Search Result

Results for "

myosin heavy chain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Myosin (3) ATP Synthase (1) Calcium Channel (1) E1/E2/E3 Enzyme (1) nAChR (1) NAMPT (1) Potassium Channel (2) Reference Standards (2) RUNX (1) Thyroid Hormone Receptor (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (7) Endocrinology (2) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Antibodies

Targets Recommended: Myosin Branched Chain Amino Acid Transaminase (BCAT) ELOVL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-159821

Ulacamten CK-4021586; CK-586	Myosin	Cardiovascular Disease
Ulacamten (CK-4021586; CK-586) is an orally active cardiac myosin inhibitor and an inhibitor of the double-headed cardiac heavy meromyosin (HMM)ATPase (excluding single-headed myosin subfragment-1), with an EC₅₀ of 2.9 μM. Ulacamten regulates cardiac myosin, reduces excessive myocardial contractility, and alleviates left ventricular outflow tract obstruction. Ulacamten increases the left ventricular short-axis systolic internal diameter, inhibits dobutamine-induced exacerbation of obstruction, and exerts only a mild reducing effect on left ventricular systolic function. Ulacamten also inhibits the fractional shortening of the short axis without altering calcium transients. Ulacamten shows good safety and tolerability in purpose-bred cats with naturally occurring obstructive hypertrophic cardiomyopathy .

HY-149662

TMDJ-035	Calcium Channel ATP Synthase Myosin	Cardiovascular Disease
TMDJ-035 is a high-affinity, selective RyR2 inhibitor with an EC₅₀ of 0.0130 μM. TMDJ-035 reduces RyR2 protein expression without affecting action potential-induced Ca ²⁺ transients. TMDJ-035 decreases ATP content and intracellular Ca ²⁺ levels. TMDJ-035 inhibits arrhythmias in a CPVT mouse model carrying mutant RyR2s. TMDJ-035 has no effect on electrocardiogram parameters or cardiac systolic function. TMDJ-035 exacerbates heart failure in mouse myocardial infarction models and hypoxic cardiomyocytes by altering cardiac function, causing tissue damage, promoting inflammatory infiltration, collagen deposition, and changes in *Myosin* heavy chain/actin expression. TMDJ-035 can be used in studies related to heart failure, catecholaminergic polymorphic ventricular tachycardia, and arrhythmias .

HY-126236

3,5-Diiodothyropropionic acid 1 Publications Verification	Thyroid Hormone Receptor	Cardiovascular Disease Endocrinology
3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with K_a of 2.40 and 4.06 M ^-1 for TRα1 and TRβ1, respectively. 3,5-Diiodothyropropionic acid promotes angiogenesis in 3-D human dermal microvascular endothelial cell sprouting assay. 3,5-Diiodothyropropionic acid prevents myocardial arteriolar loss in thyroidectomized rats and enhances cardiac energy-generating capacity in postinfarction heart failure rats. 3,5-Diiodothyropropionic can be used in studies related to angiogenesis and heart failure .

HY-B0570

Decamethonium Bromide 1 Publications Verification	nAChR	Neurological Disease
Decamethonium Bromide is an acetylcholine receptor inhibitor and muscle relaxant. Decamethonium Bromide first induces depolarization of skeletal muscles, and then binds to postsynaptic acetylcholine receptors to induce persistent paralysis .\n

HY-102052

DCEBIO	Potassium Channel	Metabolic Disease
DCEBIO is a small/medium conductance calcium-activated potassium (SK_Ca/IK_Ca) channel opener and primary neuron signal blocker. It hyperpolarizes the membrane potential of C2C12 myoblasts by activating IK_Ca channels, thereby promoting myogenic differentiation. The specific biological activity of DCEBIO is manifested in increased myotube formation, enhanced myosin heavy chain II protein levels and myogenin mRNA levels. DCEBIO can be applied in the field of muscle research, especially in muscle-related degenerative diseases such as sarcopenia .

HY-125966

AI-4-57	RUNX	Cancer
AI-4-57 is an allosteric inhibitor for CBFβ SMMHC-RUNX1 (core binding factor β and the smooth-muscle myosin heavy chain) interaction with an IC₅₀ of 22 μM .

HY-126236R

3,5-Diiodothyropropionic acid (Standard)	Thyroid Hormone Receptor Reference Standards	Cardiovascular Disease Endocrinology
3,5-Diiodothyropropionic acid (Standard) is the analytical standard of 3,5-Diiodothyropropionic acid. This product is intended for research and analytical applications. 3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with K_a of 2.40 and 4.06 M ^-1 for TRα1 and TRβ1, respectively. 3,5-Diiodothyropropionic acid promotes angiogenesis in 3-D human dermal microvascular endothelial cell sprouting assay. 3,5-Diiodothyropropionic acid prevents myocardial arteriolar loss in thyroidectomized rats and enhances cardiac energy-generating capacity in postinfarction heart failure rats. 3,5-Diiodothyropropionic can be used in studies related to angiogenesis and heart failure .

