1439902-67-6
1439902-67-6
Chemical Structure
Biological Activity: STX-100 (BG00011) is a humanized monoclonal antibody targeting αVβ6 integrin. STX-100 specifically binds αVβ6 integrin, blocks latent TGF-β activation via latency-associated peptide (LAP) interaction prevention, and reduces profibrotic responses. STX-100 can be used for the research of idiopathic pulmonary fibrosis, and cancer[1][2][3][4][5].
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STX-100 | 99.99% | STX-100 (BG00011) is a humanized monoclonal antibody targeting αVβ6 integrin. STX-100 specifically binds αVβ6 integrin, blocks latent TGF-β activation via latency-associated peptide (LAP) interaction prevention, and reduces profibrotic responses. STX-100 can be used for the research of idiopathic pulmonary fibrosis, and cancer. | ||||||||||||||||||||
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References
- [1]. Crunkhorn S. Deal watch: Biogen acquires Stromedix to pursue novel fibrosis therapy. Nat Rev Drug Discov. 2012 Mar 30;11(4):260. [Content Brief]
- [2]. Lo DJ, et al. Inhibition of αvβ6 promotes acute renal allograft rejection in nonhuman primates. Am J Transplant. 2013;13(12):3085-3093. [Content Brief]
- [3]. Wesam Elhawabri. REGULATION OF TGF-β1–INDUCED EPITHELIAL–MESENCHYMAL TRANSITION BY INTEGRIN INHIBITION.
- [4]. Sylvers PH, et al. Mitigation of harmful algal blooms caused by Alexandrium catenella and reduction in saxitoxin accumulation in bivalves using cultivable seaweeds. Harmful Algae. 2021;105:102056. [Content Brief]
- [5]. Raghu G, et al. Randomized Phase IIa Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 Nov 1;206(9):1166-1168. [Content Brief]
