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isolated mitochondria

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By Targets:	Acyltransferase (1) Akt (1) Antibiotic (3) Apoptosis (12) Atg7 (1) Atg8/LC3 (1) Autophagy (2) Bacterial (1) Bcl-2 Family (2) Carnitine Palmitoyltransferase (CPT) (1) Caspase (3) DNA/RNA Synthesis (4) Dynamin (2) Endogenous Metabolite (2) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (1) JAK (1) JNK (1) Liposome (1) Mitochondrial Metabolism (8) Mitophagy (2) MMP (1) mTOR (1) Oxidative Phosphorylation (3) p62 (1) PARP (1) Pim (1) PINK1/Parkin (2) Proteasome (2) Reactive Oxygen Species (ROS) (3) Reference Standards (2) STAT (1)
By Research Areas:	Cancer (17) Infection (4) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (1)
Oligonucleotides:	Phospholipids (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0636

Eriocitrin 5 Publications Verification Eriodictyol 7-rutinoside; Eriodictyol 7-O-rutinoside	Apoptosis	Cancer
Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria .

HY-N10470

Bleomycin A5 1 Publications Verification Pingyangmycin	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy	Infection Cancer
Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research .

HY-N7056

4'-Hydroxychalcone 3 Publications Verification	Oxidative Phosphorylation Proteasome	Inflammation/Immunology Cancer
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria .

HY-154831

C22-Ceramide (d18:1/22:0) N-Behenoyl-D-erythro-sphingosine; C22-Ceramide; Cer d18:1/22:0	Liposome	Metabolic Disease
C22-Ceramide (d18:1/22:0) (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide (d18:1/22:0) reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes .

HY-N6998

Paederosidic acid 1 Publications Verification	Apoptosis	Cancer
Paederosidic acid is isolated from P.?scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis .

HY-117078

Justicidin A	Apoptosis	Cancer
justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer .

HY-125918

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy	Infection Cancer
Bleomycin A5 (Pingyangmycin) hydrochloride is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 hydrochloride exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 hydrochloride inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 hydrochloride can be used in cancer research .

HY-N11591

Ganoderic acid T	Apoptosis DNA/RNA Synthesis Mitochondrial Metabolism	Cancer
Ganoderic acid T is a lanostane triterpenoid. Ganoderic acid T is isolated from Ganoderma lucidum mycelia. Ganoderic acid T induces *Mitochondria*-mediated Apoptosis and inhibits DNA synthesis. Ganoderic acid T exhibits anticancer activity against cervical cancer, liver cancer and lung cancer .

HY-N0636R

Eriocitrin (Standard) Eriodictyol 7-rutinoside (Standard); Eriodictyol 7-O-rutinoside (Standard)	Reference Standards Apoptosis	Cancer
Eriocitrin (Standard) is the analytical standard of Eriocitrin. This product is intended for research and analytical applications. Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria .

HY-W104819

4-Hydroxyphenylglyoxylate 4-Hydroxyphenylglyoxylic acid; 4-HPGA	Acyltransferase Carnitine Palmitoyltransferase (CPT)	Metabolic Disease
4-Hydroxyphenylglyoxylate (4-Hydroxyphenylglyoxylic acid) is an inhibitor of carnitine palmitoyltransferase I (CPT I). 4-Hydroxyphenylglyoxylate can be used to study sensitivity changes in CPT I of liver mitochondria and fatty acid oxidation by isolated hepatocytes. 4-Hydroxyphenylglyoxylate can inhibits fatty acid oxidation .

HY-139205

BMT-297376	Indoleamine 2,3-Dioxygenase (IDO) Mitochondrial Metabolism	Inflammation/Immunology
BMT-297376 is an optimized derivative of Linrodostat (HY-101560). BMT-297376 inhibits IDO1 and the ubiquinone (Q) site of mitochondrial respiratory chain complex I. BMT-297376 is suitable for tumor immunology-related research .

