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Results for "

muscle regeneration

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Amine N-methyltransferase (1) Apoptosis (1) Calcium Channel (2) Casein Kinase (2) DNA/RNA Synthesis (2) Endogenous Metabolite (4) Exosomes (3) Furin (1) Interleukin Related (1) MicroRNA (1) MMP (1) mRNA (1) Notch (1) PAI-1 (1) PIN1 (1) Prostaglandin Receptor (2) REV-ERB (1) Ser/Thr Protease (1) TNF Receptor (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Inflammation/Immunology (5) Metabolic Disease (7) Neurological Disease (2)
Oligonucleotides:	Nucleotide Analogs (3) mRNA (1)

15

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6

Natural
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4

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Guanosine-5'-triphosphate disodium salt Maximum Cited Publications 8 Publications Verification 5'-GTP disodium salt	Exosomes Endogenous Metabolite MicroRNA	Metabolic Disease
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

NNMTi Maximum Cited Publications 10 Publications Verification	Amine N-methyltransferase	Metabolic Disease
NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC₅₀=1.2 μM) and selectively binds to the NNMT substrate-binding site residues . NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice .

Guanosine 5'-triphosphate trisodium 5 Publications Verification 5'-GTP trisodium	Exosomes Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

Guanosine 5'-triphosphate trisodium salt hydrate Maximum Cited Publications 8 Publications Verification 5'-GTP trisodium salt hydrate	Exosomes Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Guanosine 5'-triphosphate (5'-GTP) trisodium salt hydrate is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt hydrate can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt hydrate holds promise for research in biosynthesis and skeletal muscle regeneration .

Sodium creatine phosphate dibasic tetrahydrate 3 Publications Verification Creatine phosphate disodium tetrahydrate; Creatinephosphoric acid disodium tetrahydrate	Endogenous Metabolite	Metabolic Disease
Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

Levobunolol hydrochloride 1 Publications Verification l-Bunolol hydrochloride	Adrenergic Receptor Calcium Channel Casein Kinase	Cardiovascular Disease
Levobunolol (l-Bunolol) hydrochloride is a non-selective β-adrenergic antagonist and vasodilator. By blocking calcium ion influx and reducing the sensitivity of vascular smooth muscle to calcium, Levobunolol hydrochloride effectively dilates the ciliary arteries and increases ocular blood flow, so it is widely used in research on glaucoma and ocular hypertension. Levobunolol hydrochloride inhibits the β-receptor signaling pathway and the expression of related proliferation markers (such as CK3, CK14, CK19, Ki67) in corneal cells. In rabbit models, Levobunolol hydrochloride not only does not inhibit corneal epithelial regeneration, but also accelerates the healing of mechanical injury without adverse effects. Levobunolol hydrochloride also inhibits histamine-induced vasoconstriction and intracellular calcium elevation, exhibiting unique vascular regulatory activity. Levobunolol hydrochloride protects ocular blood flow and promotes corneal repair .

Tetrahydroxymethoxychalcone	Others	Others
Tetrahydroxymethoxychalcone is a phenolic and flavonoid compound. Tetrahydroxymethoxychalcone is found to enhance myoblast proliferation and differentiation. Tetrahydroxymethoxychalcone plays important roles in myogenesis and muscle regeneration .

Pizuglanstat TAS-205 free base	Prostaglandin Receptor	Metabolic Disease Inflammation/Immunology
Pizuglanstat (Compound 3; TAS-205 free base) is an orally active prostaglandin D synthase inhibitor with an IC₅₀ of 76 nM for human hematopoietic prostaglandin D synthase. Pizuglanstat inhibits the synthesis of PGD₂. Pizuglanstat improves experimental allergic rhinitis. Pizuglanstat can be used in the study of muscle regenerative diseases such as muscular dystrophy .

Pizuglanstat hydrate TAS-205	Prostaglandin Receptor	Metabolic Disease Inflammation/Immunology
Pizuglanstat hydrate (Compound 3; TAS-205) is an orally active prostaglandin D synthase inhibitor with an IC₅₀ of 76 nM for human hematopoietic prostaglandin D synthase. Pizuglanstat hydrate inhibits the synthesis of PGD₂. Pizuglanstat hydrate improves experimental allergic rhinitis. Pizuglanstat hydrate can be used in the study of muscle regenerative diseases such as muscular dystrophy .

Human FGF6 mRNA	mRNA	Cancer
Human FGF6 mRNA encodes the human fibroblast growth factor 6 (FGF6) protein, a member of the fibroblast growth factor (FGF) family. FGF6 may play an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is also required for normal muscle regeneration.

