42464-96-0
42464-96-0
Chemical Structure
NNMTi
- CAS No.: 42464-96-0
- Formula:C10H11IN2
- Molecular Weight:286.11
IUPAC Name: 5-amino-1-methylquinolin-1-ium iodide
InChIKey: JPEZFBFIRRAFNR-UHFFFAOYSA-N
SMILES: C[N+]1=C2C=CC=C(N)C2=CC=C1.[I-]
Biological Activity: NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues[2]. NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NNMTi | 99.82% | NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues. NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-W001604Quinolin-5-amine -
Similarity Score 0.79
HY-W0125661,5-Naphthalenediamine -
Similarity Score 0.79
HY-W0073178-Aminoquinoline -
Similarity Score 0.79
HY-W008059Isoquinolin-4-amine -
Similarity Score 0.78
HY-W000494Isoquinolin-1-amine -
Similarity Score 0.78
HY-W1006754NNMT-IN-7 -
Similarity Score 0.77
HY-W017239R4-Aminoquinaldine (Standard) -
Similarity Score 0.76
HY-I02598-Amino-2-naphthol -
Similarity Score 0.76
HY-W0075242-Aminoquinoline -
Explore the MedChemAI to find more analogs
References
- [1]. Harshini Neelakantan, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492. [Content Brief]
- [2]. Harshini Neelakantan, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem [Content Brief]
