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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
endopeptidase 24.11
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "endopeptidase 24.11" in MCE Product Catalog:
Cat. No.: HY-W345510
CAS No.: 864084-88-8
Target:
Research Areas:
Cat. No.: HY-117702
CAS No.: 135949-60-9
Target:
Prolyl Endopeptidase (PREP) Aminopeptidase Opioid Receptor Dopamine Receptor Drug Intermediate
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
RB 101 is a blood-brain barrier-crossing prodrug as well as aminopeptidase N and neutral endopeptidase-24.11 inhibitor. RB 101 blocks enkephalin breakdown, elevates extracellular enkephalin levels and activate δ-opioid receptor and dopamine D1 receptor. RB 101 can be used for the research of pain, depressive syndromes, and diabetic neuropathy .
Cat. No.: HY-U00171
CAS No.: 100845-83-8
Synonyms: SQ28,603; Squibb 28603
Target:
Research Areas:
SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).
Cat. No.: HY-105351
CAS No.: 150126-87-7
Target:
Research Areas:
CGS25155 is an orally active neutral endopeptidase 24.11 (NEP 24.11) inhibitor with an IC50 of 3 nM. CGS25155 can slow down the degradation of the cardiac hormone atrial natriuretic peptide (ANP) and exhibits antihypertensive activity in the DOCA-salt induced rat hypertension model. CGS25155 can be used in cardiovascular disease research .
Cat. No.: HY-165466
CAS No.: 83960-29-6
Target:
Research Areas:
Azidothiorphan is an irreversible photoaffinity ligand and Endopeptidase 24.11 inhibitor, with a Ki value of 0.75 nM against Endopeptidase 24.11. Upon UV irradiation, Azidothiorphan binds to the active site of enkephalinase, resulting in irreversible loss of enzyme activity. Azidothiorphan produces long-lasting analgesic effects in mice. Azidothiorphan can be used in pain-related research .
Cat. No.: HY-107762
CAS No.: 261619-50-5
Research Areas:
CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1). CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC50 values of 22 nM and 2.3 μM, respectively .
Cat. No.: HY-171461
CAS No.: 147923-04-4
Target:
Research Areas:
CGS 24592 is an orally active, selective and potent neutral endopeptidase 24.11 (NEP) inhibitor with an IC50 value of 1.6 nmol/L. CGS 24592 reduces the degradation of atrial natriuretic peptide (ANP), increases the concentration of ANP in the plasma, and reduces blood pressure. CGS 24592 is promising for research of cardiovascular disease, such as hypertension and congestive heart failure .
Cat. No.: HY-18211
CAS No.: 849066-09-7
Research Areas:
CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC50s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats .
Cat. No.: HY-107761
CAS No.: 148473-36-3
Target:
Research Areas:
JMV 390-1 (Compound 6a) is a potent multipeptidase inhibitor. JMV 390-1 behaves as a full inhibitor of the major neurotensin (NT)/neuromedin N (NN) degrading enzymes in vitro with IC50 values from 30 to 60 nM. JMV 390-1 increases endogenous recovery of NT and NN from slices of mice hypothalamus depolarized with potassium .
Cat. No.: HY-P86377
Synonyms: MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10
Cat. No.: HY-P72876
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MME; Neprilysin-390; Membrane Metalloendopeptidase; Neprilysin-411; Neprilysin; SFE; CALLA; Membrane Metallo-endopeptidase (Neutral endopeptidase, Enkephalinase, CALLA, CD10); NEP; Membrane Metallo-endopeptidase Variant 2; Neutral endopeptidase 24.11; Alt
Species:
Human
Source:
HEK293
Cat. No.: HY-P85080
Synonyms: MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD antigen CD10
Cat. No.: HY-P72878
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MME; Neprilysin-390; Membrane Metalloendopeptidase; Neprilysin-411; Neprilysin; SFE; CALLA; Membrane Metallo-endopeptidase (Neutral endopeptidase, Enkephalinase, CALLA, CD10); NEP; Membrane Metallo-endopeptidase Variant 2; Neutral endopeptidase 24.11; Alt
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P71757
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MME; Neprilysin-390; Membrane Metalloendopeptidase; Neprilysin-411; Neprilysin; SFE; CALLA; Membrane Metallo-endopeptidase (Neutral endopeptidase, Enkephalinase, CALLA, CD10); NEP; Membrane Metallo-endopeptidase Variant 2; Neutral endopeptidase 24.11; Alt
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P72877
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MME; Neprilysin-390; Membrane Metalloendopeptidase; Neprilysin-411; Neprilysin; SFE; CALLA; Membrane Metallo-endopeptidase (Neutral endopeptidase, Enkephalinase, CALLA, CD10); NEP; Membrane Metallo-endopeptidase Variant 2; Neutral endopeptidase 24.11; Alt
Species:
Human
Source:
HEK293
Cat. No.: HY-P703804
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MME; Neprilysin-390; Membrane Metalloendopeptidase; Neprilysin-411; Neprilysin; SFE; CALLA; Membrane Metallo-endopeptidase (Neutral endopeptidase, Enkephalinase, CALLA, CD10); NEP; Membrane Metallo-endopeptidase Variant 2; Neutral endopeptidase 24.11; Alt
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P73746
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MME; Neprilysin-390; Membrane Metalloendopeptidase; Neprilysin-411; Neprilysin; SFE; CALLA; Membrane Metallo-endopeptidase (Neutral endopeptidase, Enkephalinase, CALLA, CD10); NEP; Membrane Metallo-endopeptidase Variant 2; Neutral endopeptidase 24.11; Alt
Species:
Rat
Source:
HEK293
Cat. No.: HY-P72876A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MME; Neprilysin-390; Membrane Metalloendopeptidase; Neprilysin-411; Neprilysin; SFE; CALLA; Membrane Metallo-endopeptidase (Neutral endopeptidase, Enkephalinase, CALLA, CD10); NEP; Membrane Metallo-endopeptidase Variant 2; Neutral endopeptidase 24.11; Alt
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
