83960-29-6
Chemical Structure
Azidothiorphan
- CAS No.: 83960-29-6
- Formula:C12H14N4O3S
- Molecular Weight:294.33
IUPAC Name: (2-(4-azidobenzyl)-3-mercaptopropanoyl)glycine
InChIKey: PXGICQDDGSFSFZ-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NC1=CC=C(C=C1)CC(C(=O)NCC(=O)O)CS
Biological Activity: Azidothiorphan is an irreversible photoaffinity ligand and Endopeptidase 24.11 inhibitor, with a Ki value of 0.75 nM against Endopeptidase 24.11. Upon UV irradiation, Azidothiorphan binds to the active site of enkephalinase, resulting in irreversible loss of enzyme activity. Azidothiorphan produces long-lasting analgesic effects in mice. Azidothiorphan can be used in pain-related research[1].
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Azidothiorphan | Azidothiorphan is an irreversible photoaffinity ligand and Endopeptidase 24.11 inhibitor, with a Ki value of 0.75 nM against Endopeptidase 24.11. Upon UV irradiation, Azidothiorphan binds to the active site of enkephalinase, resulting in irreversible loss of enzyme activity. Azidothiorphan produces long-lasting analgesic effects in mice. Azidothiorphan can be used in pain-related research. | |||||||||||||||||||||
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Keywords
