Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
76 Results for "
glial cell
" in MedChemExpress (MCE) Product Catalog:
Products (76)
76 Results for "glial cell" in MCE Product Catalog:
12
12 Publications Verification
Cat. No.: HY-K3001
DMEM (Dulbecco's Modified Eagle Medium) is a widely used basal medium for supporting the growth of many different mammalian cells. Cell lines successfully cultured in DMEM include Hela, 293, Cos-7, and PC-12, as well as primary fibroblasts, neurons, glial cells, HUVECs, and smooth muscle cells. The 500 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
8
8 Cited Publications
Cat. No.: HY-K3002
DMEM/F-12 (Dulbecco's Modified Eagle Medium/Nutrient Mixture F-12) is a widely used basal medium for supporting the growth of many different mammalian cells. Cell successfully cultured in DMEM/F-12 include MDCK, glial cells, fibroblasts, human endothelial cells, etc. The 500 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
6
Category:
Natural Products Anti-aging Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Other Diseases Disease markers Disease Research Fields
Target:
5
5 Cited Publications
Cat. No.: HY-P7182
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; glial cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; glial cell Line Derived Neurotrophic Factor; glial cell Line-Derived Neurotrophic Factor; glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Human
Source:
E. coli
3
Target:
Research Areas:
TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC50 values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs .
2
2 Cited Publications
Cat. No.: HY-P7359
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; glial cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; glial cell Line Derived Neurotrophic Factor; glial cell Line-Derived Neurotrophic Factor; glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Mouse
Source:
CHO
2
2 Cited Publications
Cat. No.: HY-P71617
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: METRNL; Cometin; Meteorin Like, glial cell Differentiation Regulator; Meteorin, glial cell Differentiation Regulator-Like; Meteorin-Like Protein; METRNL Protein; Subfatin
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes .
1
1 Cited Publications
Target:
Research Areas:
BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF) . BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function .
1
Category:
Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus wallichiana Zucc.
Target:
1
1 Cited Publications
Cat. No.: HY-P73074
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDNF; ATF2; glial cell Derived Neurotrophic Factor; ATF; Astrocyte-Derived Trophic Factor; glial cell Line Derived Neurotrophic Factor; glial cell Line-Derived Neurotrophic Factor; glial Derived Neurotrophic Factor; HFB1-GDNF; HSCR3; ATF1; HGDNF
Species:
Human
Source:
HEK293
Target:
Cat. No.: HY-B0696A
CAS No.: 145821-59-6
Synonyms: NO050328 hydrochloride; NO328 hydrochloride; TGB hydrochloride
Target:
Research Areas:
Tiagabine hydrochloride (NO050328; NO328; TGB) is an orally active, highly selective, and reversible GAT-1 inhibitor and anticonvulsant that crosses the blood-brain barrier. By blocking the reuptake of GABA in neurons and glial cells, tiagabine increases extracellular GABA levels to enhance inhibitory signal transduction, thereby exerting multiple activities such as anticonvulsant, neuroprotective, and antioxidant effects. Tiagabine hydrochloride exhibits linear pharmacokinetic properties. Although it is metabolized by CYP3A and has a high protein binding rate, it carries a low risk of cognitive impairment. Tiagabine hydrochloride is widely used in research on related diseases including epilepsy (including refractory partial seizures), alcohol withdrawal symptoms, and Huntington's disease .
Cat. No.: HY-B0696
CAS No.: 115103-54-3
Synonyms: NO050328; NO328; TGB
Target:
Research Areas:
Tiagabine (NO050328; NO328; TGB) is an orally active, highly selective, and reversible GAT-1 inhibitor and anticonvulsant that crosses the blood-brain barrier. By blocking the reuptake of GABA in neurons and glial cells, tiagabine increases extracellular GABA levels to enhance inhibitory signal transduction, thereby exerting multiple activities such as anticonvulsant, neuroprotective, and antioxidant effects. Tiagabine exhibits linear pharmacokinetic properties. Although it is metabolized by CYP3A and has a high protein binding rate, it carries a low risk of cognitive impairment. Tiagabine is widely used in research on related diseases including epilepsy (including refractory partial seizures), alcohol withdrawal symptoms, and Huntington's disease .
Cat. No.: HY-W002199
CAS No.: 647-42-7
Synonyms: 6:2 FTOH; 1H,1H,2H,2H-Perfluoro-1-octanol; 2-(Perfluorohexyl)ethanol
Target:
Research Areas:
6:2 Fluorotelomer alcohol (6:2 FTOH) is an orally active, blood-brain barrier-permeable modulator of cyclin D1 and ETS1. 6:2 Fluorotelomer alcohol downregulates cyclin D1 expression, upregulates ETS1 via the TNF-α/ERK 1/2 pathway, impairs mitochondrial membrane potential and respiratory function, increases reactive oxygen species levels, disrupts calcium homeostasis and activates endoplasmic reticulum stress markers, and induces cell proliferation inhibition and endothelial-mesenchymal transition. Furthermore, 6:2 Fluorotelomer alcohol induces morphological abnormalities in zebrafish embryos and liver developmental damage, while disrupting the brain immune microenvironment in mice, causing systemic toxicity and delayed pup maturation in CD-1 mice. 6:2 Fluorotelomer alcohol also induces cortical neuron apoptosis, glial cell activation, synaptic abnormalities, colonic barrier damage, intestinal dysbiosis and autism spectrum disorder-like symptoms in mice. 6:2 Fluorotelomer alcohol shows no mutagenic, clastogenic, primary skin/eye irritation or skin sensitizing effects, exhibits no selective reproductive toxicity in CD-1 mice, and is classified as GHS Category 4 for acute oral toxicity. 6:2 Fluorotelomer alcohol can be used in studies of neurodevelopmental disorders and autism spectrum disorders .
Cat. No.: HY-P1777
CAS No.: 135861-49-3
Synonyms: Insulin-like Growth Factor I (24-41)
Target:
Research Areas:
Cat. No.: HY-B1197
CAS No.: 51022-69-6
Synonyms: CL-34699
Research Areas:
Amcinonide is an inhibitor of NO release (IC50 = 3.38 nM). Amcinonide inhibits NNC-induced expression of the proinflammatory genes iNOS, TNF-α, and IL-1β in glial cells. Amcinonide reduces the numbers of T6+/Ia+ cells with a concomitant increase in T6+/Ia- cells. Amcinonide induces a selective reduction in expression of Ia antigens. Amcinonide can also be studied in research for eczematous dermatitis .
Cat. No.: HY-139201H
CAS No.: 27964-99-4
Synonyms: PDLHB (MW ≥300000)
0 Images
ION-626112 (sodium)
Cat. No.: HY-159693A
Synonyms: ION-626112 sodium
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