HY-N11636

Ganoderic acid S	Apoptosis	Cancer
Ganoderic acid S is a positional isomer of ganoderic acids, that can be isolated from the fermented mycelia of Ganoderma lucidum. Ganoderic acid S can induce apoptosis in HeLa cells through the mitochondria pathway .

HY-117682

L-(+)-threo-Chloramphenicol (+)-Chloramphenicol; Dextramycine; Dextromycetin	Antibiotic	Infection
L-(+)-threo-Chloramphenicol ((+)-Chloramphenicol) is the S,S-stereoisomer of Chloramphenicol (HY-B0239). L-(+)-Threo-chloramphenicol inhibits protein synthesis in reticulocytes. L-(+)-threo-Chloramphenicol also inhibits the oxidative activity of isolated mitochondria .

HY-N15640

Filiformin (-)-Filiformin	Bacterial	Infection Inflammation/Immunology Cancer
Filiformin ((-)-Filiformin) is a sesquiterpene compound that can be isolated from Laurencia filiformis forma heteroclada. Filiformin exhibits certain cytotoxicity against P388 and BSC-1 cells. Filiformin has antimicrobial activity against Bacillus subtilis, Trichophyton mentagrophytes and Candida albicans. In addition, Filiformin can inhibit oxygen uptake in isolated rat liver mitochondria at a concentration of 150 μM .

HY-126643

Wedeloside	Mitochondrial Metabolism	Others Cancer
Wedeloside is a diterpenoid amino glycoside isolated from the plant Wedelia asperrima. Wedeloside is capable of inhibiting ADP-stimulated respiration in mitochondria and possesses potential anti-tumor activity. Wedeloside is applicable in drug development and toxicological research .

HY-126775

Xenoclauxin	Mitochondrial Metabolism Endogenous Metabolite	Cancer
Xenoclauxin is a secondary metabolite isolated from certain species of the Penicillium genus, which exhibits an inhibitory effect on the proliferation of tumor cells. Xenoclauxin affects cellular energy metabolism, particularly by inhibiting ATP synthesis in the mitochondria. Xenoclauxin can be used for anti-tumor research .

HY-N11643

Ganoderic acid Mk GA-Mk	Apoptosis Reactive Oxygen Species (ROS) MMP Caspase	Cancer
Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research .

HY-N1338

Royleanone NSC 122417	mTOR Akt	Cancer
Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells .

HY-P3148

Astin B	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species (ROS) JNK Bcl-2 Family Caspase	Metabolic Disease
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

HY-176775

TPP-IOA	Oxidative Phosphorylation Mitochondrial Metabolism Apoptosis	Neurological Disease
TPP-IOA is a cytochrome c peroxidase inhibitor. TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol. TPP-IOA disrupts oxidative phosphorylation in isolated mitochondria. TPP-IOA inhibits cell death in SH-SY5Y cells grown in glucose, but not galactose. TPP-IOA causes mitochondrial depolarization and network fragmentation. TPP-lOA mitigates radiation induced death in mice .

HY-145545

1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE PE(18:0/22:4); 1-Stearoyl-2-Docosatraenoyl-sn-glycero-3-PE	Endogenous Metabolite	Metabolic Disease
1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) and adrenic acid (HY-W013215) at the sn-1 and sn-2 positions, respectively. 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE levels are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus.

HY-W402074

5-Acetamide-Butenolide Butenolide	Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Metabolic Disease
5-Acetamide-Butenolide (Butenolide) is a mycotoxin with pro-oxidant activity, which is found in Fusarium. 5-Acetamide-Butenolide disrupts the mitochondrial membrane potential in primary neonatal rat cardiomyocytes. 5-Acetamide-Butenolide also induces the production of thiobarbituric acid reactive substances (TBARS) in isolated rat myocardial mitochondria. 5-Acetamide-Butenolide increases the production of reactive oxygen species (ROS), decreases the levels of GSH and reduces the viability of HepG2 cells .

