Search Result
Results for "
fatty acid probe
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-128692
-
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Fluorescent Dye
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Neurological Disease
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Luc Yellow CH dilithium is a high-intensity fluorescent probe containing free hydrazyl groups. Luc Yellow CH can react with fatty aldehydes at room temperature. Luc Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Luc Yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .
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- HY-108910
-
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EC 3.4.21.1; Chymotrypsin A
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Toll-like Receptor (TLR)
NF-κB
MMP
|
Others
Inflammation/Immunology
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Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin downregulates the TLR4/NF-κB signaling pathway, inhibiting the release of inflammatory factors, reducing cell infiltration and tissue damage. It also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54) and can be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions. It can be used in research on diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin can be used in studies of inflammation, edema, and expectoration .
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-
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- HY-W127715
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Fluorescent Dye
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Others
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Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .
|
-
-
- HY-N16308
-
|
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Fluorescent Dye
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Others
|
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ER-Laurdan is a derivative of the membrane-permeable fluorescent probe Laurdan (HY-D0080) that targets the endoplasmic reticulum (ER). As a membrane fluidity reporter, ER-Laurdan specifically localizes to the ER luminal membrane, and exhibits a prominent solvatochromic response to fluidity changes caused by membrane packing and exogenous saturated fatty acid stress. ER-Laurdan shows no overlapping localization with mitochondria, enables quantitative analysis of ER membrane fluidity via generalized polarization ratio measurement, and allows automatic signal masking with the help of ER markers. With high specificity and quantitative capability, ER-Laurdan serves as an important tool for investigating metabolic disorders and associated changes in the physical properties of cell membranes .
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- HY-W020012
-
|
22-NBD Cholesterol
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Fluorescent Dye
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Metabolic Disease
|
|
Fluoresterol (22-NBD Cholesterol) is a cholesterol-specific fluorescent probe with cholesterol-mimicking binding properties. Fluoresterol is ineffective orally and does not cross the blood-brain barrier. Fluoresterol specifically binds to cholesterol transport-related proteins (such as ABCA1 and ABCG1) and is primarily used in cholesterol metabolism research, particularly for the visualization and quantitative analysis of cholesterol absorption, efflux, intracellular transport efficiency, and reverse cholesterol transport (RCT) processes. The commonly used concentration of Fluoresterol in in vitro experiments is 0.1-10 μM, and the commonly used dose in in vivo experiments is 5-20 mg/kg (gavage or intraperitoneal injection), with excitation/emission wavelengths of 472/540 nm. Fluoresterol can be applied to the study of cholesterol metabolism mechanisms related to hyperlipidemia, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD) .
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-
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- HY-D1617
-
|
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Fluorescent Dye
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Others
|
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BODIPY 500/510 C1, C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 500/510 nm . Protect from light, stored at -20°C.
|
-
-
- HY-108910A
-
|
EC 3.4.21.1 (MS grade); Chymotrypsin A (MS grade)
|
Toll-like Receptor (TLR)
NF-κB
MMP
|
Others
Inflammation/Immunology
|
|
Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) (MS grade) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin (MS grade) downregulates the TLR4/NF-κB signaling pathway, inhibits the release of inflammatory factors, reduces cell infiltration and tissue damage, and also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54). It can also be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin (MS grade) has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions, and can be used in the research of diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin (MS grade) can be used in studies of inflammation, edema, and expectoration .
|
-
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- HY-16100
-
|
|
Fatty Acid Synthase (FASN)
|
Metabolic Disease
Cancer
|
|
BI 99179, a chemical probe, is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats .
