latency-associated peptide

By Targets:	Integrin (1) TGF-beta/Smad (2) TGF-β Receptor (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (3)

Targets Recommended: RXFP Receptor Formyl Peptide Receptor (FPR) Peptide-Drug Conjugates (PDCs) Natriuretic Peptide Receptor (NPR) Connective Peptide CGRP Receptor Amyloid-β

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990667

STX-100	Integrin TGF-beta/Smad	Inflammation/Immunology Cancer
STX-100 is a humanized monoclonal antibody targeting αVβ6 integrin. STX-100 specifically binds αVβ6 integrin, blocks latent TGF-β activation via latency-associated peptide (LAP) interaction prevention, and reduces profibrotic responses. STX-100 can be used for the research of idiopathic pulmonary fibrosis, and cancer .

HY-P3971

H-Leu-Ser-Lys-Leu-OH	TGF-beta/Smad	Inflammation/Immunology
H-Leu-Ser-Lys-Leu-OH (LSYL) is a latency-associated peptide at the amino terminus of LAP, with inhibitory effect on TGF-β1 activation. H-Leu-Ser-Lys-Leu-OH, binding with KRFK (HY-P3970), can block the signal transduction of TGF-β1, and prevent the progression of hepatic damage and fibrosis .

HY-182611

SRI-31277	TGF-β Receptor	Inflammation/Immunology Cancer
SRI-31277 is a thrombospondin 1 (TSP-1) inhibitor with a human target pIC₅₀ of 8.28 nM and in vivo activity, and exhibits a very short plasma half-life with intravenous administration.SRI-31277 inhibits interaction between TSP-1 and the latency-associated peptide (LAP) of latent TGF-β, blocking TSP-1-mediated TGF-β activation.SRI-31277 can be used for the research of multiple myeloma and fibrotic conditions .

HY-182612

SRI-35241	TGF-β Receptor	Cancer
SRI-35241 is a thrombospondin TSP-1 inhibitor with a pIC₅₀ of 8.12 nM against human targets. SRI-35241 inhibits the binding of TSP-1 to latent transforming growth factor-β-associated peptide (LAP) and blocks the activation of TGF-β. SRI-35241 shows a certain time-dependent property, with a plasma half-life of 1.8 h after intravenous administration. SRI-35241 can be used for the research of multiple myeloma and fibrotic diseases .

Cat. No.	Product Name	Target	Research Area

HY-P3971

H-Leu-Ser-Lys-Leu-OH	TGF-beta/Smad	Inflammation/Immunology
H-Leu-Ser-Lys-Leu-OH (LSYL) is a latency-associated peptide at the amino terminus of LAP, with inhibitory effect on TGF-β1 activation. H-Leu-Ser-Lys-Leu-OH, binding with KRFK (HY-P3970), can block the signal transduction of TGF-β1, and prevent the progression of hepatic damage and fibrosis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990667

STX-100	Integrin TGF-beta/Smad	Inflammation/Immunology Cancer
STX-100 is a humanized monoclonal antibody targeting αVβ6 integrin. STX-100 specifically binds αVβ6 integrin, blocks latent TGF-β activation via latency-associated peptide (LAP) interaction prevention, and reduces profibrotic responses. STX-100 can be used for the research of idiopathic pulmonary fibrosis, and cancer .

Species:	Human (9) Mouse (1) Rat (2) Canine (1) Pig (1)
Tag:	His (7) Tag Free (4) Avi (2) Fc (1)
Source:	HEK293 (10) CHO (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70433

	TGF beta 1/TGFB1 LAP Protein, Human (HEK293) 1 Publications Verification Transforming Growth Factor Beta-1; TGF-Beta-1; latency-associated peptide; LAP; TGFB1; TGFB	Human	HEK293
	TGF beta 1/TGFB1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. TGF beta 1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, apoptosis, and can regulate the expression and activation of other growth factors, including interferon gamma and tumor necrosis factor alpha. TGF beta 1/TGFB1 LAP Protein, Human (HEK293) is the recombinant human-derived TGF beta 1/TGFB1 LAP protein, expressed by HEK293 , with tag free. and C33S mutation.

