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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
human μ-opioid receptor
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "human μ-opioid receptor" in MCE Product Catalog:
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Naldemedine (S-297995) tosylate is an orally active μ-opioid receptor antagonist (PAMORA) . Naldemedine tosylate shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors . Naldemedine can be used in opioid-induced constipation (OIC) research . Naldemedine tosylate is predicted to bind to 3CL pro encoded by SARS-CoV2 genome .
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1 Cited Publications
Cat. No.: HY-P1502
CAS No.: 61214-51-5
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1 Cited Publications
Cat. No.: HY-N2392
CAS No.: 75288-96-9
Cat. No.: HY-P1626
CAS No.: 928007-64-1
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Category:
Infection Alkaloids other families Monophenols Phenols Plants Disease Research Fields Isoquinoline Alkaloids
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Cat. No.: HY-19627
CAS No.: 916072-89-4
Synonyms: S-297995
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Naldemedine (S-297995) is an orally active μ-opioid receptor antagonist (PAMORA) . Naldemedine shows potent binding affinities (Ki=0.34, 0.43, 0.94 nM, respectively) and antagonist activities (IC50=25.57, 7.09, 16.1 nM, respectively) for recombinant human μ-, δ-, and κ- opioid receptors . Naldemedine can be used in opioid-induced constipation (OIC) research . Naldemedine is predicted to bind to 3CL pro encoded by SARS-CoV2 genome .
Cat. No.: HY-121854A
CAS No.: 81447-81-6
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Bromadoline maleate is an opioid analgesic selective for the μ-opioid receptor, exhibiting analgesic activity in various biological fluids. Bromadoline maleate has been successfully quantified alongside its N-demethylated metabolites in human and canine samples.
Cat. No.: HY-P11642A
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Cat. No.: HY-P1502F
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Cat. No.: HY-122286
CAS No.: 272104-60-6
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SB 414240 is a selective neurokinin-2 receptor (NK-2R) antagonist with Kis of 1 nM and 193 nM for human NK-3R and human NK-2R, respectively. SB 414240 does not bind the human μ-opioid receptor (hMOR). SB 414240 can be used for the study of neurological disease .
Cat. No.: HY-P3517
CAS No.: 77761-27-4
Synonyms: β-EP (6-31), human
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Cat. No.: HY-P1253
CAS No.: 59004-96-5
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α-Endorphin (human, mouse, rat, porcine, bovine, ovine) is a neuropeptide, that acts on the central nervous system (CNS) and peripheral nervous system (PNS). α-Endorphin (human, mouse, rat, porcine, bovine, ovine) binds μ-opioid receptor, and exhibits analgesic efficacy. α-Endorphin (human, mouse, rat, porcine, bovine, ovine) regulates sexual behaviors and pleasure felling .
Cat. No.: HY-P702403
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: OPRM1; Mu opioid receptor Splice Variant HMOR-1S; opioid receptor Mu 1; Mu opioid receptor Splice Variant MOR-1H; MOR1; Mu opioid receptor HMOR-1a; MOP; Mutant opioid receptor Mu; Mu-Type opioid receptor; Mu opioid receptor MOR-1O; Mu Opiate receptor; Opi
Species:
Human
Source:
E. coli Cell-free
Cat. No.: HY-W414109
CAS No.: 1172882-21-1
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ID110460002 possesses both full agonist activity at the μ-opioid receptor (OPRM) and agonist activity at the δ-opioid receptor (OPRD). ID110460002 acts as a potent agonist for the G protein pathways of both receptors, but exhibits only very weak partial agonist activity towards the β-arrestin-2 pathway. The agonistic potency of ID110460002 at OPRM has extremely high intrinsic activity and is unaffected by reduced receptor expression levels, while its potency at OPRD depends on receptor expression levels. ID110460002 displays tissue- or organ-dependent properties, and serves as a critical compound for investigating pain mechanisms and analgesia .
Cat. No.: HY-172419A
CAS No.: 3048183-44-1
Synonyms: GM-1020 hydrochloride
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Blixeprodil hydrochloride (GM-1020 hydrochloride) is an orally active, blood-brain barrier-penetrant NMDA receptor inhibitor with a Ki of 3.25 µM in rat cortical tissues. Blixeprodil hydrochloride binds to the MK-801 ion channel site and blocks NMDA receptor-mediated currents in hyperpolarized states in a voltage-dependent manner. Blixeprodil hydrochloride modulates the power of cortical EEG frequency bands, alters spontaneous motor activity, and induces ataxia at high doses. Blixeprodil hydrochloride can be used in the research of depression .
Cat. No.: HY-E72110
Human UGT1A8 is a UDP-glucuronosyltransferase. Human UGT1A8 catalyzes the transfer of glucuronosyl group from UDPGA to Dihydrotestosterone, forming DHT monoglucuronide. Human UGT1A8 catalyzes the transfer of glucuronosyl group from UDPGA to DHT monoglucuronide, introducing a second glucuronosyl group at the C2 ' position of the latter to form DHT diglucuronide. Human UGT1A8 catalyzes the glucuronidation reactions of coumarins, anthraquinones, flavonoids, phenolic compounds, catechol estrogens, primary amines including 4-Aminobiphenyl, and some opioids .
Cat. No.: HY-181103
CAS No.: 2059904-64-0
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ERG-IN-6 (compound (+)-(S)-5a) is a μ-opioid receptor activator with an EC50 of 0.12 nM. ERG-IN-6 also is a hERG (Kv11.1) potassium channel inhibitor with an IC50 of 0.681 μM. ERG-IN-6 can be used for the research of pain .
Cat. No.: HY-W099633
CAS No.: 17702-88-4
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2-Aminodecanoic acid is a lipophilic α-amino acid with an aliphatic side chain of 10 carbon atoms. 2-Aminodecanoic acid modifies the N-terminus of endogenous opioid peptide endomorphin-1 to enhance metabolic stability and membrane permeability. 2-Aminodecanoic acid can be used for the research of neuropathic pain .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
