135861-49-3
Chemical Structure
IGF-I (24-41)
Synonym(s): Insulin-like Growth Factor I (24-41)
- CAS No.: 135861-49-3
- Formula:C88H133N27O28
- Molecular Weight:2017.16
InChIKey: HLOCSQLWBVBRQV-FZKVNNNNSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](N)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N3[C@@H](CCC3)C(N[C@@H]([C@H](O)C)C(NCC(N[C@H](C(NCC(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N4[C@@H](CCC4)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development[1][2][3].
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IGF-I (24-41) | 99.84% | IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development. | ||||||||||||||||||||
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References
- [1]. Puche JE, et al. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med. 2012 Nov 14;10:224. [Content Brief]
- [2]. D Santucci, et al. IGF-I and IGF-I24-41 but not IGF-I57-70 affect somatic and neurobehavioral development of newborn male mice. Brain Res Bull. 1994;35(4):367-71. [Content Brief]
- [3]. Dan Meng, et al. Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species. Free Radic Biol Med. 2007 Jun 1;42(11):1651-60. [Content Brief]
