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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
galactose metabolism
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "galactose metabolism" in MCE Product Catalog:
5
5 Cited Publications
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β1-3 Galactosidase is a GH42 exoglycosidase that specifically hydrolyzes terminal β1-3-linked galactose. β1-3 Galactosidase uses Glu164 as the acid/base catalyst and Glu324 as the catalytic nucleophile to hydrolyze β1-3 galactosidic linkages. β1-3 Galactosidase can be used for research on galactoside metabolism .
Category:
Human Gut Microbiota Metabolites Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields
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Cat. No.: HY-W150340
CAS No.: 5965-66-2
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β-Lactose is a disaccharide commonly found in milk and dairy products. It consists of two monosaccharides, glucose and galactose, linked by β-glycosidic bonds. β-Lactose has various applications in the food industry, especially as a sweetener and bulking agent. Furthermore, it can be used as a substrate for enzymes involved in lactose metabolism and as a model compound for studying carbohydrate-protein interactions.
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Thiobis-β-Galactose-propyne is an effective multivalent galectin-3 (Gal-3) inhibitor. Galectin-3 is involved in many metabolism processes related to cancer. Galectin-3-IN-1 is a click chemistry reagent. It contains an alkyne group that can undergo a copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction with molecules that have an azide group .
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N-acetyl-D-galactosamine 6-phosphate is a galactosamine phosphate that involved in galactose metabolism and phosphotransferase system (PTS). N-Acetyl-D-galactosamine-6-phosphate can be hydrolyze by NagA .
Cat. No.: HY-W039921
CAS No.: 869186-83-4
Synonyms: N-Azidoacetylgalactosamine; GalNAz
Cat. No.: HY-114364S
Purity: ≥98.0%
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Cat. No.: HY-W768246
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Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of galactose to glucose. Galactose-1-phosphate uridylyltransferase absence results in classic galactosemia in humans and can be used for metabolic disease research .
Cat. No.: HY-W601362
CAS No.: 102029-88-9
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N-Acetyl-D-galactosamine-6-phosphate disodium is a galactosamine phosphate that involved in galactose metabolism and phosphotransferase system (PTS). N-Acetyl-D-galactosamine-6-phosphate disodium can be hydrolyze by NagA .
Cat. No.: HY-E71393
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1-Phosphatidylinositol 4-kinase (EC 2.7.1.67) is the first key enzyme involved in the Leloir galactose metabolism pathway (Leloir pathway), responsible for phosphorylating D-galactose into galactose-1-phosphate (Gal-1-P).
Cat. No.: HY-E71023
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Uridine-5'-diphosphogalactose 4-epimerase, Galactose-adapted yeast (EC 5.1.3.2) is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose.
Cat. No.: HY-E70891
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β-Galactose Dehydrogenase S, Pseudomonas fluorescens (EC 1.1.1.48) belongs to the oxidoreductase family and is an oxidoreductase that acts on the CH-OH group as a donor and uses NAD+ or NADP+ as an acceptor. β-Galactose Dehydrogenase S, Pseudomonas fluorescens, is involved in galactose metabolism. The enzyme's two substrates are D-galactose and NAD+, while its three products are D-galactonide-1,4-lactone, NADH, and H+.
Cat. No.: HY-L133
446 compounds
Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".
The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.
Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.
Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.
MCE supplies a unique collection of 446 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