HY-P71056

	TGF beta 1/TGFB1 Protein, Human (Biotinylated, HEK293, N-Avi) Transforming Growth Factor Beta-1; TGF-Beta-1; latency-associated peptide; LAP; TGFB1; TGFB	Human	HEK293
	TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in normal and pathological tissues. TGF beta 1/TGFB1 Protein, Human (Biotinylated, HEK293, N-Avi) is a recombinant protein (A279-S390) produced by HEK293 cells with Avi tag.

HY-P705099

	Latent TGF beta 1/TGFB1 Protein, Human (Biotinylated, C33S, HEK293, Fc-Avi) Transforming Growth Factor Beta-1; TGF-Beta-1; latency-associated peptide; LAP; TGFB1; TGFB	Human	HEK293

HY-P70236

	Latent TGF beta 1/TGFB1 Protein, Human (C33S, HEK293, His) rHuLatent TGF Beta-1-C33S, His; Transforming Growth Factor Beta-1; TGF-Beta-1; latency-associated peptide; LAP; TGFB1; TGFB	Human	HEK293
	Latent TGF beta 1/TGFB1 Protein is a large extracellular matrix protein and an associated ligand of fibrillinmicrofibrils. Latent TGF beta 1/TGFB1 Protein, Human (C33S, HEK293, His) is a recombinant Biotinylated protein (L30-S390) produced by HEK293 cells with His tag.

HY-P70543G

	GMP TGF beta 1/TGFB1 Protein, Human (CHO) 1 Publications Verification Transforming Growth Factor Beta-1; TGF-Beta-1; latency-associated peptide; LAP; TGFB1; TGFB; TGF-β1; TGF beta1; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1	Human	CHO
	TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in normal and pathological tissues. GMP TGF beta 1/TGFB1 Protein, Human (HEK293) is a GMP-grade recombinant protein (A279-S390) produced by CHO cells.

HY-P70543

	TGF beta 1/TGFB1 Protein, Human (HEK293) Maximum Cited Publications 50 Publications Verification Transforming Growth Factor Beta-1; TGF-Beta-1; latency-associated peptide; LAP; TGFB1; TGFB; TGF-β1; TGF beta1; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1	Human	HEK293
	TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in normal and pathological tissues. TGF beta 1/TGFB1 Protein, Human (HEK293) is a recombinant protein (A279-S390) produced by HEK293 cells.

HY-P70648

	TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293) 20+ Cited Publications TGF-beta-1; CED; DPD1; TGFB; TGF-b1; TGFB1; CEDLAP; latency-associated peptide; TGFbeta; TGF-beta 1 protein; transforming growth factor beta-1; TGF-β1; TGF beta1; TGFbeta 1; TGF-beta 1; TGFbeta	Rat;Mouse	HEK293
	TGF beta 1/TGFB1 Protein belongs to the TGF-β superfamily. TGF beta 1/TGFB1 Protein plays a key role in various physiological and pathological processes such as cell growth, differentiation, apoptosis, immune regulation, and extracellular matrix formation. TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293) is a recombinant TGF beta 1/TGFB1 Protein expressed by HEK293 without a tag.

HY-P700150AF

	Animal-Free TGF beta 1/TGFB1 Protein, Human (His) Transforming Growth Factor beta-1; TGF-beta-1; latency-associated peptide; LAP; TGFB1; TGFB; TGF-β1; TGF beta1; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1	Human	E. coli
	TGF beta 1/TGFB1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. TGF beta 1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, apoptosis, and can regulate the expression and activation of other growth factors, including interferon gamma and tumor necrosis factor alpha. Animal-Free TGF beta 1/TGFB1 Protein, Human (His) is the recombinant human-derived animal-FreeTGF beta 1/TGFB1 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P700251AF

	Animal-Free TGF beta 1/TGFB1 Protein, Pig (His) Differentiation inhibiting factor; Cartilage-inducing factor	Pig	E. coli
	TGFB1 proprotein is the precursor of latency-associated peptide (LAP) and active transforming growth factor Beta-1 (TGF-β-1) chain, which maintains TGF-β-1 latency in the extracellular matrix. TGFB1 binds non-covalently to TGF-β-1 and regulates its activation through interactions with “environmental molecules” (LTBP1, LRRC32/GARP, LRRC33/NRROS). Animal-Free TGF beta 1/TGFB1 Protein, Pig (His) is the recombinant pig-derived animal-FreeTGF beta 1/TGFB1 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P73617

