1853176-89-2
Chemical Structure
DS86760016
- CAS No.: 1853176-89-2
- Formula:C9H11BClNO4
- Molecular Weight:243.45
IUPAC Name: (S)-3-(aminomethyl)-[1,3]dioxolo[4',5':5,6]benzo[1,2-c][1,2]oxaborol-1(3H)-ol hydrochloride
InChIKey: FYHCZFHPLJMBAX-OGFXRTJISA-N
SMILES: OB(O1)C(C(OCO2)=C2C=C3)=C3[C@H]1CN.Cl
Biological Activity: DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. DS86760016 inhibits LeuRS enzymes from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, with IC50s of 0.38, 0.62, and 0.16 μM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DS86760016 | 99.25% | DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. DS86760016 inhibits LeuRS enzymes from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, with IC50s of 0.38, 0.62, and 0.16 μM, respectively. | ||||||||||||||||||||
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- [1]. Purnapatre KP, et al. In Vitro and In Vivo Activities of DS86760016, a Novel Leucyl-tRNA Synthetase Inhibitor for Gram-Negative Pathogens. Antimicrob Agents Chemother. 2018;62(4):e01987-17. Published 2018 Mar 27. [Content Brief]
- [2]. Kumar M, et al. DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2019;63(4):e02122-18. Published 2019 Mar 27. [Content Brief]
Keywords