HY-P11373

α-Myosin (614-643)	Myosin	Cardiovascular Disease Inflammation/Immunology
α-Myosin (614-643) is a segment of polypeptide of the heavy chain of cardiac α-myosin. α-Myosin has a strong ability to induce autoimmune myocarditis .

HY-182062

NAMPT activator-9	NAMPT E1/E2/E3 Enzyme	Neurological Disease
NAMPT activator-9 (Compound DIPM) is an allosteric, non-competitive NAMPT activator, with an EC₅₀ of 3.366 μM against hNAMPT. NAMPT activator-9 enhances the enzymatic activity of NAMPT via an allosteric, non-competitive mechanism. NAMPT activator-9 increases intracellular NAD ⁺ levels. NAMPT activator-9 restores myotube diameter and reduces the expression of atrophy markers Atrogin-1 and MuRF1. NAMPT activator-9 is applicable to research related to muscle atrophy .

HY-102052R

DCEBIO (Standard)	Reference Standards Potassium Channel	Metabolic Disease
DCEBIO (Standard) is the analytical standard of DCEBIO (HY-102052). This product is intended for research and analytical applications. DCEBIO is a small/medium conductance calcium-activated potassium (SKCa/IKCa) channel opener and primary neuron signal blocker. It hyperpolarizes the membrane potential of C2C12 myoblasts by activating IKCa channels, thereby promoting myogenic differentiation. The specific biological activity of DCEBIO is manifested in increased myotube formation, enhanced myosin heavy chain II protein levels and myogenin mRNA levels. DCEBIO can be applied in the field of muscle research, especially in muscle-related degenerative diseases such as sarcopenia .

Cat. No.	Product Name	Target	Research Area

HY-P2464

Myosin H Chain Fragment, mouse 3 Publications Verification	Peptides	Inflammation/Immunology
Myosin H Chain Fragment, mouse is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model .

HY-P10554

Myhc-α(334–352)	Peptides	Cardiovascular Disease Others Inflammation/Immunology
Myhc-α(334–352) is a sequence fragment of amino acid residues 334 to 352 of cardiac myosin heavy chain α. Myhc-α(334–352) is an immunodominant epitope that can induce autoimmune reactions in A/J mice, leading to the occurrence of myocarditis. Myhc-α(334–352) can be used to study the autoimmune pathways of myocarditis and dilated cardiomyopathy .

HY-P2464A

Myosin H Chain Fragment, mouse acetate	Peptides	Cardiovascular Disease
Myosin H Chain Fragment, mouse acetate salt is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model .

HY-P11373

α-Myosin (614-643)	Myosin	Cardiovascular Disease Inflammation/Immunology
α-Myosin (614-643) is a segment of polypeptide of the heavy chain of cardiac α-myosin. α-Myosin has a strong ability to induce autoimmune myocarditis .

Host:	Mouse (3) Rabbit (8)
Reactivity:	Human (11) FruitFly (1) Rat (8) Mouse (11) Nematode (1)
Application:	IHC-P (8) ICC/IF (3) IF-Tissue (3) IP (2) IHC-F (1) WB (8) ELISA (2)
Isotype:	IgG (8) IgG1 (2)
Conjugation:	Non-conjugated (11)
Clonality:	Monoclonal (10) Recombinant (7)
Modification:	Unmodified (10)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83455

	Myosin heavy chain Antibody (YA3200) MYH6; MYHC; MYHCA; MYHCB; myosin heavy chain 6; myosin heavy chain; myosin-6; myosin heavy chain; cardiac muscle alpha isoform	WB, IHC-P	Human, Mouse, Rat
	Myosin heavy chain Antibody (YA3200) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myosin heavy chain.

HY-P85963

	Myosin Heavy Chain Smooth Muscle Antibody (YA5655) myosin-11; myosin heavy chain 11; myosin heavy chain, smooth muscle isoform; SMMHC;	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Myosin Heavy Chain Smooth Muscle Antibody (YA5655) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Myosin Heavy Chain Smooth Muscle.

HY-P86043

	Myosin Heavy Chain Smooth Muscle Antibody (YA5735) myosin-11; myosin heavy chain 11; myosin heavy chain, smooth muscle isoform; SMMHC;	IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Myosin Heavy Chain Smooth Muscle Antibody (YA5735) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Myosin Heavy Chain Smooth Muscle.

HY-P81875

	Myosin Heavy Chain Smooth Muscle Antibody (YA1620) AAT4; FAA4; MYH11; myosin 11; myosin heavy chain 11; myosin heavy chain smooth muscle isoform; myosin heavy polypeptide 11 smooth muscle; SMHC; SMMHC	WB, IHC-P	Human, Mouse
	Myosin Heavy Chain Smooth Muscle Antibody (YA1620) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myosin Heavy Chain Smooth Muscle.