	TGF beta 1/TGFB1 Protein, Canine (HEK293, His) Transforming growth factor beta-1 proprotein; LAP; TGF-beta-1; TGFB1	Canine	HEK293
	TGFB1 proprotein is the precursor of latency-associated peptide (LAP) and active transforming growth factor Beta-1 (TGF-β-1) chain, which maintains TGF-β-1 latency in the extracellular matrix. TGFB1 binds non-covalently to TGF-β-1 and interacts with “environmental molecules” (LTBP1, LRRC32/GARP, LRRC33/NRROS) to regulate TGF-β-1 activation. TGF beta 1/TGFB1 Protein, Canine (HEK293, His) is the recombinant canine-derived TGF beta 1/TGFB1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P73615

	Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, His) 1 Publications Verification Transforming growth factor beta-1 proprotein; LAP; TGF-beta-1; TGFB1	Rat	HEK293
	Latent TGF beta 1 (latent TGFB1) is the inactive form of TGF-B1. Latent TGF beta 1 associates with the extracellular matrix (ECM) via LTBP. LTBPs are components of the ECM, so that the proteolytic cleavage of LTBP can lead to the release of latent TGF-beta 1 from the matrix. Besides, the proteolytic cleavage and liberation of active TGFB1 is performed by BMP-1, by a variety of matrix metalloproteinases (MMPs). Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, His) is the recombinant rat-derived Latent TGF beta 1/TGFB1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P73616

	TGF beta 1/TGFB1 LAP Protein, Human (HEK293, His) 1 Publications Verification Transforming growth factor beta-1 proprotein; LAP; TGF-beta-1; TGFB1	Human	HEK293
	TGF beta 1/TGFB1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. TGF beta 1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, apoptosis, and can regulate the expression and activation of other growth factors, including interferon gamma and tumor necrosis factor alpha. TGF beta 1/TGFB1 LAP Protein, Human (HEK293, His) is the recombinant human-derived TGF beta 1/TGFB1 Latency-associated peptide protein, expressed by HEK293 , with C-10*His labeled tag and C33S mutation.

HY-P73426

	Latent TGF beta 1/TGFB1 Protein, Human (HEK293, His) Transforming growth factor beta-1 proprotein; LAP; TGF-beta-1; TGFB1	Human	HEK293
	TGF beta 1/TGFB1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. TGF beta 1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, apoptosis, and can regulate the expression and activation of other growth factors, including interferon gamma and tumor necrosis factor alpha. Latent TGF beta 1/TGFB1 Protein, Human (HEK293, His) is the recombinant human-derived Latent TGF beta 1/TGFB1 protein, expressed by HEK293 , with C-His labeled tag.

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Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (2) ICC/IF (3) IP (2) WB (3) ELISA (3)
Isotype:	IgG (1) IgG/Kappa (1) IgG2b (1)
Conjugation:	Non-conjugated (3) Biotin (2)
Clonality:	Monoclonal (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86476

	TGF beta 1 Antibody (YA6168) Transforming growth factor beta-1; TGF-beta-1; [Cleaved into: latency-associated peptide; LAP; ]	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	TGF beta 1 Antibody (YA6168) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TGF beta 1.

HY-P85823

	TGF beta 1 Antibody (YA5515) Transforming growth factor beta-1; TGF-beta-1; [Cleaved into: latency-associated peptide; LAP; ]	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	TGF beta 1 Antibody (YA5515) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TGF beta 1.

HY-P86472

	TGF beta 1/TGF beta 3 Antibody (YA6164) Transforming growth factor beta-1 proprotein; latency-associated peptide; LAP; Transforming growth factor beta-1; TGF-beta-1; Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3; TGF-beta-3;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	TGF beta 1/TGF beta 3 Antibody (YA6164) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TGF beta 1/TGF beta 3.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

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