HY-N8617

Trijuganone C	DNA/RNA Synthesis Caspase PARP Bcl-2 Family Mitochondrial Metabolism Apoptosis	Cancer
Trijuganone C is a tanshinone-type diterpenoid compound. Trijuganone C can be isolated from the roots of Salvia miltiorrhiza Bunge. Trijuganone C induces chromatin condensation, DNA fragmentation, activation of Caspase-3, -8 and -9, as well as cleavage of PARP. Trijuganone C activates Bid and Bax, leading to loss of mitochondrial membrane potential and inducing the release of cytochrome c from mitochondria into the cytosol. Trijuganone C exerts antiproliferative effects through Apoptosis induction mediated by Mitochondrial dysfunction and Caspase activation. Trijuganone C exhibits significant antiproliferative activity against leukemia cells and colon cancer cells .

HY-N7056R

4'-Hydroxychalcone (Standard)	Reference Standards Proteasome Oxidative Phosphorylation	Inflammation/Immunology Cancer
4'-Hydroxychalcone (Standard) is the analytical standard of 4'-Hydroxychalcone (HY-N7056). This product is intended for research and analytical applications. 4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria .

HY-125778

Cochlioquinone B	Others	Metabolic Disease
Cochlioquinone is a sesquiterpene metabolite originally isolated from C. miyabeanus. It is a phytotoxin that inhibits root growth of finger millet (E. coracana) and rice plants (O. sativa) by 59.9 and 51.7%, respectively, when used at a concentration of 100 ppm.2 Cochlioquinone B inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone reductase from bovine heart mitochondria.

HY-N13352

Bufothionine	Mitochondrial Metabolism STAT JAK Interleukin Related Atg7 Autophagy Pim	Inflammation/Immunology Cancer
Bufothionine is an alkaloid. Bufothionine can be isolated from Cinobufacini. Bufothionine induces *mitochondria*-mediated Apoptosis. Bufothionine significantly reduces serum IL-6 concentration, suppresses p-Stat3 ^tyr705, p-Stat3 ^ser727 and Jak2 expressions. Bufothionine upregulates Atg5, Atg7 and LC3Ⅱ expressions. Bufothionine induces Autophagy. Bufothionine suppresses PIM3 expression. Bufothionine relieves symptoms of H22-tumor-bearing mice and exerts anti-inflammation activity. Bufothionine exerts anti-cancer activities against gastric cancer .

C22-Ceramide (d18:1/22:0) N-Behenoyl-D-erythro-sphingosine; C22-Ceramide; Cer d18:1/22:0	Biochemical Assay Reagents
C22-Ceramide (d18:1/22:0) (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide (d18:1/22:0) reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes .

Cat. No.	Product Name	Target	Research Area

HY-P3148

Astin B	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species (ROS) JNK Bcl-2 Family Caspase	Metabolic Disease
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression .

Cat. No.	Product Name

HY-K0601

JC-1 Mitochondrial Membrane Potential Assay Kit 145+ Cited Publications
MCE JC-1 Mitochondrial Membrane Potential Assay Kit uses JC-1 to detect the mitochondrial membrane potential in variety of cell types, as well as intact tissues and isolated mitochondria.

Eriocitrin 5 Publications Verification Eriodictyol 7-rutinoside; Eriodictyol 7-O-rutinoside	Flavonoids Classification of Application Fields Citrus limon (L.) Burm. F. Flavonones Rutaceae Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Apoptosis
Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria .

Bleomycin A5 1 Publications Verification Pingyangmycin	Structural Classification Natural Products Microorganisms Animals Source Classification	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy
Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research .

4'-Hydroxychalcone 3 Publications Verification	Chalcones Monophenols Flavonoids Classification of Application Fields Leguminosae Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch. Source Classification	Oxidative Phosphorylation Proteasome
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria .

Paederosidic acid 1 Publications Verification	other families Iridoids Classification of Application Fields Terpenoids Paederia scandens (Lour.) Merr. Rubiaceae Plants Disease Research Fields Source Classification Cancer	Apoptosis
Paederosidic acid is isolated from P.?scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis .

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy
Bleomycin A5 (Pingyangmycin) hydrochloride is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 hydrochloride exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 hydrochloride inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 hydrochloride can be used in cancer research .

Ganoderic acid T	Triterpenes Structural Classification Microorganisms Terpenoids Source Classification	Apoptosis DNA/RNA Synthesis Mitochondrial Metabolism
Ganoderic acid T is a lanostane triterpenoid. Ganoderic acid T is isolated from Ganoderma lucidum mycelia. Ganoderic acid T induces *Mitochondria*-mediated Apoptosis and inhibits DNA synthesis. Ganoderic acid T exhibits anticancer activity against cervical cancer, liver cancer and lung cancer .

Eriocitrin (Standard) Eriodictyol 7-rutinoside (Standard); Eriodictyol 7-O-rutinoside (Standard)	Structural Classification Flavonoids Citrus limon (L.) Burm. F. Flavonones Rutaceae Phenols Polyphenols Plants Source Classification	Reference Standards Apoptosis
Eriocitrin (Standard) is the analytical standard of Eriocitrin. This product is intended for research and analytical applications. Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria .

Ganoderic acid S	Triterpenes Microorganisms Terpenoids Source Classification	Apoptosis
Ganoderic acid S is a positional isomer of ganoderic acids, that can be isolated from the fermented mycelia of Ganoderma lucidum. Ganoderic acid S can induce apoptosis in HeLa cells through the mitochondria pathway .

Filiformin (-)-Filiformin	Structural Classification Terpenoids Marine algae Sesquiterpenes Marine natural products Source Classification	Bacterial
Filiformin ((-)-Filiformin) is a sesquiterpene compound that can be isolated from Laurencia filiformis forma heteroclada. Filiformin exhibits certain cytotoxicity against P388 and BSC-1 cells. Filiformin has antimicrobial activity against Bacillus subtilis, Trichophyton mentagrophytes and Candida albicans. In addition, Filiformin can inhibit oxygen uptake in isolated rat liver mitochondria at a concentration of 150 μM .

Wedeloside	Microorganisms Terpenoids Diterpenoids Source Classification	Mitochondrial Metabolism
Wedeloside is a diterpenoid amino glycoside isolated from the plant Wedelia asperrima. Wedeloside is capable of inhibiting ADP-stimulated respiration in mitochondria and possesses potential anti-tumor activity. Wedeloside is applicable in drug development and toxicological research .

Xenoclauxin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Mitochondrial Metabolism Endogenous Metabolite
Xenoclauxin is a secondary metabolite isolated from certain species of the Penicillium genus, which exhibits an inhibitory effect on the proliferation of tumor cells. Xenoclauxin affects cellular energy metabolism, particularly by inhibiting ATP synthesis in the mitochondria. Xenoclauxin can be used for anti-tumor research .

Ganoderic acid Mk GA-Mk	Triterpenes Microorganisms Terpenoids Source Classification	Apoptosis Reactive Oxygen Species (ROS) MMP Caspase
Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research .

Royleanone NSC 122417	Quinones Anthraquinones Labiatae Plants Source Classification Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	mTOR Akt
Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis, also inhibits cell migration potential, inhibits mTOR/PI3/AKT signaling pathway in LNCaP prostate cancer cells .

Cat. No.	Product Name		Classification

HY-145545

1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE PE(18:0/22:4); 1-Stearoyl-2-Docosatraenoyl-sn-glycero-3-PE		Phospholipids
1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) and adrenic acid (HY-W013215) at the sn-1 and sn-2 positions, respectively. 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE levels are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus.

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isolated mitochondria

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