58213-75-5
Chemical Structure
BD-AcAc2
Synonym(s): R,S-1,3-Butanediol acetoacetate diester
- CAS No.: 58213-75-5
- Formula:C12H18O6
- Molecular Weight:258.27
InChIKey: MDOKNTXSIGQKCJ-UHFFFAOYSA-N
SMILES: O=C(CC(C)=O)OCCC(C)OC(CC(C)=O)=O
Biological Activity: BD-AcAc2 (R,S-1,3-Butanediol acetoacetate diester) is an orally active, CNS-penetrant antiepileptic agent. BD-AcAc2 inhibits NF-κB, NLRP3 inflammasome, caspase-1/3, pyroptosis, apoptosis, and enhances autophagy. BD-AcAc2 exhibits antioxidant activity by modulating ROS, MDA, SOD, and GSH levels, and alleviates oxidative stress. BD-AcAc2 mitigates chronic colitis, counteracts Dextran Sodium Sulfate (DSS)-induced pathology, protects against central nervous system oxygen toxicity and acute lung injury, and exhibits anti-seizure efficacy. BD-AcAc2 can be used for the research of colitis, sarcopenia, acute lung injury, seizure, and obesity[1][2][3][4][5].
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BD-AcAc2 | BD-AcAc2 (R,S-1,3-Butanediol acetoacetate diester) is an orally active, CNS-penetrant antiepileptic agent. BD-AcAc2 inhibits NF-κB, NLRP3 inflammasome, caspase-1/3, pyroptosis, apoptosis, and enhances autophagy. BD-AcAc2 exhibits antioxidant activity by modulating ROS, MDA, SOD, and GSH levels, and alleviates oxidative stress. BD-AcAc2 mitigates chronic colitis, counteracts Dextran Sodium Sulfate (DSS)-induced pathology, protects against central nervous system oxygen toxicity and acute lung injury, and exhibits anti-seizure efficacy. BD-AcAc2 can be used for the research of colitis, sarcopenia, acute lung injury, seizure, and obesity. | |||||||||||||||||||||
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- [1]. Saber S, Alamri MMS, Alfaifi J, et al.. (R,R)-BD-AcAc2 Mitigates Chronic Colitis in Rats: A Promising Multi-Pronged Approach Modulating Inflammasome Activity, Autophagy, and Pyroptosis. Pharmaceuticals (Basel, Switzerland). 2023 Jul 03;16(7):953. [Content Brief]
- [2]. Roberts BM, et al. Effects of an exogenous ketone ester using multi-omics in skeletal muscle of aging C57BL/6J male mice. Front Nutr. 2022 Nov 15;9:1041026. [Content Brief]
- [3]. Yi H, Yu S, Zhang Y, et al.. Preventive effects of ketone ester BD-AcAc on central nervous system oxygen toxicity and concomitant acute lung injury. Diving and hyperbaric medicine. 2018 Dec 24;48(4):235-240. [Content Brief]
- [4]. Viggiano A, Pilla R, Arnold P, et al.. Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure. Brain research. 2015 Aug 27;1618:50-4. [Content Brief]
- [5]. Davis RAH, Deemer SE, Bergeron JM, et al.. Dietary R, S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Feb;33(2):2409-2421. [Content Brief]
Keywords