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- HY-117401
-
|
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Fluorescent Dye
|
Others
|
|
5-Dodecanoylaminofluorescein is an amphipathic (amphoteric) fluorescent probe (Ex/Em = 485 nm/515-535 nm), which consists of a hydrophilic fluorescein core and a hydrophobic dodecanoyl group (C12 fatty acid chain) linked by an amide bond. 5-Dodecanoylaminofluorescein is mainly used as an interface-localized radical trapping/indicator probe. Dodecanoylaminofluorescein can be used for the determination of the antioxidant properties of emulsions, or can serve as a lipophilic drug model for the study of passive skin penetration when encapsulated in tyrosine-derived nanospheres .
|
-
-
- HY-147309
-
|
|
Fluorescent Dye
|
Others
|
|
16-Azidohexadecanoic acid, a synthetic fatty acid, can be used as a modification marker for nucleotides and a molecular probe for fatty acid metabolism . 16-Azidohexadecanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
-
- HY-174790
-
|
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mRNA
|
Cancer
|
|
Firefly Luciferase mRNA is a reporter mRNA that can be transfected into cells to express firefly luciferase protein. Firefly Luciferase mRNA induces cytotoxicity in cancer cells at low concentrations. In cancer cells, the expression level of luciferase shows a non-linear relationship with the dose of Firefly Luciferase mRNA. When combined with the H2S-responsive bioluminescent probe (H-Luc), Firefly Luciferase mRNA enables bioluminescence-based detection of endogenous hydrogen sulfide in non-transgenic NAFLD cell models and NAFLD mouse models. Firefly Luciferase mRNA can be used in studies related to non-alcoholic fatty liver disease .
|
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- HY-160147
-
|
Palmitoleic acid alkyne
|
Biochemical Assay Reagents
|
Others
|
|
(Z)-Hexadec-9-en-15-ynoicacid (Palmitoleic acid alkyne) is an unsaturated alkynyl-palmitoleic acid alkyne used as alkynyl fatty acid probe .
|
-
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- HY-D2857
-
|
|
Fluorescent Dye
|
Metabolic Disease
|
|
NBD-Stearic acid is a stearic acid labeled with a nitrobenzoxadiazole (NBD) fluorophore. NBD-Stearic acid can be used as a probe for fatty acid uptake or the the ligand binding sites of fatty acid and sterol carrier proteins (FABP)
|
-
-
- HY-D2911
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
Pantetheine probe PP-3 (Compound PP-3) is an alkynyl group connector probe. Pantetheine probe PP-3 selectively enriches and maps modification sites (e.g., Ser231 on DHRS2). Pantetheine probe PP-3 is promising for research of metabolic disorders (e.g., fatty acid synthesis dysregulation) .
|
-
-
- HY-173587
-
|
1,2-Bis(heptanoylthio) glycerophosphatidylglycerol sodium
|
Phospholipase
|
Metabolic Disease
|
|
1,2-Bis(heptanoylthio)-sn-glycero-3-PG (1,2-Bis(heptanoylthio) glycerophosphatidylglycerol) sodium is a fatty acylthioesterified phosphatidylglycerol derivative that can be used to mimic the action of phospholipases or as a probe molecule for membrane fusion studies .
|
-
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- HY-179548
-
|
|
Drug Derivative
|
Others
|
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Photoclick palmitic acid is a derivative of the long-chain saturated fatty acid palmitic acid (HY-N0830). The photoclick-type long-chain saturated fatty acid has been used as a probe for studying protein lipidation .
|
-
-
- HY-D3012
-
|
|
Fluorescent Dye
|
Others
|
|
12-AS is a 9-anthracenoxy fatty acid probe. 12-AS’s fluorescence decay is not a single index, and its lifetime increases with the red shift of the emission wavelength .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-128692
-
|
|
Fluorescent Dyes
|
|
Luc Yellow CH dilithium is a high-intensity fluorescent probe containing free hydrazyl groups. Luc Yellow CH can react with fatty aldehydes at room temperature. Luc Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Luc Yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .
|
-
- HY-W127715
-
|
|
Fluorescent Dyes
|
|
Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .
|
-
- HY-D1617
-
|
|
Fluorescent Dyes
|
|
BODIPY 500/510 C1, C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 500/510 nm . Protect from light, stored at -20°C.
