Human UGT2B4
Human UGT2B4 is a UDP-glucuronosyltransferase. UGT2B4 catalyzes the glucuronidation of bile acids, Carvedilol (HY-B0006) and 6-hydroxylated bile acids to form glucuronide derivatives. UGT2B4 participates in the inactivation of endogenous and exogenous substances, including catechol estrogens, C19 steroids, phenols and monoterpenoids. Human UGT2B4 can be used in the research of hypertension, angina pectoris, chronic heart failure and intrahepatic cholestasis.
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Biologische Aktivität
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UGT2B4 |
Human UGT2B4 (expressed in insect cell microsomes) catalyzes the formation of carvedilol (HY-B0006) glucuronides G1 and G2, with a higher catalytic efficiency for G1 production (Vmax/Km = 0.33 μl/min/mg protein) than for G2 production (Vmax/Km = 0.12 μl/min/mg protein)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[Human UGT2B4]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Monaghan G, et al. Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase. Mamm Genome. 1997 Sep;8(9):692-4. [Content Brief]
[2]. Ohno A, et al. Involvement of human hepatic UGT1A1, UGT2B4, and UGT2B7 in the glucuronidation of carvedilol. Drug metabolism and disposition: the biological fate of chemicals. 2004 Feb;32(2):235-9. [Content Brief]
[3]. Barbier O, et al. FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology. 2003 Jun;124(7):1926-40. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Human UGT2B4 Related Classifications
HY-E72116 Related Classifications
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