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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
dipeptidyl peptidase 1
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "dipeptidyl peptidase 1" in MCE Product Catalog:
9
9 Cited Publications
Synonyms: AZD7986; INS 1007
Target:
Research Areas:
Brensocatib (AZD7986) is an oral dipeptidyl peptidase 1 (DPP1) inhibitor with pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively .
Cat. No.: HY-12733
CAS No.: 1254318-44-9
Target:
Research Areas:
AZD5248 is an orally active, selective dipeptidyl peptidase 1 (cathepsin C) inhibitor, with IC50 values of 1 nM and 17 nM against human CatC, 44 nM against human DPP1, and 67 nM against rat DPP1. It exhibits low clearance and high bioavailability in animal models. AZD5248 forms an irreversible covalent bond with the catalytic Cys234 residue of CatC, exerts reversible inhibition via its nitrile moiety, blocks CatC-dependent amyloid formation, and reduces the activation levels of neutrophil serine proteases in bone marrow and blood. AZD5248 reacts with aortic elastin aldehydes to form stable 4-imidazolinones, induces ultrastructural changes in aortic tissue, and has an α-amino acid-based backbone. AZD5248 reduces the severity of acute pancreatitis in mouse models. AZD5248 can be used in research on chronic obstructive pulmonary disease, acute pancreatitis, neurodegenerative diseases, lysosomal storage disorders, acute lung injury, cystic fibrosis, and neutrophil-mediated inflammatory diseases .
Cat. No.: HY-160073
CAS No.: 2762114-61-2
Synonyms: HSK31858
Target:
Research Areas:
Florensocatib (HSK31858) is a potent reversible dipeptidyl peptidase 1 (DPP1) inhibitor with an IC50 of 1.6 nM against DPP1. By inhibiting the DPP1-dependent maturation of neutrophil serine proteases (NSPs), Florensocatib can be used in studies of bronchiectasis and neutrophilic inflammation .
Cat. No.: HY-160073A
CAS No.: 2971064-13-6
Synonyms: HSK31858 hydrate
Target:
Research Areas:
Florensocatib hydrate (HSK31858 hydrate) is a potent reversible dipeptidyl peptidase 1 (DPP1) inhibitor with an IC50 of 1.6 nM against DPP1. Florensocatib hydrate inhibits DPP1 and thereby reduces DPP1-dependent maturation and activation of neutrophil serine proteases (NSPs). Florensocatib hydrate can be used in studies of bronchiectasis and neutrophilic inflammation .
Cat. No.: HY-P701247
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSC; dipeptidyl peptidase I; Prev. PALS; CPPI; Prev. PLS; DPPI; dipeptidyl peptidase 1; dipeptidyl peptidase 1 Isoform A Preproprotein; dipeptidyl Transferase; PDON1; Cathepsin J; HMS; DPP1; JPD; dipeptidyl-peptidase I; JP; Cathepsin C; DPP-I
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P704017
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSC; dipeptidyl peptidase I; Prev. PALS; CPPI; Prev. PLS; DPPI; dipeptidyl peptidase 1; dipeptidyl peptidase 1 Isoform A Preproprotein; dipeptidyl Transferase; PDON1; Cathepsin J; HMS; DPP1; JPD; dipeptidyl-peptidase I; JP; Cathepsin C; DPP-I
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P704009
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSC; dipeptidyl peptidase I; Prev. PALS; CPPI; Prev. PLS; DPPI; dipeptidyl peptidase 1; dipeptidyl peptidase 1 Isoform A Preproprotein; dipeptidyl Transferase; PDON1; Cathepsin J; HMS; DPP1; JPD; dipeptidyl-peptidase I; JP; Cathepsin C; DPP-I
Species:
Human
Source:
HEK293
Cat. No.: HY-P704018
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSC; dipeptidyl peptidase I; Prev. PALS; CPPI; Prev. PLS; DPPI; dipeptidyl peptidase 1; dipeptidyl peptidase 1 Isoform A Preproprotein; dipeptidyl Transferase; PDON1; Cathepsin J; HMS; DPP1; JPD; dipeptidyl-peptidase I; JP; Cathepsin C; DPP-I
Species:
Mouse
Source:
HEK293
Cat. No.: HY-101056R
CAS No.: 1802148-05-5
Synonyms: AZD7986 (Standard); INS 1007 (Standard)
Research Areas:
Brensocatib (Standard) is the analytical standard of Brensocatib (HY-101056). This product is intended for research and analytical applications. Brensocatib (AZD7986) is an oral dipeptidyl peptidase 1 (DPP1) inhibitor with pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively .
Cat. No.: HY-P81084
Synonyms: Angiotensin Converting Enzyme 1; ACE; ACE-T; Angiotensin-converting enzyme isoform 1precursor; dipeptidyl carboxy peptidase 1; Kininase II; ACE-1; testis-specific isoform precursor. ACE 1; ACE T; ACE1; Angiotensin converting enzyme somatic isoform; Angiotensin converting enzyme testis specific isoform; Angiotensin I converting enzyme; Angiotensin I converting enzyme 1; Angiotensin I converting enzyme peptidyl dipeptidase A 1; Carboxycathepsin; CD 143; CD143; CD143 antigen; DCP 1; DCP; DCP1; dipeptidyl carboxypeptidase 1; MVCD3; peptidase P; Peptidyl dipeptidase A; Testicular ECA; ACE_HUMAN.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