|
-
- HY-117401
-
|
|
Fluorescent Dyes
|
|
5-Dodecanoylaminofluorescein is an amphipathic (amphoteric) fluorescent probe (Ex/Em = 485 nm/515-535 nm), which consists of a hydrophilic fluorescein core and a hydrophobic dodecanoyl group (C12 fatty acid chain) linked by an amide bond. 5-Dodecanoylaminofluorescein is mainly used as an interface-localized radical trapping/indicator probe. Dodecanoylaminofluorescein can be used for the determination of the antioxidant properties of emulsions, or can serve as a lipophilic drug model for the study of passive skin penetration when encapsulated in tyrosine-derived nanospheres .
|
-
- HY-D2857
-
|
|
Fluorescent Dyes
|
|
NBD-Stearic acid is a stearic acid labeled with a nitrobenzoxadiazole (NBD) fluorophore. NBD-Stearic acid can be used as a probe for fatty acid uptake or the the ligand binding sites of fatty acid and sterol carrier proteins (FABP)
|
-
- HY-D2911
-
|
|
Fluorescent Dyes
|
|
Pantetheine probe PP-3 (Compound PP-3) is an alkynyl group connector probe. Pantetheine probe PP-3 selectively enriches and maps modification sites (e.g., Ser231 on DHRS2). Pantetheine probe PP-3 is promising for research of metabolic disorders (e.g., fatty acid synthesis dysregulation) .
|
-
- HY-D3012
-
|
|
Fluorescent Dyes
|
|
12-AS is a 9-anthracenoxy fatty acid probe. 12-AS’s fluorescence decay is not a single index, and its lifetime increases with the red shift of the emission wavelength .
|
| Cat. No. |
Product Name |
Type |
-
- HY-108910
-
|
EC 3.4.21.1; Chymotrypsin A
|
Biochemical Assay Reagents
|
|
Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin downregulates the TLR4/NF-κB signaling pathway, inhibiting the release of inflammatory factors, reducing cell infiltration and tissue damage. It also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54) and can be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions. It can be used in research on diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin can be used in studies of inflammation, edema, and expectoration .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N16308
-
|
|
Structural Classification
Lipid
|
Fluorescent Dye
|
|
ER-Laurdan is a derivative of the membrane-permeable fluorescent probe Laurdan (HY-D0080) that targets the endoplasmic reticulum (ER). As a membrane fluidity reporter, ER-Laurdan specifically localizes to the ER luminal membrane, and exhibits a prominent solvatochromic response to fluidity changes caused by membrane packing and exogenous saturated fatty acid stress. ER-Laurdan shows no overlapping localization with mitochondria, enables quantitative analysis of ER membrane fluidity via generalized polarization ratio measurement, and allows automatic signal masking with the help of ER markers. With high specificity and quantitative capability, ER-Laurdan serves as an important tool for investigating metabolic disorders and associated changes in the physical properties of cell membranes .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-147309
-
|
|
|
Azide
|
|
16-Azidohexadecanoic acid, a synthetic fatty acid, can be used as a modification marker for nucleotides and a molecular probe for fatty acid metabolism . 16-Azidohexadecanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-160147
-
|
Palmitoleic acid alkyne
|
|
Alkynes
|
|
(Z)-Hexadec-9-en-15-ynoicacid (Palmitoleic acid alkyne) is an unsaturated alkynyl-palmitoleic acid alkyne used as alkynyl fatty acid probe .
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-174790
-
|
|
|
mRNA
Reporter Genes
|
|
Firefly Luciferase mRNA is a reporter mRNA that can be transfected into cells to express firefly luciferase protein. Firefly Luciferase mRNA induces cytotoxicity in cancer cells at low concentrations. In cancer cells, the expression level of luciferase shows a non-linear relationship with the dose of Firefly Luciferase mRNA. When combined with the H2S-responsive bioluminescent probe (H-Luc), Firefly Luciferase mRNA enables bioluminescence-based detection of endogenous hydrogen sulfide in non-transgenic NAFLD cell models and NAFLD mouse models. Firefly Luciferase mRNA can be used in studies related to non-alcoholic fatty liver disease .
|
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