HY-P85656

	Myosin Heavy Chain Antibody (YA5348)	ICC/IF	Human, Mouse, Rat, FruitFly, Nematode
	Myosin Heavy Chain Antibody (YA5348) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Myosin Heavy Chain.

HY-P83782

	*Fast Myosin* Skeletal Heavy chain Antibody(YA3479)** adult 1 antibody; MYH1 antibody; MYH1_HUMAN antibody; MyHC-2x antibody; MyHC-IIx/d antibody; myosin heavy chain 1 antibody; myosin heavy chain 2x antibody; myosin heavy chain antibody; myosin heavy chain IIx/d antibody; myosin-1 antibody; skeletal muscle antibody	IHC-P, IF-Tissue	Human, Mouse, Rat
	Fast Myosin Skeletal Heavy chain Antibody(YA3479) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fast Myosin Skeletal Heavy chain.

HY-P80234

	Myosin heavy chain Antibody (YA279) cardiac muscle alpha isoform antibody; MYH6 antibody; MYH6_HUMAN antibody; MYH7 antibody; MYHC antibody; MyHC-alpha antibody; MyHC-beta antibody; MYHCA antibody; MYHCB antibody; myosin heavy chain 6 antibody; myosin heavy chain antibody; myosin heavy chain cardiac muscle alpha isoform antibody; myosin heavy chain cardiac muscle beta isoform antibody; myosin-6 antibody	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	Myosin heavy chain Antibody (YA279) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myosin heavy chain.

HY-P83369

	MYH10 Antibody (YA3114) NMMHCB; NMMHC-IIB; myosin-10, myosin heavy chain 10, Non-muscle myosin heavy chain B, Non-muscle myosin heavy chain IIb, NMMHC-B, NMMHC II-b, NMMHC-IIB, MYH10	WB, IP	Human, Mouse
	MYH10 Antibody (YA3114) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH10.

HY-P83369A

	MYH10 Antibody (YA3114)(PBS only) NMMHCB; NMMHC-IIB; myosin-10, myosin heavy chain 10, Non-muscle myosin heavy chain B, Non-muscle myosin heavy chain IIb, NMMHC-B, NMMHC II-b, NMMHC-IIB, MYH10	WB, IP	Human, Mouse
	MYH10 Antibody (YA3114) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH10.

HY-P87094

	*Slow Skeletal Myosin* Heavy chain Antibody (YA6787)** Beta myosin heavy chain antibody; cardiac muscle beta isoform antibody; CMD1S antibody; CMH1 antibody; MPD1 antibody; MYH7 antibody; MYH7_HUMAN antibody; Myhc slow antibody; MyHC-beta antibody; MyHC-slow antibody; Beta myosin heavy chain antibody; cardiac muscle beta isoform antibody; CMD1S antibody; CMH1 antibody; MPD1 antibody; MYH7 antibody; MYH7_HUMAN antibody; Myhc slow antibody; MyHC-beta antibody; MyHC-slow antibody; MYHCB antibody; Myopathy, distal 1 antibody; myosin heavy chain (AA 1-96) antibody; myosin heavy chain 7 antibody; myosin heavy chain antibody; myosin heavy chain slow isoform antibody; myosin heavy chain, cardiac muscle beta isoform antibody; myosin, heavy chain 7, cardiac muscle, beta antibody; myosin, heavy polypeptide 7, cardiac muscle, beta antibody; myosin-7 antibody; Rhabdomyosarcoma antigen MU RMS 40.7A antibody; SPMD antibody; SPMM antibody;	WB, IHC-P, IF-Tissue, IHC-F	Human, Mouse, Rat
	Slow Skeletal Myosin Heavy chain Antibody (YA6787) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Slow Skeletal Myosin Heavy chain.

HY-P86969

	MYH2 Antibody (YA6662) adult 2 antibody; Fast 2a myosin heavy chain antibody; IBM3 antibody; Inclusion body myopathy 3, autosomal dominant antibody; MYH2 antibody; MYH2_HUMAN antibody; MYH2A antibody; MYHas8 antibody; MyHC IIa antibody; MyHC-2a antibody; adult 2 antibody; Fast 2a myosin heavy chain antibody; IBM3 antibody; Inclusion body myopathy 3, autosomal dominant antibody; MYH2 antibody; MYH2_HUMAN antibody; MYH2A antibody; MYHas8 antibody; MyHC IIa antibody; MyHC-2a antibody; MyHC-IIa antibody; MYHSA2 antibody; myosin heavy chain 2 antibody; myosin heavy chain 2a antibody; myosin heavy chain antibody; myosin heavy chain IIa antibody; myosin heavy chain skeletal muscle adult 2 antibody; myosin heavy polypeptide 2 skeletal muscle adult antibody; myosin-2 antibody; MYPOP antibody; skeletal muscle antibody; Type IIA myosin heavy chain antibody;	WB, IHC-P	Human, Mouse, Rat
	MYH2 Antibody (YA6662) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH2.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.