Levobunolol l-Bunolol	Adrenergic Receptor Casein Kinase Calcium Channel	Others
Levobunolol (l-Bunolol) is a non-selective β-adrenergic antagonist and vasodilator. By blocking calcium ion influx and reducing the sensitivity of vascular smooth muscle to calcium, Levobunolol effectively dilates the ciliary arteries and increases ocular blood flow, so it is widely used in research on glaucoma and ocular hypertension. Levobunolol inhibits the β-receptor signaling pathway and the expression of related proliferation markers (such as CK3, CK14, CK19, Ki67) in corneal cells. In rabbit models, Levobunolol not only does not inhibit corneal epithelial regeneration, but also accelerates the healing of mechanical injury without adverse effects. Levobunolol also inhibits histamine-induced vasoconstriction and intracellular calcium elevation, exhibiting unique vascular regulatory activity. Levobunolol protects ocular blood flow and promotes corneal repair .

Benzo-17R-RvD2 Benzo-17R-Resolvin D2	TNF Receptor Interleukin Related	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Benzo-17R-RvD2 (Benzo-17R-Resolvin D2) is a benzo-containing analog of RvD2 (HY-121636). Benzo-17R-RvD2 enhances human macrophage efferocytosis, limits neutrophil infiltration, reduces TNF-α, and increases IL-1 receptor antagonist in peritonitis. Benzo-17R-RvD2 promotes E. coli killing by human leukocytes and reduces neutrophil swarm area without compromising anti-Candida activity. Benzo-17R-RvD2 activates the human-RvD2 receptor with an EC₅₀ ∼1.5 nM. Benzo-17R-RvD2 can be used in research on inflammation-associated diseases such as cardiovascular disease, cancer, neuroinflammation, pain, and muscle regeneration .

L-Balenine	PIN1	Inflammation/Immunology
L-Balenine is an orally active Pin1 inhibitor and intracellular pH buffer. L-Balenine enhances the phagocytic activity of macrophages, and promotes the expression of pro-inflammatory and anti-inflammatory cytokines during muscle degeneration. L-Balenine also upregulates the expression of myogenic marker genes associated with regeneration, thereby effectively driving skeletal muscle regeneration. L-Balenine can be widely used in studies related to skeletal muscle injury and its repair mechanisms .

BE2012	REV-ERB	Neurological Disease
BE2012, SR8278 (HY-14415) derivative, is a potent and selective REV-ERBα/β Antagonist with EC₅₀ values of 0.285 and 0.346 μM. BE2012 binds to the ligand-binding domain (LBD) of REV-ERB, preventing the receptor from recruiting co-inhibitory factors and thereby releasing the transcriptional repression on downstream target genes. BE2012 can upregulate the expression of myogenic transcription factors Myf5 and Myod, promoting muscle regeneration and repair in acute muscle injury micemodels .

TM5614 sodium	PAI-1 Ser/Thr Protease Furin MMP Notch Apoptosis	Inflammation/Immunology Cancer
TM5614 sodium is an orally active and specific PAI-1 inhibitor with an IC₅₀ of <6.95 μM. TM5614 sodium blocks the interaction between PAI-1 and serine proteases or LRP-1, and enhances plasmin generation. TM5614 sodium restores macrophage efferocytosis and promotes macrophage polarization. TM5614 sodium alleviates PAI-1-mediated inhibition of Furin, promotes MT1-MMP maturation, activates the NOTCH1 signaling pathway, inhibits proliferation and induces apoptosis. TM5614 sodium promotes skeletal muscle regeneration and alleviates inflammation in a mouse model of skeletal muscle injury. TM5614 sodium can be used in research on skeletal muscle injury-induced inflammation and chronic myeloid leukemia .

Cat. No.	Product Name		Classification

Guanosine-5'-triphosphate disodium salt Maximum Cited Publications 8 Publications Verification 5'-GTP disodium salt		Nucleotide Analogs
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

Guanosine 5'-triphosphate trisodium 5 Publications Verification 5'-GTP trisodium		Nucleotide Analogs
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration .

Guanosine 5'-triphosphate trisodium salt hydrate Maximum Cited Publications 8 Publications Verification 5'-GTP trisodium salt hydrate		Nucleotide Analogs
Guanosine 5'-triphosphate (5'-GTP) trisodium salt hydrate is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt hydrate can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt hydrate holds promise for research in biosynthesis and skeletal muscle regeneration .

Human FGF6 mRNA		mRNA
Human FGF6 mRNA encodes the human fibroblast growth factor 6 (FGF6) protein, a member of the fibroblast growth factor (FGF) family. FGF6 may play an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is also required for normal muscle regeneration.

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