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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
noradrenaline uptake transporter
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "noradrenaline uptake transporter" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-B1704
CAS No.: 53179-07-0
Target:
Research Areas:
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .
2
2 Cited Publications
Cat. No.: HY-B1704A
CAS No.: 57754-86-6
Target:
Research Areas:
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .
Cat. No.: HY-125784A
CAS No.: 56287-63-9
Target:
Research Areas:
(R)-Viloxazine hydrochloride is the less active R-isomer of Viloxazine hydrochloride (HY-125784). (R)-Viloxazine hydrochloride can be used in the research of depression .
Cat. No.: HY-B1704R
CAS No.: 53179-07-0
Target:
Research Areas:
Nisoxetine (Standard) is the analytical standard of Nisoxetine. This product is intended for research and analytical applications. Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .
Cat. No.: HY-125784AS
CAS No.: 1246815-04-2
Synonyms: (R)-Viloxazin-d5 hydrochloride; (R)-Emovit-d5 hydrochloride
Research Areas:
(R)-Viloxazine-d5 hydrochloride ((R)-Viloxazin-d5 hydrochloride; (R)-Emovit-d5 hydrochloride) is the deuterated-labeled (R)-Viloxazine hydrochloride (HY-125784A). (R)-Viloxazine hydrochloride is the less active R-isomer of Viloxazine hydrochloride (HY-125784). (R)-Viloxazine hydrochloride can be used in the research of depression .
Cat. No.: HY-105521A
CAS No.: 94096-42-1
Synonyms: (S)-Nafenodone; LU-43706
Target:
Research Areas:
Dexnafenodone hydrochloride ((S)-Nafenodone; LU-43706) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone hydrochloride inhibits the fast inward Na + current and slow inward Ca 2+ current in cardiomyocytes. Dexnafenodone hydrochloride inhibits voltage-gated and receptor-activated Ca 2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca 2+ stores, suppresses agonist-stimulated Ca 2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone hydrochloride can be used in the research of depression .
Cat. No.: HY-124492
CAS No.: 21489-22-5
Target:
Research Areas:
Prindamine is a noradrenaline transporter inhibitor with very weak anticholinergic and serotonin (5-HT) uptake inhibiting effects. Prindamine blocks noradrenaline uptake, increasing synaptic availability of noradrenaline in the brain. Prindamine decreases rapid eye movement sleep (REMS) in cats. Prindamine initially increases the proportion of time spent in active wakefulness in cats .
Cat. No.: HY-183404
CAS No.: 72807-01-3
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Research Areas:
Wy 25093 is a selective serotonin (5-HT) uptake transporter inhibitor. Wy 25093 regulates the turnover and metabolism of central 5-HT, enhances postsynaptic 5-HT actions and 5-hydroxytryptophan-induced behavioral syndrome. Wy 25093 induces ipsilateral and contralateral circling behavior in rats, reduces the turnover rate of striatal dopamine, decreases the level of 5-hydroxyindole-3-acetic acid in the brain, and long-term administration reduces brain 5-HT levels. Wy 25093 can be used in research related to depression .
Cat. No.: HY-105521
CAS No.: 92629-87-3
Synonyms: (S)-Nafenodone free base; LU-43706 free base
Target:
Research Areas:
Dexnafenodone ((S)-Nafenodone free base; LU-43706 free base) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone inhibits the fast inward Na + current and slow inward Ca 2+ current in cardiomyocytes. Dexnafenodone inhibits voltage-gated and receptor-activated Ca 2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca 2+ stores, suppresses agonist-stimulated Ca 2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone can be used in the research of depression .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
