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Results for "

intrahepatic cholestasis

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Fluorescent Dyes

1

Peptides

5

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0172
    Lithocholic acid
    15+ Cited Publications

    3α-Hydroxy-5β-cholanic acid

    		 Autophagy Endogenous Metabolite Apoptosis FXR Metabolic Disease Inflammation/Immunology Cancer
    Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist .
    Lithocholic acid
  • HY-113315
    3b-Hydroxy-5-cholenoic acid

    		Endogenous Metabolite Metabolic Disease
    3β-Hydroxy-5-cholenoic acid is a steroidal monohydroxy bile acid and serves as a substrate for sulfation reactions. It is applicable to the research of extrahepatic biliary atresia and recurrent intrahepatic cholestasis of pregnancy .
    3b-Hydroxy-5-cholenoic acid
  • HY-16747
    Maralixibat chloride

    SHP625 chloride; LUM001 chloride; Lopixibat chloride

    		 Apical Sodium-Dependent Bile Acid Transporter Metabolic Disease
    Maralixibat (SHP625) chloride is an orally active ileal bile acid transporter (IBAT) inhibitor. Maralixibat chloride can be used for the research of rare cholestatic liver diseases including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC) and biliary atresia .
    Maralixibat chloride
  • HY-B0172R
    Lithocholic acid (Standard)
    15+ Cited Publications

    3α-Hydroxy-5β-cholanic acid (Standard)

    		 Reference Standards Autophagy Endogenous Metabolite Apoptosis FXR Metabolic Disease Cancer
    Lithocholic acid (Standard) is the analytical standard of Lithocholic acid. This product is intended for research and analytical applications. Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist .
    Lithocholic acid (Standard)
  • HY-129987
    Estradiol 17-(β-D-Glucuronide) sodium

    		Endogenous Metabolite P-glycoprotein Metabolic Disease
    Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) sodium is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) sodium regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) sodium induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) sodium can be used in studies related to intrahepatic cholestasis .
    Estradiol 17-(β-D-Glucuronide) sodium
  • HY-W353102
    Estradiol 17-(β-D-Glucuronide)

    		Endogenous Metabolite P-glycoprotein Metabolic Disease
    Estradiol 17-(β-D-Glucuronide) is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) can be used in studies related to intrahepatic cholestasis .
    Estradiol 17-(β-D-Glucuronide)
  • HY-168523
    S1647

    		Apical Sodium-Dependent Bile Acid Transporter Metabolic Disease
    S1647 is a ASBT and SOAT dual inhibitor. S1647 can be used in the study of intrahepatic cholestasis, cholestatic pruritus, and obstipation .
    S1647
  • HY-P1654A
    A20FMDV2-Cys

    		Integrin Cancer
    A20FMDV2-Cys is a cysteine-containing 20-mer peptide that targets integrin αvβ6 with high affinity. A20FMDV2-Cys can be used for targeted liposome modification to enhance liver and bile duct targeting. A20FMDV2-Cys is applicable for research in drug delivery .
    A20FMDV2-Cys
  • HY-D3304
    Cholyl-L-lysine fluorescein disodium

    		Fluorescent Dye Others
    Cholyl-L-lysine fluorescein disodium is a Fluorescent substrate. Cholyl-L-lysine fluorescein disodium can be used in organoid research .
    Cholyl-L-lysine fluorescein disodium

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