Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
hydrolytic metabolite
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "hydrolytic metabolite" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-W018781
CAS No.: 1670-14-0
Target:
Research Areas:
Benzamidine hydrochloride is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine hydrochloride effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine hydrochloride undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine hydrochloride only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine hydrochloride may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine hydrochloride can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results .
4
Target:
Research Areas:
Benzamidine is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results .
4
4 Cited Publications
Cat. No.: HY-W087937
CAS No.: 206752-36-5
Synonyms: Benzenecarboximidamide hydrochloride hydrate
Target:
Synonyms: AR-13324 M1 metabolite
Research Areas:
AR-13503 (AR-13324 M1 metabolite) is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research .
Cat. No.: HY-N7177
CAS No.: 18887-18-8
Category:
Quinones Labiatae Samanea saman (Jacq.) Merr. Plants Disease Research Fields Naphthalene Quinones Cancer
Target:
Cat. No.: HY-W010115
CAS No.: 1563-38-8
Research Areas:
Carbofuran phenol is a hydrolytic metabolite of the Carbofuran pesticide. Carbofuran phenol is promising for research of environmental bioremediation fields .
Cat. No.: HY-W856819
CAS No.: 469-22-7
Research Areas:
Eseroline is a potent μ-opioid receptor agonist, which is the hydrolytic metabolite of Physostigmine (HY-N6608). Eseroline is a selective and competitive acetylcholinesterase (AChE) inhibitor, with its Ki values for AChE and BuChE being 0.1 μM and 200 μM respectively. Eseroline has nicotinic acetylcholine receptor allosteric enhancing ligand (nAChR-APL) activity, meaning it does not activate the receptor but significantly enhances the signal transduction of Ach triggered by the receptor. Eseroline is neurotoxic, causing cell membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion). Eseroline can be used for the study of Alzheimer's disease .
Synonyms: (R)-AR-13324 M1 metabolite
Target:
Research Areas:
(R)-AR-13503 ((R)-AR-13324 M1 metabolite) is the the (R)-enantiomer of AR-13503 (HY-12798C). AR-13503 is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research .
Cat. No.: HY-136820S1
Cat. No.: HY-W018781R
CAS No.: 1670-14-0
Target:
Research Areas:
Benzamidine hydrochloride (Standard) is the analytical standard of Benzamidine (hydrochloride). This product is intended for research and analytical applications. Benzamidine hydrochloride is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine hydrochloride effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine hydrochloride undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine hydrochloride only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine hydrochloride may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine hydrochloride can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results .
Target:
Research Areas:
N-Desmethyl dimethoate is a metabolite of Dimethoate (HY-B1946). N-Desmethyl dimethoate undergoes hydrolytic degradation in common bean plants. Dimethoate is an organophosphorus insecticide and acaricide .
Cat. No.: HY-133841
CAS No.: 32746-94-4
Synonyms: Ampicillin impurity D
Target:
Research Areas:
Ampicilloic acid (Ampicillin impurity D) is a hydrolytic metabolite of the penicillin antibiotic Ampicillin (HY-B0522), produced by Alcanivorax sp. via β-lactamase-mediated β-lactam ring opening reaction .
Cat. No.: HY-E70973
Target:
Research Areas:
β-Glucuronidase/Arylsulfatase, Helix pomatia is an enzyme with arylsulfatase activity that is isolated from Roman snails (Helix pomatia). β-Glucuronidase/Arylsulfatase, Helix pomatia exhibits broad-spectrum hydrolytic specificity towards various β-glucuronides and sulfate conjugates. β-Glucuronidase/Arylsulfatase, Helix pomatia is used for simultaneous deconjugation of drug-conjugated metabolites in urine samples .
Cat. No.: HY-136820
CAS No.: 38668-01-8
Research Areas:
Taurultam is the major active hydrolytic metabolite of Taurolidine (HY-W011522), which selectively activates hTRPA1 to trigger effects in sensory neurons. Taurultam exhibits activity against SARS-CoV-2 variants, influenza A viruses (H1N1, H3N2) and influenza B viruses. Taurultam induces mild tracheal sensory nerve stimulation and CGRP release in mice. Taurultam can be used in studies related to SARS-CoV-2 infection, influenza virus infection, and co-infection with SARS-CoV-2 and influenza A virus.
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
