathway of N-formimidoylthienamycin to glomerular filtration only, increasing its urinary recovery rate and renal clearance. MK-789 is applicable to studies on renal metabolism and pharmacokinetics. | |||||||||||||||||||||
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Keywords
