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Results for "

multidrug-resistant escherichia coli

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-164036
    Lolamicin

    		Antibiotic Bacterial Infection
    Lolamicin is an orally effective inhibitor that specifically targets the Gram-negative bacteria lipoprotein transport system LolCDE complex. It selectively inhibits the transmembrane transport of outer membrane lipoproteins by competitively binding to lipoprotein binding sites. Lolamicin destroys the integrity of the bacterial outer membrane, leading to cell death, and has both bactericidal and antibacterial activity. It has significant effects on multidrug-resistant Enterobacteriaceae pathogens (such as Escherichia coli and Klebsiella pneumoniae). Lolamicin can be used to inhibit the study of acute pneumonia, sepsis and other infections caused by Gram-negative bacteria .
    Lolamicin
  • HY-P10233A
    SAAP 148 TFA

    		Bacterial Infection
    SAAP 148 TFA is a synthetic antimicrobial peptide (bacteria) that interacts with and disrupts the lipid bilayer of bacterial cytoplasmic membranes, thereby inducing changes in membrane permeability and bacterial death. SAAP 148 TFA kills drug-resistant, multidrug-resistant and persister bacterial strains, inhibits biofilm formation, eliminates established biofilms, and blocks bacterial colonization on implant surfaces. SAAP 148 TFA retains its activity after modification or immobilization, exhibits variable cytotoxicity in different human cell models, and shows reduced efficacy in protein-rich environments. SAAP 148 TFA can be used in infection-related research .
    SAAP 148 TFA
  • HY-124679
    DS86760016

    		Bacterial Infection
    DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. DS86760016 inhibits LeuRS enzymes from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, with IC50s of 0.38, 0.62, and 0.16 μM, respectively .
    DS86760016
  • HY-Y1826
    IITR01324

    		Bacterial Antibiotic Infection
    IITR01324 is an antimicrobial agent. IITR01324 has antimicrobial activity against Escherichia coli (MIC = 3.58 mg/L) and other Gram-negative bacteria (Shigella flexneri: MIC = 3.58 mg/L; Cronobacter sakazakii: MIC = 28.63 mg/L). IITR01324 exerts its antimicrobial activity by destroying bacterial DNA after activation of intracellular reductases. IITR01324 can be used to study the development of new antimicrobial drugs, especially against multidrug-resistant (MDR) pathogens .
    IITR01324
  • HY-142545
    Antibacterial agent 68

    		Bacterial Infection
    Antibacterial agent 68 (compound 4d) is an antibacterial agent against drug-resistant Escherichia coli. Antibacterial agent 68 has low cytotoxicity and exerts strong antibacterial activities against multidrug-resistant Escherichia coli at low concentrations as 0.007 mM .
    Antibacterial agent 68
  • HY-124679A
    (R)-DS86760016

    		Bacterial Others
    (R)-DS86760016 is the R-enantiomer of DS86760016 (HY-124679). DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa .
    (R)-DS86760016
  • HY-107120
    CB-182804

    		Drug Derivative Antibiotic Bacterial Infection
    CB-182804, Polymyxin B (HY-149179) analogue, is a polypeptide antibiotic. CB-182804 has inhibitory activity against all Gram-negative pathogenic bacteria, including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa with MIC50 values of 2 μg/mL. CB-182804 is mainly used for the research on refractory infections caused by multidrug-resistant (MDR) Gram-negative bacteria .
    CB-182804
  • HY-130004
    MsbA-IN-6

    		Antibiotic Bacterial Infection
    MsbA-IN-6 is a potent inhibitor of MsbA. MsbA-IN-6 is an antibiotic. Gram-negative ATP-binding cassette (ABC) transporter MsbA, an essential inner membrane protein, transports lipopolysaccharide from the inner leaflet to the periplasmic face of the inner membrane. MsbA-IN-6 kills Escherichia coli through inhibition of its ATPase and transport activity, with no loss of activity against clinical multidrug-resistant strains .
    MsbA-IN-6
  • HY-181100
    DHFR-IN-26

    		Dihydrofolate reductase (DHFR) Bacterial Infection
    DHFR-IN-26 is an Escherichia coli dihydrofolate reductase (ecDHFR) inhibitor with an IC50 of 0.75 nM. DHFR-IN-26 exerts broad-spectrum antibacterial activity. DHFR-IN-26 disrupts folate metabolism, nucleotide synthesis, and bacterial amino acid metabolic pathways. DHFR-IN-26 disrupts bacterial inner membranes, inhibited biofilm formation, and attenuated phage-related processes. DHFR-IN-26 shows lower toxicity to non-cancerous cells. DHFR-IN-26 can be used for the research of bacterial infections (including infections caused by methicillin-resistant Staphylococcus aureus, multidrug-resistant Escherichia coli, multidrug-resistant Pseudomonas aeruginosa, and lysogenic bacteria) .
    DHFR-IN-26
  • HY-Y1826R
    IITR01324 (Standard)

    		Reference Standards Bacterial Antibiotic Infection
    IITR01324 (Standard) is the analytical standard of IITR01324. This product is intended for research and analytical applications. IITR01324 is an antimicrobial agent. IITR01324 has antimicrobial activity against Escherichia coli (MIC=3.58 mg/L) and other Gram-negative bacteria (Shigella flexneri: MIC=3.58 mg/L; Cronobacter sakazakii: MIC=28.63 mg/L). IITR01324 exerts its antimicrobial activity by destroying bacterial DNA after activation of intracellular reductases. IITR01324 can be used to study the development of new antimicrobial drugs, especially against multidrug-resistant (MDR) pathogens .
    IITR01324 (Standard)
  • HY-183702
    BDM91531

    		Antibiotic Bacterial Infection
    BDM91531 is a AcrB inhibitor with an EC50 of 0.16 μM against E. coli. BDM91531 acts as an antibiotic potentiator to restore the sensitivity of wild-type Escherichia coli to multiple AcrB substrate antibiotics. BDM91531 exhibits antibacterial activity. BDM91531 can be used in the research of bacterial infections .
    BDM91531

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